Author(s):
Palanisamy Ravikumar, Vellasamy Devadoss, Nalini R. Uthaman, Kannan Priya
Email(s):
headircb@gmail.com
DOI:
10.52711/0974-360X.2026.00404 
Address:
Palanisamy Ravikumar1*, Vellasamy Devadoss2, Nalini R. Uthaman3, Kannan Priya4
1Sr. Scientist, Iyarvi Research Center for Bioinformatics (IRCB), Erode - 638452, Tamil Nadu, India.
2Senior Lecturer, Department of Chemistry, University of Technology and Applied Sciences (UTAS), Muscat - 133, Oman.
3Assistant Professor, Department of Applied Sciences, University of Technology and Applied Sciences (UTAS), Muscat - 133, Oman.
4Jr. Scientific Officer, Iyarvi Research Center for Bioinformatics (IRCB), Erode - 638 452, Tamil Nadu, India.
*Corresponding Author
Published In:
Volume - 19,
Issue - 6,
Year - 2026
ABSTRACT:
A worldwide public health concern, burn injuries are thought to be responsible for 300,000 deaths a year, with the great majority occurring in low- and middle-income nations. Global health care systems bear a heavy financial burden, and patients who sustain severe burn injuries face major challenges in their physical, mental, and financial lives. The present study was designed to evaluate potential compounds from banana leaf extract for burn wound healing using chromatography and in silico studies. Banana leaf extract was collected using the cold percolation method and ethanol was used as a solvent. Column chromatography was used to collect the fractions and GC-MS analysis was done to find the compounds present in the fractions. Molecular docking techniques were used to find the potential compounds present in the fractions for burn wound healing. Uniprot and PDB database was used to find the 3D structure of the target protein for burn wound healing, the PubChem database was used to find the 3D structure of the compounds, and the PyRx and Discovery Studio software were used to find the interaction of compounds with the target protein responsible for the burn wound healing. From the results, the phytocompound Acetamide, 2-(adamantan-1-yl)-N-(1-adamantan-1-ylethyl)- (-8.2kcal/mol), 3-Quinolinecarboxylic acid, 6,8-difluoro-4-hydroxy-, ethyl ester (-7.3kcal/mol) and 1H-Isoindole-1,3(2H)-dione, 2-butyl-4,5,6,7-tetrahydro- (-7.2kcal/mol) showed very good binding affinity with the target protein Sestrin 2 when compared to the synthetic drug Silver Sulfadiazine (-6.9kcal/mol) and the toxicity was also not observed for the most of the compounds in the ADMET analysis. Hence, the present study concludes that the compounds Acetamide, 2-(adamantan-1-yl)-N-(1-adamantan-1-ylethyl)-, 3-Quinolinecarboxylic acid, 6,8-difluoro-4-hydroxy-, ethyl ester and 1H-Isoindole-1,3(2H)-dione, 2-butyl-4,5,6,7-tetrahydro- from the banana leaf may have the potential ability for treating burn wounds. Further, pre-clinical study is required to confirm the efficacy of these compounds in treating burn wounds.
Cite this article:
Palanisamy Ravikumar, Vellasamy Devadoss, Nalini R. Uthaman, Kannan Priya. Evaluating Potential Phytocompounds from the Banana leaf Extract for Burn Wound Healing using Chromatography and In silico Studies. Research Journal Pharmacy and Technology. 2026;19(6):2825-4. doi: 10.52711/0974-360X.2026.00404
Cite(Electronic):
Palanisamy Ravikumar, Vellasamy Devadoss, Nalini R. Uthaman, Kannan Priya. Evaluating Potential Phytocompounds from the Banana leaf Extract for Burn Wound Healing using Chromatography and In silico Studies. Research Journal Pharmacy and Technology. 2026;19(6):2825-4. doi: 10.52711/0974-360X.2026.00404 Available on: https://rjptonline.org/AbstractView.aspx?PID=2026-19-6-61
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