Research Journal of Pharmacy and Technology

ISSN

0974-360X (Online)
0974-3618 (Print)


Submit Article

Development and Validation of Spctrophotometric Method for Simultaneous Estimation of Amlodipine Besylate and Indapamide in Tablet Dosage Form

Author(s): Raj Manish C., Chaudhari Bharat G

Email(s): manish21288@gmail.com

DOI: Not Available

Address: Raj Manish C. * and Chaudhari Bharat G.
Department of Quality Assurance, Shree S. K. Patel Collage of Pharmaceutical Education and Research, Ganpat University, Ganpat Vidyanagar – 384 012, Mehsana, Gujarat, India.
*Corresponding Author

Published In:   Volume - 5,      Issue - 6,     Year - 2012

 View HTML        View PDF

ABSTRACT:
The present manuscript describes simple, sensitive, rapid, accurate, precise and economic dual wavelength spectrophotometric method for simultaneous determination of amlodipine besylate and indapamide in combined tablet dosage form. The utility of dual wavelength data processing program is its ability to calculate unknown concentration of components of interest in a mixture containing an interfering component. The principle for dual wavelength method is “the absorbance difference between two points on the mixture spectra is directly proportional to the concentration of the component of interest”. The wavelengths selected for determination of amlodipine besylate were 255 nm and 360 nm, whereas the wavelengths selected for determination of indapamide were 241.6 nm and 217.6 nm. The two drugs follow Beer-Lambert’s law over the concentration range of 10-60 µg/ml for AMLO and 3-18 µg/ml for INDA. The method was successfully applied to pharmaceutical dosage form because no interference from the tablet excipients was found. The results of analysis have been validated statistically and by recovery studies.


Keywords:

Cite this article:
Raj Manish C., Chaudhari Bharat G. Development and Validation of Spctrophotometric Method for Simultaneous Estimation of Amlodipine Besylate and Indapamide in Tablet Dosage Form. Research J. Pharm. and Tech. 5(6): June 2012; Page 795-799.


Recomonded Articles:

Analytical method development and validation of ambroxol hydrochloride by UV spectroscopy and forced degradation study and detection of stability.

Author(s): M. Sumithra, P. Yuvanesh, Anamika Mistry

DOI: 10.5958/0974-360X.2016.00152.9         Access: Open Access Read More

RP-HPLC Method for Simultaneous Estimation of Albendazole and Niclosamide in Oral Suspension for Veterinary Use

Author(s): Murugan S, Upendra Janardhan CH, Niranjan Babu M

DOI: DOI: 10.5958/0974-360X.2016.00006.8         Access: Open Access Read More

Adhesive Polymers in Fabrication of Transdermal Drug delivery

Author(s): Niharika, Navneet Verma

DOI: 10.5958/0974-360X.2016.00182.7         Access: Open Access Read More

Development of a Validated Reverse Phase Liquid Chromatographic Assay-Method for determination of Tofacitinib in pure form and in Physical Admixtures

Author(s): A. S. K. Sankar, B. Datchayani, N. Balakumaran, Mohammed Rilwan, R. Subaranjani

DOI: 10.5958/0974-360X.2017.00047.6         Access: Open Access Read More

Review on: New approaches in self micro-emulsifying drug delivery system

Author(s): Ravindranath S. Misal, Vishawas R. Potphode, Vijay R. Mahajan

DOI: 10.5958/0974-360X.2017.00218.9         Access: Open Access Read More

A comparative, Bioequivalence study to evaluate the safety and pharmacokinetic profile of single dose Ivabradine 7.5mg Tablets in healthy, adult, human subjects under fasting condition.

Author(s): Amol K Choulwar, Ashish A. Mungantiwar, Meena Chintamaneni

DOI: Not Available         Access: Open Access Read More

Taxonomical, Phytochemical and Pharmacological Reviews of Musa sapientum var. Paradisiaca.

Author(s): U.S Mahadeva Rao, Khamsah Suryati Mohd, Abdurrazaq Muhammad, Bashir Ado Ahmad, Mohaslinda Mohamad, Rosmawati Mat Ali

DOI: Not Available         Access: Open Access Read More

Prescribing Pattern of Drugs Used For Respiratory Disease in Pediatric Patients at Private Hospital

Author(s): P. Geetha, M. Kousalya, S. Geetha Lakshmi, R. Gopi.

DOI: 10.5958/0974-360X.2016.00046.9         Access: Open Access Read More

Analytical Method Development and Validation for Simultaneous Estimation of Montelukast and Ebastine by HPLC

Author(s): Baokar Shrikrishna, Ranpise Nisharani

DOI: 10.5958/0974-360X.2015.00001.3         Access: Open Access Read More

Method development and validation of Bronopol (Preservative) and its Stability Indicating Study by UV Spectrophotometry

Author(s): Pankaj Kapupara, Dhara Parekh, Ketan Shah

DOI: 10.5958/0974-360X.2016.00175.X         Access: Open Access Read More

Weight and Content Uniformity of Warfarin Sodium Half Tablets

Author(s): Mostafa Isbera, Ayat Abbood, Wehad Ibrahim

DOI: 10.5958/0974-360X.2016.00039.1         Access: Open Access Read More

Formulation and Evaluation of Mucoadhesive Buccal Tablets of Curcumin and its Bioavailability Study

Author(s): Deepak Karki, Gururaj S. Kulkarni, Shivakumar Swamy, Sheeba FR

DOI: 10.5958/0974-360X.2017.00750.8         Access: Open Access Read More

An exhaustive review based on the formulation and evaluation methods behind the development of transdermal drug delivery systems

