Author(s):
Mohini Patidar, Raghvendra Dubey, Nitin Deshmukh, Ayushi Patud, Sunita Minz, Rajesh Kumar
Email(s):
patidarmohini321@gmail.com
DOI:
10.52711/0974-360X.2026.00368 
Address:
Mohini Patidar1*, Raghvendra Dubey2, Nitin Deshmukh1, Ayushi Patud1, Sunita Minz3, Rajesh Kumar3
1Department of Pharmaceutical Chemistry, GRY Institute of Pharmacy, Borawan, Khargone – 451228.
2Department of Pharmaceutical Chemistry, Sage University Institute of Pharmaceutical Sciences, Indore - 452016.
3Department of Pharmacy, Indira Gandhi National Tribal University (A Central University), Amarkantak, Anuppur (M.P.) - 484887, India.
*Corresponding Author
Published In:
Volume - 19,
Issue - 6,
Year - 2026
ABSTRACT:
The current investigation focuses on the synthesis, physicochemical characterization, and biological screening of innovative Azetidin-2-one scaffolds as prospective antidiabetic agents. All synthesized compounds adhered to Lipinski’s Rule of Five and demonstrated favorable drug-likeness and pharmacokinetic profiles through in silico predictions. Among the series, compound 35 displayed potent in-vitro inhibitory effects on enzyme a-amylase, a-glucosidase, and aldose reductase, in addition to high docking scores against enzymes implicated in diabetes, particularly GSK-3ß. In vivo studies in STZ-induced diabetic rats confirmed its significant glucose-lowering effect, improved insulin levels, lipid profile normalization, and enhanced liver glycogen content. Acute oral toxicity testing indicated a high safety margin (LD50 > 2000mg/kg). Compound 35 shows multifunctional potential for type 2 diabetes based on computational, biochemical, and pharmacological data.
Cite this article:
Mohini Patidar, Raghvendra Dubey, Nitin Deshmukh, Ayushi Patud, Sunita Minz, Rajesh Kumar. Synthesis and Biological Evaluation of Schiff Base Azetidinone derivatives on Multi-target Intervention for Diabetes Mellitus. Research Journal Pharmacy and Technology. 2026;19(6):2569-7. doi: 10.52711/0974-360X.2026.00368
Cite(Electronic):
Mohini Patidar, Raghvendra Dubey, Nitin Deshmukh, Ayushi Patud, Sunita Minz, Rajesh Kumar. Synthesis and Biological Evaluation of Schiff Base Azetidinone derivatives on Multi-target Intervention for Diabetes Mellitus. Research Journal Pharmacy and Technology. 2026;19(6):2569-7. doi: 10.52711/0974-360X.2026.00368 Available on: https://rjptonline.org/AbstractView.aspx?PID=2026-19-6-25
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