Author(s): Rajendra Jangde, Deependra Singh

Email(s): rjangdepy@gmail.com

DOI: Not Available

Address: Rajendra Jangde* and Deependra Singh
University Institute of Pharmacy, Pt. Ravishankar Shukla University, Raipur-492010 C.G. India
*Corresponding Author

Published In:   Volume - 7,      Issue - 10,     Year - 2014


ABSTRACT:
The aim of study was for the development of any novel formulation, assessment of drug-excipients compatibility using different techniques such as thermal and isothermal stress testing were used to assess the compatibility of drug with excipients., represents an important phase in preformulation stage. Differential scanning calorimetry (DSC) and Fourier transformation infrared spectroscopy (FTIR) and X-ray diffraction study (XRD) were the common methods for the study of compatibility. The potential physical and chemical interactions between the drug and excipients can affect the chemical nature, stability, bioavailability of drugs and subsequently, affects their therapeutic efficacy and safety. . In the present study drug excipients compatibility study of quercetin was conducted with different controlled release excipients. The drug and excipients mixtures were stored at 50°C for 4 weeks. The samples were then characterized using DSC, FTIR and UV spectrophotometric methods. The results show that quercetin was compatible with the all the excipients used in the study. The excipients used in the present study were definitely incorporated in the extended release quercetin formulation. On the basis of the results obtained from DSC, FTIR and XRD studies, all the excipients used were found to be compatible with the quercetin and can be used for the development of novel formulation.


Cite this article:
Rajendra Jangde, Deependra Singh. Compatibility Studies of Quercetin with Pharmaceutical Excipients Used in the Development of Novel Formulation. Research J. Pharm. and Tech. 7(10): Oct. 2014 Page 1101-1105.


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