Author(s):
Vidya Murugeshwari, Abhirami PV, Shridhar Deshpande N. Anusha S, Ranjitha Acharya, Arvinda Pai, Pradeep Kumar MR, Pankaj Kumar
Email(s):
pankajpgr@gmail.com
DOI:
10.52711/0974-360X.2026.00372 
Address:
Vidya Murugeshwari1, Abhirami PV1, Shridhar Deshpande N1. Anusha S1, Ranjitha Acharya1, Arvinda Pai2, Pradeep Kumar MR3, Pankaj Kumar1*
1Nitte (Deemed to be University), NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Department of Pharmaceutical Chemistry, Mangalore, India.
2Department of Pharmaceutical Chemistry, MCOPS, MAHE, Manipal, Karnataka, India.
3Department of Pharmaceutical Chemistry, KLE College of Pharmacy, KAHER, Hubballi, Karnataka.
*Corresponding Author
Published In:
Volume - 19,
Issue - 6,
Year - 2026
ABSTRACT:
Depression is a common CNS disorder caused by serotonin and dopamine imbalances. In this study, we designed 1,3,4-oxadiazole-linked chromone derivatives. Molecular docking against 5-hydroxytryptamine 1A receptors revealed that various designed derivatives had a higher docking score than Imipramine. Further analysis predicted that these derivatives had the highest binding efficiency and adhered to the rule of five, suggesting favourable drug-like properties. Based on the In-silico study, nine different derivatives were synthesized using three-step reactions: firstly, Schiff base, followed by cyclization, and characterized by IR, mass, and ¹H NMR spectroscopy. Finally, these compounds were evaluated for antidepressant and antioxidant activity using the forced swim test, DPPH, and nitric oxide scavenging methods. The forced swim test revealed that VAD2 and VAD8 have substantial antidepressant activity at low and medium doses. DPPH and nitric oxide scavenging methods showed that compounds VAD1 and VAD9 had notable antioxidant activity.
Cite this article:
Vidya Murugeshwari, Abhirami PV, Shridhar Deshpande N. Anusha S, Ranjitha Acharya, Arvinda Pai, Pradeep Kumar MR, Pankaj Kumar. Design and Synthesis of Oxadiazole-integrated Chromone Derivatives Targeting 5-HT1A Receptor as Anti-depressant Agents. Research Journal Pharmacy and Technology. 2026;19(6):2598-4. doi: 10.52711/0974-360X.2026.00372
Cite(Electronic):
Vidya Murugeshwari, Abhirami PV, Shridhar Deshpande N. Anusha S, Ranjitha Acharya, Arvinda Pai, Pradeep Kumar MR, Pankaj Kumar. Design and Synthesis of Oxadiazole-integrated Chromone Derivatives Targeting 5-HT1A Receptor as Anti-depressant Agents. Research Journal Pharmacy and Technology. 2026;19(6):2598-4. doi: 10.52711/0974-360X.2026.00372 Available on: https://rjptonline.org/AbstractView.aspx?PID=2026-19-6-29
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