Author(s):
Supriya Shirke, Kishor Burade
Email(s):
shirkesupriya22@gmail.com , k_burade@rediffmail.com
DOI:
10.52711/0974-360X.2026.00485 
Address:
Supriya Shirke1*, Kishor Burade2
1Department of Pharmaceutics, Government College of Pharmacy, Karad, Maharashtra, India 415110.
2Department of Pharmacognosy, Government College of Pharmacy, Karad, Maharashtra, India 415110.
*Corresponding Author
Published In:
Volume - 19,
Issue - 8,
Year - 2026
ABSTRACT:
Background: A deficiency in the solubility of the active pharmaceutical ingredient (API) prevents products from reaching their full potential and therapeutic range in finished pharmaceuticals. Thus, solubility behaviour and dissolution rate of poorly soluble drugs presents impediments in pharmaceutical formulation and developments. Deficient solubility as well as low dissolution of API in GI fluids after oral administration often results in poor bioavailability. Solid dispersion multifaceted approach leverages to ameliorate the solubility of these entities. Objectives: The current investigation aims at formulating and evaluating solid dispersions of mesalamine, (Model drug; BCS IV entity) to boost solubility and dissolution profile. Mesalamine (5 amino salicylic acid) mitigates inflammatory bowel diseases such as ulcerative colitis and Chron’s disease. Methods: Mesalamine solid dispersions were prepared by fusion and solvent evaporation strategy with different polymers like kollicoat-IR, PVP K-30, PEG-6000 in different ratios. Solid dispersions were assessed for percentage yield, drug content, solubility, in-vitro dissolution. Results: It was confirmed that mesalamine was successfully converted into an amorphous state via polymers employed in solid dispersion. Developed mesalamine solid dispersion entailing kollicoat-IR, PVPK-30, Polyethylene glycol 6000 (PEG-6000) demonstrate amelioration in solubility in addition to dissolution rate by three folds than pure drug. Conclusion: The current investigation infers that solid dispersion; multifaceted approach can avert solubility and dissolution impediments of mesalamine and proving itself as pivotal facet in amelioration of solubility and dissolution profiles of BCS IV entities in pharmaceutical applications.
Cite this article:
Supriya Shirke, Kishor Burade. Amelioration of Mesalamine Solubility and Dissolution Rate through Solid Dispersion: A In vitro Assessment. Research Journal of Pharmacy and Technology. 2026;19(8):3417-3. doi: 10.52711/0974-360X.2026.00485
Cite(Electronic):
Supriya Shirke, Kishor Burade. Amelioration of Mesalamine Solubility and Dissolution Rate through Solid Dispersion: A In vitro Assessment. Research Journal of Pharmacy and Technology. 2026;19(8):3417-3. doi: 10.52711/0974-360X.2026.00485 Available on: https://rjptonline.org/AbstractView.aspx?PID=2026-19-8-2
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