Author(s):
Betelhem Hailu T, Pallikonda Namrata, Subhosh Chandra M, Kamalakararao K, Naveen Kumar A.D, Sudhish Rai, Krishna Chaithanya K
Email(s):
krishnachaithanyawc07@gmail.com
DOI:
10.52711/0974-360X.2026.00352 
Address:
Betelhem Hailu T1, Pallikonda Namrata2, Subhosh Chandra M3, Kamalakararao K4, Naveen Kumar A.D5, Sudhish Rai 6, Krishna Chaithanya K7,8*
1Department of Biology, Post Graduate Applied Microbiology Program, College of Natural and Computational Sciences, Aksum University, Axum, Ethiopia.
2Department of Microbiology, GSL Medical College and Hospital, Rajamahendravaram, Andhra Pradesh, India.
3Department of Microbiology, Yogi Vemana University, Kadapa, Andhra Pradesh, India.
4Department of Biochemistry, University College of Science and Technology, Adikavi Nannaya University, Rajamahendravaram, Andhra Pradesh, India.
5School of Medicine, Texila American University, Lusaka, Zambia, Central Africa.
6Jagrani Devi Pharmacy College, Baradwar, Sakti, C.G., India.
7Department of Chemistry, College of Natural and Computational Sciences, Aksum University, Axum, Tigray Region, Ethiopia.
8Department of Biochemistry, Saveetha Medical College and Hospital, Saveetha Institute of Medical a
Published In:
Volume - 19,
Issue - 6,
Year - 2026
ABSTRACT:
The increasing incidence of oxidative stress-induced multi-drug resistant bacterial infections presents a serious public health challenge that demands the immediate investigation of novel bioactive compounds from medicinal plants. Euclea racemosa a member of the Ebenaceae family, to cure ranges of illnesses. This study was to analyze phytochemical composition and asses the in vitro bacterial activities of organic crude leaf extracts from E.racemosa. Gram-positive bacteria (Bacillus subtilis, Staphylococcus aureus, Staphylococcus epidermidis, and Streptococcus mutans) and four Gram-negative bacteria (Escherichia coli, Klebsiella pneumoniae, Vibrio cholerae, and Salmonella enterica) were tested against crude leaf extracts of E.racemosa. Out of the four organic crude leaf extracts of E. racemosa, the ethyl acetate extract at 100 mg/ml demonstrated the largest inhibition zones against single Gram-negative bacteria, E. coli (22.1 mm), while the ethanolic extract at 100 mg/ml demonstrated strong broad-spectrum antibacterial effects against Gram-positive S. aureus (22.4 mm) and Gram-negative S. enterica (23.5 mm). The results of phytochemical analysis indicated the presence of flavonoids, tannins, and phenolic compounds, which could be accountable for the notable antibacterial activities observed. These findings validate the traditional use of E. racemosa leaf extracts and suggest their potential in developing novel plant derived antibacterial agents for therapeutic applications.
Cite this article:
Betelhem Hailu T, Pallikonda Namrata, Subhosh Chandra M, Kamalakararao K, Naveen Kumar A.D, Sudhish Rai, Krishna Chaithanya K,. Phytochemical Analysis and In vitro Anti bacterial Efficacy of Euclea racemosa leaf Extracts Against Selected Multidrug Resistant Bacteria Pathogens. Research Journal Pharmacy and Technology. 2026;19(6):2462-8. doi: 10.52711/0974-360X.2026.00352
Cite(Electronic):
Betelhem Hailu T, Pallikonda Namrata, Subhosh Chandra M, Kamalakararao K, Naveen Kumar A.D, Sudhish Rai, Krishna Chaithanya K,. Phytochemical Analysis and In vitro Anti bacterial Efficacy of Euclea racemosa leaf Extracts Against Selected Multidrug Resistant Bacteria Pathogens. Research Journal Pharmacy and Technology. 2026;19(6):2462-8. doi: 10.52711/0974-360X.2026.00352 Available on: https://rjptonline.org/AbstractView.aspx?PID=2026-19-6-9
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