Author(s):
Tridoso Sapto Agus Priyono, Helmy Yusuf, Dwi Setyawan
Email(s):
helmy-yusuf@ff.unair.ac.id
DOI:
10.52711/0974-360X.2026.00444 
Address:
Tridoso Sapto Agus Priyono1, Helmy Yusuf1,2*, Dwi Setyawan1,2
1Department of Pharmaceutical Sciences, Faculty of Pharmacy, Airlangga University, Surabaya 60115, Indonesia.
2Pharmaceutics and Delivery Systems for Drugs, Cosmetics, and Nanomedicine Research Group, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Airlangga University, Surabaya 60115, Indonesia.
*Corresponding Author
Published In:
Volume - 19,
Issue - 7,
Year - 2026
ABSTRACT:
Rutin (RUT) is a lipophilic flavonoid glycoside compound and classified in the Biopharmaceutical Classification System (BCS) class II. Pharmacological activities of RUT are antioxidant, antitumor, anti-inflammatory, nephroprotector, and immunomodulatory. RUT has low solubility in water and undergo a hydrolysis in acidic stomach, which led to the low bioavailability. The aim of this study was to formulate RUT in enteric nanoparticle with improved dissolution and by passing the acidic gastric environment as solutions to those problems. RUT enteric nanoparticles (RENP) were developed in a combined matrix of Eudragit L100 (EL100), Poloxamer 188 (P188), and Poloxamer 407 (P407). The RENP suspension was solidified using freeze-drying technique to obtain the dry products. All formulations were evaluated in terms of their particle size after reconstitution with water. They were also evaluated in terms of yield, morphology, thermal properties and crystallinity of the solid states, and identified the molecules interactions. Moreover, a medium with a pH comparable to the intestine was used to examine the dissolution profiles of the created formulations. The findings demonstrated that the generated RENPs had a particle size of less than 600 nm. The morphology showed that the RUT entrapped in RENPs was in amorphous form which was confirmed by DSC and XRD data. The entrapped RUT indicated no structural changes which means that no chemical bounds were formed among molecules as indicated by FTIR. These data were in strong supports to the dissolution profiles of the developed RENPs. The percentage of dissolved RUT in all RENP formulations were incrased by 1,5 times as compared to raw RUT. The study concluded that the developed RENP formulations using EL100 and P188, P407 as combination matrix promotes the increase of dissolved RUT from RENP formulations and suitable for enteric platform of delivery systems.
Cite this article:
Tridoso Sapto Agus Priyono, Helmy Yusuf, Dwi Setyawan. Characteristics and Lattice Structure of Rutin in Enteric Nanoparticles with Improved Dissolution Properties. Research Journal of Pharmacy and Technology. 2026;19(7):3127-4. doi: 10.52711/0974-360X.2026.00444
Cite(Electronic):
Tridoso Sapto Agus Priyono, Helmy Yusuf, Dwi Setyawan. Characteristics and Lattice Structure of Rutin in Enteric Nanoparticles with Improved Dissolution Properties. Research Journal of Pharmacy and Technology. 2026;19(7):3127-4. doi: 10.52711/0974-360X.2026.00444 Available on: https://rjptonline.org/AbstractView.aspx?PID=2026-19-7-31
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