Author(s): Archana Kushwaha, Jayanti Jaiswal, Priya Singh, Neha Rathore, Jai Prakash Dhruw, Ishu Sahu, Chhaya Singh, Krinsha Kumar Sahu, Mukta Agrawal, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0974-360X.2017.00270.0         Access: Open Access Read More

Comparative Evaluation of Quality Control Parameters of Marketed Antidiabetic Tablet

Author(s): S.M. Charjan, S.K. Bais, R.R. Shiradkar, R.L. Bakal, V.M. Durge, A.V. Chandewar

DOI: Not Available         Access: Open Access Read More

Analytical and Bioanalytical Method for Quantification of Pure Azilsartan, Not its Salts by RP-HPLC

Author(s): Mukta D. Naykode, Durgacharan A. Bhagwat, Swapnil D. Jadhav, Harinath N. More

DOI: 10.5958/0974-360X.2017.00133.0         Access: Open Access Read More

Formulation and Evaluation of Mouth Dissolving Tablets of Domperidone

Author(s): Avinash Bhagwat, Suhas M Kakade, Chirag V Naval, Mukesh Tilker, Ravindra M Walture, Sagar A Adichwal and Atul P Chaudhari

DOI: Not Available         Access: Open Access Read More

Formulation and Evaluation of Extended Release Matrix Formulation of Metoprolol Succinate

Author(s): Rekha Kallam, Padma Sree K, Srinivas Arutla, MA Bari

DOI: Not Available         Access: Open Access Read More

A Mini-Review of Spectrophotometric and Chromatographic Analysis and Bioanalysis of Selected Recently Approved Anti-Diabetic Combinations

Author(s): Maha F. Abdel-Ghany, Miriam F. Ayad, Mariam M. Tadros

DOI: 10.5958/0974-360X.2017.00563.7         Access: Open Access Read More

Formulation and Evaluation of Sustained Release Floating Matrix Tablets of Labetalol Hydrochloride.

Author(s): Ravi K. Barde, Minal R. Narkhede, V.R. Gudsoorkar, Rahul K. Amrutkar, Prashant S. Walke

DOI: Not Available         Access: Open Access Read More

Determination of Calcipotriene in Calcipotriene Cream 0.05% w/w by RP-HPLC Method Development and Validation

Author(s): Mayanka Singh, Manoj Charde, Rajesh Shukla, Rita M. Charde

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus

SCImago Journal & Country Rank

Quick Links

Latest Issues

Popular Articles


Recent Articles



Effect of Emblica officinalis (Amla) on Monosodium Glutamate (MSG) Induced Uterine Fibroids in Wistar Rats
Regulatory requirements for Post approval changes in Japan, Canada and Malaysia
Curcumin Potentiates Therapeutic Efficacy of Metformin: A Preclinical Study in STZ-NA Induced Hyperglycemia in Wistar Rats
Synthesis and Antibacterial activity of some newer Benzimidazole derivatives
The Correction Methods of the Intestinal Microflora in Chronic Colonic Stasis by Siphon Enema and Probiotics as a Means of the Hirschsprung-associated Enterocolitis Prevention
Stability Indicating HPTLC Determination of Tadalafil Hydrochloride in Bulk Drug and Pharmaceutical Formulations
Biochemical Evaluation of Antidiabetic properties of Strychnos potatorum Seeds extract studied in High Fat Diet Fed- Low dose Streptozotocin induced experimental type 2 diabetes in Rats
In Vitro Antioxidant and Antibacterial Screening of flowers Extract from Cassia auriculata Linn.
Preparation and Evaluation of Mouth Dissolving Tablets of Loratadine by Direct Compression Method
Phytochemical assessment and Bioactivity of alcoholic extract seed of Louranthus europpaeus
Design, Development and Evaluation of Solid Form of Liquid Self-Nanoemulsifying Formulation for improving the Oral Bioavailability of Itraconazole
Optimization and Characterization of Exopolysaccharide from Marine Soil Bacteria
Development and Validation of an RP-HPLC Analytical Method for Determination of Lisinopril in Full and Split Tablets
Preparation of Silver Nanoparticles from Bael (Aegle marmelos) Leaves Extract and their Doping with Multiwalled Carbon Nanotubes for Antibacterial Utility
An effective multicomponent synthesis of 2,6-dihydro-2,6-diimino-4,8-bis (phenylamino) pyrimido [2,1-b] [1,3] thiazine-3,7-dicarbonitrile
Synthesis, Characterization and Anti-oxidant Activity of Novel Phenylhydrazine derivatives containing carbonyl group on β- carbon
Pharmacognostical Evaluation and HPTLC Analysis of Two Medicinally important Secondary Metabolites in Bauhinia variegata Leaves from Gorakhpur District in Summer Season
Formulation, Characterization of Anticancer Nanoemulsion containing Trigonella foenum-graecum L. Seed oil
Endoscopic Retrograde Cholangiopancreatography in Central Iraq: A Retrospective Single- Center Study
Biosynthesis of Gold Nanoparticles using Leaf Extract of Desmodium gangeticum and their Antioxidant Activity

Tags


About Journal

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal, devoted to pharmaceutical sciences. The aim of RJPT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical chemistry including medicinal and analytical chemistry; Pharmacognosy including herbal products standardization and Phytochemistry; Pharmacology: Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
Read More  

Visitors

Today: 1991
Yesterday: 10367
Total: 1597456