Author(s):
Sapana D. Deore, Shivraj P. Jadhav, Rushikesh L. Bachhav, Mayur S. Bhamare, Sunil K. Mahajan, Deepak D. Sonawane
Email(s):
deoresapana2001@gmail.com , rbachhav2001@gmail.com
DOI:
10.52711/0974-360X.2026.00429 
Address:
Sapana D. Deore1*, Shivraj P. Jadhav1, Rushikesh L. Bachhav2, Mayur S. Bhamare2, Sunil K. Mahajan3, Deepak D. Sonawane1
1Department of Pharmaceutics, SSS’s Divine College of Pharmacy, Nampur Road, Satana, Nashik, Maharashtra, India – 423301.
2Department of Pharmaceutical Quality Assurance, SSS’s Divine College of Pharmacy, Nampur Road, Satana, Nashik, Maharashtra, India – 423301.
3Department of Pharmaceutical Chemistry, SSS’s Divine College of Pharmacy, Nampur Road, Satana, Nashik, Maharashtra, India – 423301.
*Corresponding Author
Published In:
Volume - 19,
Issue - 7,
Year - 2026
ABSTRACT:
Objectives: To develop and optimise a ciprofloxacin hydrochloride nanoemulgel formulation for enhanced topical treatment of bacterial skin infections using a quality by design approach. Methods: A three-factor, three-level Box-Behnken design was employed to optimise the nanoemulsion composition. Almond oil was selected as the oil phase based on solubility studies (12.45±0.86mg/mL), with Brij-30 and PEG 400 as surfactant and cosurfactant, respectively. The optimised nanoemulsion was incorporated into a gel matrix using varying concentrations of Carbopol 934. Formulations were characterised for physicochemical properties, ex-vivo permeation, and stability. Results: The optimised nanoemulsion formulation (SF10) exhibited a globule size of 158.9±1.9nm, PDI of 0.178±0.012, and zeta potential of -33.6±1.3mV. Among nanoemulgel formulations, NEG2 demonstrated optimal characteristics with pH 6.4±0.1, viscosity 5625±285 cps, and Spreadability 25.4 ±1.5g.cm/s. Ex-vivo studies showed superior permeation (94.52% at 12hours) with a steady-state flux of 342.68 ±16.84µg/cm²/h. The formulation-maintained stability over 6 months at accelerated conditions, with drug content remaining above 97.85%. Conclusion: The developed nanoemulgel formulation demonstrates promising potential for enhanced topical delivery of ciprofloxacin hydrochloride through optimised physicochemical properties and superior skin permeation. This novel delivery system could potentially improve therapeutic outcomes in bacterial skin infections by providing sustained drug release and enhanced skin penetration.
Cite this article:
Sapana D. Deore, Shivraj P. Jadhav, Rushikesh L. Bachhav, Mayur S. Bhamare, Sunil K. Mahajan, Deepak D. Sonawane. Development and Optimization of Ciprofloxacin Hydrochloride Nanoemulgel to Treat Topical Bacterial Skin Infections. Research Journal of Pharmacy and Technology. 2026;19(7):3013-2. doi: 10.52711/0974-360X.2026.00429
Cite(Electronic):
Sapana D. Deore, Shivraj P. Jadhav, Rushikesh L. Bachhav, Mayur S. Bhamare, Sunil K. Mahajan, Deepak D. Sonawane. Development and Optimization of Ciprofloxacin Hydrochloride Nanoemulgel to Treat Topical Bacterial Skin Infections. Research Journal of Pharmacy and Technology. 2026;19(7):3013-2. doi: 10.52711/0974-360X.2026.00429 Available on: https://rjptonline.org/AbstractView.aspx?PID=2026-19-7-16
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