Author(s):
Anjali P. Patil, Vikas R. Dhole, Vivek T. Kumbhar, Sanganna C. Burli
Email(s):
patilanjali9860@gmail.com , vikasdhole@amcoph.org , vivektk1058@gmail.com , scburli@gmail.com
DOI:
10.52711/0974-360X.2026.00427~ 
Address:
Anjali P. Patil, Vikas R. Dhole, Vivek T. Kumbhar, Sanganna C. Burli
Ashokrao Mane College of Pharmacy, Peth Vadgaon, Maharashtra, India.
*Corresponding Author
Published In:
Volume - 19,
Issue - 7,
Year - 2026
ABSTRACT:
Chronic pain and inflammation remain major therapeutic challenges. Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently recommended but are associated with gastrointestinal, renal, and cardiovascular adverse effects. This study evaluated the anti-inflammatory as well as analgesic activities of two Ayurvedic formulations, Rhumayog Tablet (RT) and Sandhivatari Tablet (ST), using validated animal models. Using phytochemical screening, it was found that flavonoids, glycosides, alkaloids, tannins, phenols, steroids, and saponins, compounds known for anti-inflammatory and analgesic properties. Anti-inflammatory activity, was assessed using carrageenan-induced pawedema in Wistar rats, while analgesic activity, was examined in Swiss albino mice using the hot plate, tail immersion, and acetic acid–induced writhing models. RT (350mg/kg) and ST (250mg/kg) significantly reduced paw edema (23–24%), comparable to indomethacin (28%). Both formulations also produced significant central and peripheral analgesic effects, as evidenced by prolonged latency in thermal models and reduced writhing frequency, with RT showing slightly superior efficacy. Statistical analysis, using one-way ANOVA followed by, Dunnett’s multiple comparison test confirmed significance (p < 0.001). These findings support the, traditional use of RT and ST in inflammatory conditions and highlight their potential as safer alternatives to conventional NSAIDs.
Cite this article:
Anjali P. Patil, Vikas R. Dhole, Vivek T. Kumbhar, Sanganna C. Burli. In Vivo Comparative Study of Ayurvedic Rhumayog and Sandhivatari Tablets: Potential Role in Managing Inflammation and Pain. Research Journal of Pharmacy and Technology. 2026;19(7):2999-6. doi: 10.52711/0974-360X.2026.00427~
Cite(Electronic):
Anjali P. Patil, Vikas R. Dhole, Vivek T. Kumbhar, Sanganna C. Burli. In Vivo Comparative Study of Ayurvedic Rhumayog and Sandhivatari Tablets: Potential Role in Managing Inflammation and Pain. Research Journal of Pharmacy and Technology. 2026;19(7):2999-6. doi: 10.52711/0974-360X.2026.00427~ Available on: https://rjptonline.org/AbstractView.aspx?PID=2026-19-7-14
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