Author(s): Arpit H. Patel, Sachin A. Pishawikar, Harinath N More

Email(s): arpitpatel1987@yahoo.com

DOI: Not Available

Address: Arpit H. Patel1*, Sachin A. Pishawikar2, Dr. Harinath N More3.
Department of Quality Assurance, Bharati Vidyapeeth’s College of Pharmacy, Kolhapur, 416 013, Maharashtra
*Corresponding Author

Published In:   Volume - 5,      Issue - 6,     Year - 2012


ABSTRACT:
The present communication reports the degradation behavior of Lansoprazole (LNS) under various stress conditions through a simple, accurate, precise, reproducible and economical UV-spectrophotometric method for LNS estimation from bulk drug and capsule dosage form simultaneously with its degradation products. The degradation behavior of LNS was investigated through dry heat treatment, UV-exposure, acid hydrolysis, alkali hydrolysis and oxidation. It was found that the compound shows lack of stability under oxidative conditions which when compared to other stress conditions, found moderately stable. The UV spectral characteristics of the drug and degraded products were quite different and zero order UV spectrophotometric method was used to study the extent of degradation. A mixture of Acetonitrile:Water(70:30) was employed as a solvent. Lansoprazole showed maximum absorbance at 284nm. The calibration curve obeys the Beer’s Law in the concentration range 2-40 µg/ml with correlation coefficient value 0.998. The developed reliable zero-order method was validated for as per ICH guidelines. Statistical analysis proved that the method was simple and rapid for the estimation of Lansoprazole and can be used for routine analysis of Lansoprazole in laboratories and industry


Cite this article:
Arpit H. Patel, Sachin A. Pishawikar, Harinath N More. Comparative Study between Stress Degradation Analysis on Lansoprazole and its Estimation by Zero-Order UV-Spectrophotometric Method. Research J. Pharm. and Tech. 5(6): June 2012; Page 822-828.


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RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

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