Author(s):
Musallam D. Al Shawawreha, Samer Y. Al-Qaraleh, Sara S. Alqaraleh, Almuthna A. Alqtaitat, Aiman Al-Qtaitat
Email(s):
garalleh75@mutah.edu.jo.
DOI:
10.52711/0974-360X.2026.00350 
Address:
Musallam D. Al Shawawreha1, Samer Y. Al-Qaraleh*2, Sara S. Alqaraleh3, Almuthna A. Alqtaitat3, Aiman Al-Qtaitat2
1Department of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Al-Ahliyya Amman University, Amman, Jordan.
2Department of Dental and Medical Sciences, Faculty of Dentistry, Mutah University, Al-Karak 61710, Jordan.
3Faculty of Medicine, Mutah University, Al-Karak 61710, Jordan.
*Corresponding Author
Published In:
Volume - 19,
Issue - 6,
Year - 2026
ABSTRACT:
Thalassemia is a hereditary hemoglobinopathy characterized by impaired hemoglobin synthesis, which results in chronic anemia. Recent studies highlight that trace elements such as zinc, copper, magnesium, and phosphorus play key roles in hematopoiesis and may contribute to disease complications in thalassemia. This study investigated the association between selected mineral levels and hematological indicators in thalassemia patients compared with healthy controls. A cross-sectional analysis was performed on 81 individuals (47 diagnosed with thalassemia and 34 controls). Complete blood counts were assessed using a Mindray BC-6800 analyzer, while serum zinc, copper, magnesium, and phosphorus concentrations were measured by colorimetric and spectrophotometric methods. Statistical comparisons were performed using the Mann–Whitney U test, and correlations were analyzed. Thalassemia patients exhibited significantly elevated WBC counts (12.4 ± 8.95 × 10³/µL), reduced hemoglobin (9.58±2.83g/dL), and lower PCV (29.58±10.05%), consistent with chronic anemia. RDW was increased (20.37±9.81%) and MCV was decreased (72.06±13.38 fL), indicating anisocytosis and microcytosis. higher zinc and magnesium levels were strongly associated with improved hematological indices (Hb, PCV, RDW) in thalassemia patients, suggesting a regulatory or compensatory link between mineral metabolism and erythropoiesis. Phosphorus levels showed greater variability. Correlation analysis revealed significant associations between zinc and hematological indices (e.g., Hb, PCV, PLT), and between magnesium and several parameters, including WBC and RDW. The study demonstrates a distinct profile of mineral imbalances in thalassemia patients and their correlation with hematological abnormalities. These findings suggest that monitoring and correcting trace element levels may be beneficial in managing the disease.
Cite this article:
Musallam D. Al Shawawreha, Samer Y. Al-Qaraleh, Sara S. Alqaraleh, Almuthna A. Alqtaitat, Aiman Al-Qtaitat. Exploring the Relationship between Trace Mineral Imbalance and Hematological Alterations in Thalassemia. Research Journal Pharmacy and Technology. 2026;19(6):2449-4. doi: 10.52711/0974-360X.2026.00350
Cite(Electronic):
Musallam D. Al Shawawreha, Samer Y. Al-Qaraleh, Sara S. Alqaraleh, Almuthna A. Alqtaitat, Aiman Al-Qtaitat. Exploring the Relationship between Trace Mineral Imbalance and Hematological Alterations in Thalassemia. Research Journal Pharmacy and Technology. 2026;19(6):2449-4. doi: 10.52711/0974-360X.2026.00350 Available on: https://rjptonline.org/AbstractView.aspx?PID=2026-19-6-7
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