Green protocol for the synthesis of series of substituted dihydro-pyrimidine-carboxylate using solid support has been designed with the assistance of microwave irradiation technique. Purpose of green synthesis via microwave irradiation is to proceed with all the synthetic procedures which are eco friendly and economic in terms of better yields, shorter reaction time as compared to conventional methods. The success of reaction was observed by physical methods like melting point, TLC, molecular weight and formula. On completion of reaction, reaction products were characterized in details using physical and chemical and spectral techniques such as melting point, IR, NMR, FTIR, Mass spectra etc. Not only is direct microwave irradiation technique able to reduce reaction times from hours to minutes, but it is also known to reduce side reactions, increase yields and improve reproducibility. The obtained products were of moderate to good yields.
Cite this article:
Bindiya Sharma, Anamika Jain, Navneeta Upadhyay. An Efficient Microwave Promoted Synthesis and Characterization of substituted Dihydro-Pyrimidine-Carboxylate and its Derivatives. Research J. Pharm. and Tech 2018; 11(12): 5541-5544. doi: 10.5958/0974-360X.2018.01008.9