Author(s): Chapalamadugu Ugandhar

Email(s): ugandhar.ch1@gmail.com

DOI: Not Available

Address: Chapalamadugu Ugandhar*
Al-Ameen College of Pharmacy, Bangalore, Karnataka.
*Corresponding Author

Published In:   Volume - 5,      Issue - 6,     Year - 2012


ABSTRACT:
A simple technique of solid dispersion was used in the present investigation. Solid dispersions of mesalazine was prepared by using different carriers such as HPMC K15M and peg 6000. Various solid dispersions were prepared as described in the methodology. Solid state and drug polymer interactions were carried out by UV studies, these studies revealed that drug and polymer were compatible. The dissolution was carried out by USP, basket method. From the results, formulation PEG-1:2 (drug:polymer-1:2) released 87.7% of drug within 8 hours . All the other formulations released were formulated such that they showed enhanced dissolution rate with PEG and HPMC in different ratios. In-vitro release indicated that the solid dispersion containing PEG-1:2 had better dissolution profile when compared with others.


Cite this article:
Chapalamadugu Ugandhar. Formulation and Evaluation of Mesalazine Solid Dispersion. Research J. Pharm. and Tech. 5(6): June 2012; Page 809-812.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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