Author(s):
Charul Mathur, Amit Lather, Tanuj Hooda, Bhoj Raj, Sukender Kumar, Rakesh Redhu, Rajiv Sharma, Ramchander Khatri, J Saminathan
Email(s):
tanujhooda2010@gmail.com , dramitlather@gmail.com
DOI:
10.52711/0974-360X.2026.00219 
Address:
Charul Mathur1, Amit Lather2*, Tanuj Hooda3*, Bhoj Raj4, Sukender Kumar4, Rakesh Redhu5, Rajiv Sharma6, Ramchander Khatri3, J Saminathan3
1Department of Pharmaceutical Sciences, Jaipur College of Pharmacy, Jaipur, Rajasthan, India.
2Hindu College of Pharmacy, Sonipat -131001, India.
3Delhi Pharmaceutical Sciences and Research University (DPSRU), New Delhi.
4Department of Pharmaceutical Science, Chaudhary Bansi Lal University, Bhiwani, Haryana, India.
5Geeta Institute of Pharmacy, Geeta University, Naultha-132145, Panipat, India.
6University Institute of Pharma Sciences and Research, Chandigarh University, Mohali, Punjab, India.
*Corresponding Author
Published In:
Volume - 19,
Issue - 4,
Year - 2026
ABSTRACT:
Background: The leaves of Platycladus orientalis have been widely used in Chinese traditional medicines as anti-tussive and expectorant. Scientific studies have also showed its anti-inflammatory activity in various cell-based and animal models. However, there is no evidence for anti- inflammatory and analgesic activities of P.orientalis leaves collected from Indian origin. Therefore, the objective of this study was to evaluate the anti-inflammatory and analgesic potential of P.orientalis of Indian origin. Methods: Carrageenan, dextran, formalin and histamine induced paw edemas was figured out for Anti-inflammatory activity. Analgesic activity was determined using acetic acid and formalin induced paw licking response in rats. Results: Phytochemical screening revealed that the extract contains many phytochemicals including alkaloids, tannins, carbohydrates, glycosides and flavonoids. The ethanol extract significantly suppressed the paw edema induced by carrageenan, dextran, histamine and formalin in a dose dependent manner. Analgesic activity and chronic anti-inflammatory activities were also exhibited by Ethanol extract. Conclusion: The above research demonstrates that the anti-inflammatory and analgesic activity of alcoholic extract of P.orieantalis leaves was inconsequential or unimportant. These results finding further could be used to find the mechanistic investigations.
Cite this article:
Charul Mathur, Amit Lather, Tanuj Hooda, Bhoj Raj, Sukender Kumar, Rakesh Redhu, Rajiv Sharma, Ramchander Khatri, J Saminathan. Anti-inflammatory and Analgesic activities of alcoholic leaves extract from Platycladus orientalis: An In-vivo Evaluation. Research Journal of Pharmacy and Technology. 2026;19(4):1527-3. doi: 10.52711/0974-360X.2026.00219
Cite(Electronic):
Charul Mathur, Amit Lather, Tanuj Hooda, Bhoj Raj, Sukender Kumar, Rakesh Redhu, Rajiv Sharma, Ramchander Khatri, J Saminathan. Anti-inflammatory and Analgesic activities of alcoholic leaves extract from Platycladus orientalis: An In-vivo Evaluation. Research Journal of Pharmacy and Technology. 2026;19(4):1527-3. doi: 10.52711/0974-360X.2026.00219 Available on: https://rjptonline.org/AbstractView.aspx?PID=2026-19-4-8
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