ABSTRACT:
Introduction: A build-up of plaque in the walls of the heart’s major blood veins that restricts blood flow to the heart is known as CAD, also referred to an Atherosclerosis heart disease. Atherosclerosis can result in acute myocardial infraction, is largely influenced by inflammation. The multiple markers for inflammation of CAD, includes CRP, IL-6, and E-selectin. Yet none of these markers including CRP, are routinely indicated for screening of Apparently healthy subjects with intermediate risk for CAD. The number of WBC is a cellular marker for systemic inflammation. An increased number of WBC`s are also an independent predictor of major adverse Cardiovascular events (MACE). Aim and Objective: To investigate the relationship between some prominent haematological blood count Parameters (WBC count), Neutrophil to lymphocyte ratio [NLR]) and the severity of CAD by using Gensini scores. To evaluate the correlation between WBC count and Gensini score. Methods: We consecutively enrolled a total of 150 patients who were admitted to Malla Reddy Narayana Multi speciality hospital with several symptoms of CAD, coronary angiography procedure were done to diagnose and confirm cad between august 2023 to January 2024.All patients had anginal symptoms and/or positive myocardial ischemia. Results: In this study, we revealed that WBC count and, NLR ratio were higher (76% and 72%, respectively, out of 100%) in CAD patients diagnosed by angiography procedures, so these markers have an essential function in predicting and preventing cardiovascular disease. In our study, we revealed the NLR ratio has more prevalence as an inflammatory marker in the detection of CAD. Here, a higher level of NLR (>2.3) from baseline has been seen in 72% of CAD patients. In our study, this was the case for over 76% of patients with an activated WBC count of >9000 from baseline. Conclusion: A higher WBC count is a risk element for CAD by itself and its severity. The differential count, NLR, has shown to be an independent inflammatory biomarker in atherosclerotic CAD along with WBC count. The incidence of CAD is more in individuals with impairments in contrast to those lacking them. Neutrophil-to-lymphocyte ratio, or WBC, is an affordable, accessible, and calculable inflammatory indicator used to help patients with a range of cardiovascular conditions be grouped according to their risk.