Author(s):
Zahraa Ali Al-Aradi, Muayad Sraibet Abood, Mufeda Ali Jwad
Email(s):
zahraa.1984.aradi@gmail.com , dr.muayad@st.nahrainuniv.edu.iq , dr.mufedaali@st.nahrainuniv.edu.iq
DOI:
10.52711/0974-360X.2026.00564 
Address:
Zahraa Ali Al-Aradi1*, Muayad Sraibet Abood2, Mufeda Ali Jwad3
1Department of Physiology, High Institute for Infertility Diagnosis and Assisted Reproductive Technologies, Al- Nahrain University, Baghdad, Iraq.
2Department of Applied Embryology, High Institute for Infertility Diagnosis and Assisted Reproductive Technologies, Al- Nahrain University, Baghdad/Iraq.
3Department of Physiology, High Institute for Infertility Diagnosis and Assisted Reproductive Technologies/Al- Nahrain University, Baghdad, Iraq.
*Corresponding Author
Published In:
Volume - 19,
Issue - 9,
Year - 2026
ABSTRACT:
Background: Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder that adversely affects reproductive outcomes in women undergoing ICSI. Premature LH surges during controlled ovarian stimulation (COS) can compromise oocyte yield, particularly in high-responders. Objective: To compare follicular response and hormonal profiles in PCOS women undergoing ICSI following suppression with either Medroxyprogesterone Acetate (MPA) or GnRH antagonist protocols. Patients and Methods: This study enrolled 108 infertile women with PCOS undergoing ICSI at the Al-Nahrain University Center between December 2023 and May 2025. 59 participants received GnRH antagonist protocols, while 49 were treated with MPA. Parameters assessed included LH levels, estradiol, oocyte maturity, and ovarian sensitivity index. Results: LH levels on day 2, day 6, and trigger day showed no significant differences between groups (p=0.62, 0.26, 0.14). The MPA group had a slightly higher, but non-significant, number of retrieved oocytes (p=0.83). Gonadotropin dose, duration of stimulation, ovarian responsiveness, and mature oocyte (MII) yield were comparable between groups (p>0.05). Oocyte maturity did not differ significantly. Conclusion: Medroxyprogesterone acetate is an effective, safe, and cost-efficient alternative to GnRH antagonists for preventing premature LH surges in PCOS women undergoing ICSI, without compromising ovarian response, oocyte maturity, or stimulation outcomes.
Cite this article:
Zahraa Ali Al-Aradi, Muayad Sraibet Abood, Mufeda Ali Jwad. Hormonal Profiles and Follicular Responses in PCOS women during ICSI Cycles: A Study Comparing Medroxyprogesterone Acetate and GnRH Antagonist Suppression Strategies. Research Journal Pharmacy and Technology. 2026;19(9):4021-6. doi: 10.52711/0974-360X.2026.00564
Cite(Electronic):
Zahraa Ali Al-Aradi, Muayad Sraibet Abood, Mufeda Ali Jwad. Hormonal Profiles and Follicular Responses in PCOS women during ICSI Cycles: A Study Comparing Medroxyprogesterone Acetate and GnRH Antagonist Suppression Strategies. Research Journal Pharmacy and Technology. 2026;19(9):4021-6. doi: 10.52711/0974-360X.2026.00564 Available on: https://rjptonline.org/AbstractView.aspx?PID=2026-19-9-10
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