Author(s):
Elvira Hermawati, Ilham Ramadhan, Ade Danova, Robby Roswanda
Email(s):
elvira.hermawati@itb.ac.id , adedanova@itb.ac.id
DOI:
10.52711/0974-360X.2026.00395 
Address:
Elvira Hermawati*, Ilham Ramadhan, Ade Danova*, Robby Roswanda
Organic Chemistry Division, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Jl. Ganesha No. 10, Bandung 40132, West Java, Indonesia.
*Corresponding Author
Published In:
Volume - 19,
Issue - 6,
Year - 2026
ABSTRACT:
Chalcone-pyrrole derivatives are unique structures and possess a wide range of biological activities. A total of eight new chalcone-pyrrole amide derivatives were successfully synthesized through the application of the Claisen-Schmidt condensation followed by an amidation reaction and characterized by the spectroscopic method. The synthesized compounds were investigated for their biological activities targeting caspase-7. Among eight compounds (10a-10d, 11a-11d), only compound 10c showed 8.13% inhibition against caspase-7.
Cite this article:
Elvira Hermawati, Ilham Ramadhan, Ade Danova, Robby Roswanda. New Chalcone-Pyrrole Amide Hybrids: Synthesis and Screening of Caspase-7 Inhibitory Activity. Research Journal Pharmacy and Technology. 2026;19(6):2767-4. doi: 10.52711/0974-360X.2026.00395
Cite(Electronic):
Elvira Hermawati, Ilham Ramadhan, Ade Danova, Robby Roswanda. New Chalcone-Pyrrole Amide Hybrids: Synthesis and Screening of Caspase-7 Inhibitory Activity. Research Journal Pharmacy and Technology. 2026;19(6):2767-4. doi: 10.52711/0974-360X.2026.00395 Available on: https://rjptonline.org/AbstractView.aspx?PID=2026-19-6-52
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