Author(s): Sarma Shreya Balaram, Akula Ramesh and Jagadish P.C.

Email(s): Email ID Not Available

DOI: Not Available

Address: Sarma Shreya Balaram, Akula Ramesh and Jagadish P.C.* Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, 576104, Karnataka, India. *Corresponding Author

Published In:   Volume - 7,      Issue - 10,     Year - 2014


ABSTRACT:
Aripiprazole is an atypical neuroleptic drug used to manage conditions like schizophrenia and bipolar disorder. The aim of current work is to compare UV spectrophotometric and derivative techniques of aripiprazole to establish simple, sensitive method. In different spectrophotometric orders of aripiprazole, zero order has shown maximum absorbance at 217nm. Experimental wavelengths in other derivative orders were selected considering maximum absorbance. Wavelength difference and smoothing factor values were optimized to give improved spectral resolution and sensitivity. The method was linear and obeyed Beer’s law in the range of 1.0-6.0 µg/mL. Linearity, limit of detection (LOD), limit of quantitation (LOQ) and accuracy were evaluated for each order as per ICH Guidelines. First order has shown highest correlation coefficient with lower values of LOD and LOQ whereas other derivative orders have shown higher values. So, first order derivative spectroscopy was identified as the best for the estimation of aripiprazole in bulk drug and formulation.


Cite this article:
Sarma Shreya Balaram, Akula Ramesh and Jagadish P.C. Estimation of Aripiprazole in Bulk Drug and Formulation by UV-Derivative Spectroscopy. Research J. Pharm. and Tech. 7(10): Oct. 2014 Page 1113-1117.


Recomonded Articles:

Author(s): Hemlata M. Nimje, Rajesh J. Oswal, Sandip S. Kshirsagar, Manoj Chavan

DOI: Not Available         Access: Open Access Read More

Author(s): Jayesh M Jain, Dinesh M Sakarkar, Shajahan Abdul, Mangesh E Bhad, Anil V Chandewar and Sunil B Jaiswal

DOI: Not Available         Access: Closed Access Read More

Author(s): Rajendra Jangde, S. J. Daharwal

DOI: Not Available         Access: Open Access Read More

Author(s): Sandra Sajen, Jephin Varughese Jose, Sandeep Bukke, Chaithanya Sudha M, Saladi S.V. Subbarao, V.R. Mandla

DOI: 10.5958/0974-360X.2017.00286.4         Access: Open Access Read More

Author(s): Pratik N. Shah, Bhavini N. Patel, Chaganbhai N. Patel

DOI: Not Available         Access: Open Access Read More

Author(s): Kumaraswamy G., J.M. Rajendrakumar, J.V.L.N. Sheshagirirao, U. Ashok Kumar, M. Arunadevi

DOI: Not Available         Access: Open Access Read More

Author(s): Bulusu Ravi Teja, Bhupathi Raju Kishan Varma, Chandaka Prasanna Kumar, Mukthinuthalapati Mathrusri Annapurna

DOI: 10.5958/0974-360X.2017.00206.2         Access: Open Access Read More

Author(s): B Srivastava, Uttam Singh Baghel, Pradeep Swarnkar and Shuchi Dave

DOI: Not Available         Access: Open Access Read More

Author(s): Akelesh T., Sam Johnson, Udaya Chander J., Subhojit Samantha, Venkatanarayanan R.

DOI: 10.5958/0974-360X.2015.00268.1         Access: Open Access Read More

Author(s): Garima Singh, Amrita Mishra, Anurag Verma, Arun K. Mishra

DOI: Not Available         Access: Open Access Read More

Author(s): Anuruddha R. Chabukswar, Shital D. Tambe, Vishnu P. Choudhari, Shailesh N. Sharma, Mayuri N. Mohokar, Subhash Chate

DOI: Not Available         Access: Open Access Read More

Author(s): Lakshmi Aswini G., Dhachinamoorthi D., Seshagiri Rao J.V.L.N., Prasada Rao C.H., Surekha M.L

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags