Author(s):
Shridhar Jadhav, Amit Rathod, A. R. Rajan
Email(s):
drshrijadhav@gmail.com , amitrathod045@gmail.com , aramanrajan@gmail.com
DOI:
10.52711/0974-360X.2026.00519 
Address:
Shridhar Jadhav1*, Amit Rathod2, A. R. Rajan3
1Department of Paediatrics, Symbiosis Medical College for Women and Symbiosis University Hospital and Research Centre, Symbiosis International (Deemed University) Pune, India.
2Department of Paediatrics, Symbiosis Medical College for Women and Symbiosis University Hospital and Research Centre, Symbiosis International (Deemed University) Pune, India.
3Department of Paediatrics, Symbiosis Medical College for Women and Symbiosis University Hospital and Research Centre, Symbiosis International (Deemed University) Pune, India.
*Corresponding Author
Published In:
Volume - 19,
Issue - 8,
Year - 2026
ABSTRACT:
Childhood hypothyroidism is one of the commonest treatable cause of mental retardation. Serum thyroid stimulating hormone (TSH) levels are routinely estimated as a screening test to diagnose thyroid dysfunction. In premature infants, owing to immature hypothalamic-pituitary axis the diagnosis of hypothyroidism requires understanding of thyroid physiology and neonatal milieu intérieur. We intended to identify trends of TSH levels of preterm neonates above 24 weeks of gestational age at birth and term and found out transient hypothyroidism in a known phenomenon in preterm newborns which is more common than term newborns and a repeat TSH screening at term could help us confirm the diagnosis.
Cite this article:
Shridhar Jadhav, Amit Rathod, A. R. Rajan. Trends of TSH Levels of Preterm Neonates above 24 weeks of Gestational age at Birth and Term. Research Journal of Pharmacy and Technology. 2026;19(8):3679-3. doi: 10.52711/0974-360X.2026.00519
Cite(Electronic):
Shridhar Jadhav, Amit Rathod, A. R. Rajan. Trends of TSH Levels of Preterm Neonates above 24 weeks of Gestational age at Birth and Term. Research Journal of Pharmacy and Technology. 2026;19(8):3679-3. doi: 10.52711/0974-360X.2026.00519 Available on: https://rjptonline.org/AbstractView.aspx?PID=2026-19-8-36
REFERENCES:
1. Parks JS, Lin M, Grosse SD, Hinton CF, Drummond-Borg M, Borgfeld L, Sullivan KM. The impact of transient hypothyroidism on the increasing rate of congenital hypothyroidism in the United States. Pediatrics. 2010 May 1; 125[Supplement 2]: S54-63.
2. Bijarnia S, Wilcken B, Wiley VC. Newborn screening for congenital hypothyroidism in very-low-birth-weight babies: the need for a second test. Journal of Inherited Metabolic Disease. 2011 Jun 1; 34[3]: 827-33.
3. Kwon C, Farrell PM. The magnitude and challenge of false-positive newborn screening test results. Archives of Pediatrics and Adolescent Medicine. 2000 Jul 1;154[7]:714-8.
4. O'Leary PC, Feddema PH, Michelangeli VP, Leedman PJ, Chew GT, Knuiman M, Kaye J, Walsh JP. Investigations of thyroid hormones and antibodies based on a community health survey: the Busselton thyroid study. Clinical Endocrinology. 2006 Jan; 64[1]: 97-104.
5. Pass KA, Neto EC. Update: newborn screening for endocrinopathies. Endocrinology and Metabolism Clinics. 2009 Dec 1;38[4]:827-37.
6. Stathatos N. Thyroid Physiology. Medical Clinics. 2012 Mar 1; 96[2]: 165-73.
7. Brix TH, Kyvik KO, Hegedüs L. A population-based study of chronic autoimmune hypothyroidism in Danish twins. The Journal of Clinical Endocrinology and Metabolism. 2000 Feb 1;85[2]:536-9.
8. Panicker V, Wilson SG, Walsh JP, Richards JB, Brown SJ, Beilby JP, Bremner AP, Surdulescu GL, Qweitin E, Gillham-Nasenya I, Soranzo N. A locus on chromosome 1p36 is associated with thyrotropin and thyroid function as identified by genome-wide association study. The American Journal of Human Genetics. 2010 Sep 10; 87[3]: 430-5.
9. Dayan CM, Panicker V. Novel insights into thyroid hormones from the study of common genetic variation. Nature Reviews Endocrinology. 2009 Apr; 5[4]: 211.
10. Panicker V. Genetics of thyroid function and disease. The Clinical Biochemist Reviews. 2011 Nov;32[4]:165.
11. De Felice M, Di Lauro R. Minireview: intrinsic and extrinsic factors in thyroid gland development: an update. Endocrinology. 2011 Jun 21; 152[8]: 2948-56.
12. Kratzsch J, Pulzer F. Thyroid gland development and defects. Best Practice and Research Clinical Endocrinology and Metabolism. 2008 Feb 1; 22[1]: 57-75.
13. Fagman H, Nilsson M. Morphogenetics of early thyroid development. Journal of Molecular Endocrinology. 2011 Feb; 46[1]: R33-42.
14. Nilsson M, Fagman H. Development of the thyroid gland. Development. 2017 Jun 15; 144[12]: 2123-40.
15. Targovnik HM, Esperante SA, Rivolta CM. Genetics and phenomics of hypothyroidism and goiter due to thyroglobulin mutations. Molecular and Cellular Endocrinology. 2010 Jun 30; 322[1-2]: 44-55.