Author(s):
Preeti Bansal, Shipra Thapar, Geeta Deswal
Email(s):
deswalgeeta@gmail.com
DOI:
10.52711/0974-360X.2026.00278 
Address:
Preeti Bansal1, Shipra Thapar1, Geeta Deswal2*
1School of Pharmaceutical Sciences, CT University, Ludhiana - 142024, Punjab, India.
2Guru Gobind Singh College of Pharmacy, Yamunanagar, Haryana, India.
*Corresponding Author
Published In:
Volume - 19,
Issue - 4,
Year - 2026
ABSTRACT:
Osteoarthritis (OA) is a progressive joint disorder primarily linked to aging, marked by cartilage deterioration, inflammation, and pain. Despite various pharmacological and non-pharmacological treatments offering symptom relief, no therapy currently exists to halt or reverse disease progression. This review examines the therapeutic potential of botanical products in OA management, focusing on their active compounds, mechanisms of action, and clinical relevance. A detailed evaluation of botanical extracts and their key phytochemicals was conducted, emphasizing their anti-inflammatory, chondroprotective, and analgesic effects. The review also explores emerging evidence on functional foods with therapeutic value in OA. Several plant-derived compounds, including polyphenols, flavonoids, and terpenoids, have shown promise in modulating molecular pathways associated with OA. Natural agents such as curcumin, resveratrol, and epigallocatechin-3-gallate exhibit anti-inflammatory, antioxidant, and cartilage-protective properties. However, inconsistencies in botanical formulations and a lack of standardized clinical trials hinder their broader clinical application. With OA prevalence on the rise, botanical therapies offer a compelling avenue for symptom relief and potential disease modification. To integrate these treatments into mainstream medicine, further research is needed to identify and standardize bioactive compounds, optimize dosing, and assess long-term safety and efficacy through rigorous clinical trials. Botanical interventions hold significant promise as natural, accessible strategies for OA management.
Cite this article:
Preeti Bansal, Shipra Thapar, Geeta Deswal. Phytochemicals and Herbal Therapeutics in Osteoarthritis: Emerging Bioactive Compounds and Mechanisms of Action. Research Journal of Pharmacy and Technology. 2026;19(4):1935-5. doi: 10.52711/0974-360X.2026.00278
Cite(Electronic):
Preeti Bansal, Shipra Thapar, Geeta Deswal. Phytochemicals and Herbal Therapeutics in Osteoarthritis: Emerging Bioactive Compounds and Mechanisms of Action. Research Journal of Pharmacy and Technology. 2026;19(4):1935-5. doi: 10.52711/0974-360X.2026.00278 Available on: https://rjptonline.org/AbstractView.aspx?PID=2026-19-4-67
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