Author(s): Emy Koestanti Sabdoningrum, Sri Hidanah, Arif N. M. Ansori, Amaq Fadholly

Email(s): emykoestanti@yahoo.co.id

DOI: 10.5958/0974-360X.2020.00404.7   

Address: Emy Koestanti Sabdoningrum1, Sri Hidanah1, Arif N. M. Ansori2, Amaq Fadholly2
1Department of Animal Husbandry, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, 60115, East Java, Indonesia.
2Doctoral Program in Veterinary Science, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, 60115, East Java, Indonesia.
*Corresponding Author

Published In:   Volume - 13,      Issue - 5,     Year - 2020


ABSTRACT:
The purpose of this study was to determine the Phyllanthus niruri L. extract (PNE) as an immunomodulator and antioxidant in laying hens infected by Escherichia coli. This study used completely randomized design (CRD) with 20 chickens divided into six groups consisting of one negative control group given Na-CMC (P0-), positive control group given E. coli (P0+), and three test groups given the PNE 10% (P1), 20% (P2), and 30% (P3). Each test group was given a sample suspension orally by giving once a day for six consecutive days. At the age of 21 weeks E. coli was infected with concentration of 106 CFU/mL/body weight. After a week of the E. coli infection, PNE was given with various dosage for 4 weeks. We revealed the data of leukocytes, lymphocytes, SOD and MDA. The data were analyzed by analysis of variance and Duncan test. Interestingly, we showed that PNE at a dose of 10% can increase immune system and antioxidant activity. In sum, we conclude that PNE can increase immune system and antioxidant activity in laying hens infected with E. coli.


Cite this article:
Emy Koestanti Sabdoningrum, Sri Hidanah, Arif N. M. Ansori, Amaq Fadholly. Immunomodulatory and Antioxidant Activities of Phyllanthus niruri L. Extract against the Laying Hens Infected by Escherichia coli. Research J. Pharm. and Tech 2020; 13(5): 2246-2250. doi: 10.5958/0974-360X.2020.00404.7

Cite(Electronic):
Emy Koestanti Sabdoningrum, Sri Hidanah, Arif N. M. Ansori, Amaq Fadholly. Immunomodulatory and Antioxidant Activities of Phyllanthus niruri L. Extract against the Laying Hens Infected by Escherichia coli. Research J. Pharm. and Tech 2020; 13(5): 2246-2250. doi: 10.5958/0974-360X.2020.00404.7   Available on: https://rjptonline.org/AbstractView.aspx?PID=2020-13-5-34


REFERENCES:
1.    Wahjuni RS, Sabdoningrum EK, Sri H. Effectiveness Meniran (Phyllanthus niruri Linn) as Immunomodulation on Lymphocyte of Broiler Infected with Enterotoxin Escherichia coli Resistant Antibiotics. Journal of Vocational Program University of Indonesia. 2017; 5(2): 17-20.
2.    Ansori ANM, Susilo RJK, Hayaza S, Winarni D, Husen SA. Renoprotection by Garcinia mangostana L. Pericarp Extract in Streptozotocin-Induced Diabetic Mice. Iraqi Journal of Veterinary Sciences. 2019; 33(1): 13-19.
3.    Husen SA, Wahyuningsih SPA, Ansori ANM, Hayaza S, Susilo RJK, Darmanto W, Winarni D. The Effect of Okra (Abelmoschus esculentus Moench) Pods Extract on Malondialdehyde and Cholesterol Level in STZ-Induced Diabetic Mice. 2019; Ecology, Environment and Conservation. 25(4): S50-S56.
4.    Husen SA, Winarni D, Salamun, Ansori ANM, Susilo RJK, Hayaza S. Hepatoprotective Effect of Gamma-Mangostin for Amelioration of Impaired Liver Structure and Function in Streptozotocin-Induced Diabetic Mice. IOP Conference Series: Earth and Environmental Science. 2019; 217(1): 012031.
5.    Fadholly A, Ansori ANM, Jayanti S, Proboningrat A, Kusala MKJ, Putri N, Rantam FA, Sudjarwo SA. Cytotoxic Effect of Allium cepa L. Extract on Human Colon Cancer (WiDr) Cells: In Vitro Study. Research Journal of Pharmacy and Technology 2019; 12(7): 3483-3486.
6.    Elfahmi, Batterman S, Koulman A, Hackl T, Bos R, Kayser O, Woerdenbag HJ, Quax J. Lignans from Cell Suspension Cultures of Phyllanthus niruri, an Indonesian Medicinal Plant. Journal of Natural Products. 2006; 69(1): 55-58.
7.    Bagalkotkar G, Sagineedu SR, Saad MS, Stanslas J. Phytochemicals from Phyllanthus niruri Linn. and Their Pharmacological Properties: A Review. Journal of Pharmacy and Pharmacology. 2006; 58(12): 1559-1570.
8.    Putri DU, Rintiswati N, Soesatyo MH, Haryana SM. Immune Modulation Properties of Herbal Plant Leaves: Phyllanthus niruri Aqueous Extract on Immune Cells of Tuberculosis Patient - in vitro Study. Natural Product Research. 2018; 32(4): 463-467.
9.    Sarin B, Verma N, Martín JP, Mohanty A. An Overview of Important Ethnomedicinal Herbs of Phyllanthus Species: Present Status and Future Prospects. Scientific World Journal. 2014; 2014: 839172.
10.    Nisar MF, He J, Ahmed A, Yang Y, Li M, Wan C. Chemical Components and Biological Activities of the Genus Phyllanthus: A Review of the Recent Literature. Molecules. 2018; 23(10): 2567.
11.    Moura DJ, Richter MF, Boeira JM, Pêgas Henriques JA, Saffi J. Antioxidant Properties of Beta-Carboline Alkaloids are Related to Their Antimutagenic and Antigenotoxic Activities. Mutagenesis. 2007; 22(4): 293-302.
12.    Oboh G, Ademosun AO. Characterization of the Antioxidant Properties of Phenolic Extracts from Some Citrus Peels. Journal of Food Science and Technology. 2012; 49(6): 729-736.
13.    Kim MY, Seguin P, Ahn JK, Kim JJ, Chun SC, Kim EH, Seo SH, Kang EY, Kim SL, Park YJ, Ro HM, Chung IM. Phenolic Compound Concentration and Antioxidant Activities of Edible and Medicinal Mushrooms from Korea. Journal of Agricultural and Food Chemistry. 2008; 56(16): 7265-7270.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags


Not Available