Author(s):
V. Lakshmanakumar, P. L. Balasubramanian
Email(s):
drlakshh@gmail.com
DOI:
10.52711/0974-360X.2026.00267 
Address:
V. Lakshmanakumar*1, P. L. Balasubramanian2
1Ph.D Scholar, Department of Siddha Medicine, Tamil University, Thanjavur, Tamil Nadu, India.
2Assistant Professor, Department of Siddha Medicine, Tamil University, Thanjavur, India.
*Corresponding Author
Published In:
Volume - 19,
Issue - 4,
Year - 2026
ABSTRACT:
Background: Traditional Siddha medicine is a useful therapeutic option for treating non-communicable diseases (NCDs). One distinctive aspect of the Siddha medical system is its utilization of various metals, minerals, padanam, ubarasam, and karasaram to treat both acute and chronic illnesses. Methodology: Abragam (Mica or Biotite) was the topic of a thorough literature research that was conducted using the Siddha pharmacopoeias as well as electronic databases include Pub Med, Google Scholar, and Science. Results: Based on review of the literature and scientific research on Abragam reveals that studies were done on its Physiochemical character, Standardization and Toxicity. Conclusion: Purification processes of abragam have a specific impact on structural deformation, and heating and quenching can produce nanoparticles. When making medicines with Abragam in traditional medicine undergoes chemical and structural changes to the Abragam. In accordance to the literature and scientific review, Abragam is used in the Siddha system to treat a variety of ailments. It also possesses anti-diabetic properties; it has been utilized to treat Madhumegam (Diabetes Mellitus) from ancient times. In order to completely prove that medicines based on Abragam are safe and free of harmful and long-term adverse effects, further scientific studies are needed.
Cite this article:
V. Lakshmanakumar, P. L. Balasubramanian. Scientific Significance of Abragam (Biotite) in Siddha Traditional Medicine: A Review. Research Journal of Pharmacy and Technology. 2026;19(4):1859-4. doi: 10.52711/0974-360X.2026.00267
Cite(Electronic):
V. Lakshmanakumar, P. L. Balasubramanian. Scientific Significance of Abragam (Biotite) in Siddha Traditional Medicine: A Review. Research Journal of Pharmacy and Technology. 2026;19(4):1859-4. doi: 10.52711/0974-360X.2026.00267 Available on: https://rjptonline.org/AbstractView.aspx?PID=2026-19-4-56
REFERENCES:
1. Uthamarayan. Siddha Maruthuvangasurukam. Indian Medicine and Homeopathy, Chennai; 2006. 321–334 p.
2. Wijenayake A, Pitawala A, Bandara R, Abayasekara C. The role of herbometallic preparations in traditional medicine – A review on mica drug processing and pharmaceutical applications. Journal of Ethnopharmacology. 2014 Sept; 155(2): 1001–10.
3. Wijenayake A, Abayasekara C, Pitawala A, Bandara BMR. Antimicrobial potential of four mica drugs and their chemical and mineralogical properties. BMC Complement Med Ther. 2022 Dec; 22(1): 65.
4. Zhu F shi, Si J min, Wang L jing, Wang D fei, Cheng P. Effect of mica monomer powder on chief and parietal cells as well as G and D cells in gastric mucosa of chronic atrophic gastritis in rats. Chin J Integr Med. 2008 June; 14(2): 111–6.
5. Sathish R, Madhavan R, Vasanthi HR, Amuthan A. In-vitro alpha-glucosidase inhibitory activity of abraga chendhooram, a Siddha drug. 2012;(3).
6. Amrita M, Arun M, Ashoke G, Shivesh JS. Significance of mica in aurvedic products: an overview. IJRAP. 2011; 2(2): 389–92.
7. Melka K. A scheme for the classification of micaceous minerals. Acta Geodyn Geomater. 2009; 6(1): 153.
8. Icenhower J, London D. An experimental study of element partitioning among biotite, muscovite, and coexisting peraluminous silicic melt at 200 MPa (H2O). American Mineralogist. 1995; 80(11-12): 1229–51.
9. Pitawala A, Fernando GW, Weerasinghe C. Chemical and Structural Changes of Biotite during Preparation of Ayurvedic Medicine.
10. Thiyagarajan R. GunapadamThathuVagupu. Chennai: Department of Indian Medicine and Homeopathy; 2009. 515, 517, 519, 523 p.
11. Devi MR, Reddy GD, Kumar PN, Sathiyarajeswaran P, Elankani P. Herbomineral formulations safety and efficacy employed in siddha system of medicine: Int Res J Pharm. 2019; 10(1): 16–24.
12. Sudha A, Murty VS, Chandra TS. Standardization of metal-based herbal medicines. Am J Infect Dis. 2009; 5(3): 193–9.
13. Devanesan S, Ponmurugan K, S. AlSalhi M, Al- Dhabi NA. Cytotoxic and Antimicrobial Efficacy of Silver Nanoparticles Synthesized Using a Traditional Phytoproduct, Asafoetida Gum. IJN. 2020 June; Volume 15: 4351–62.
14. Dasgupta A, Hammett-Stabler CA. Herbal supplements: efficacy, toxicity, interactions with western drugs, and effects on clinical laboratory tests. John Wiley and Sons; 2011.
15. Kumar G, Gupta Y. Evidence for safety of Ayurvedic herbal, herbo-metallic and Bhasma preparations on neurobehavioral activity and oxidative stress in rats. AYU. 2012; 33(4): 569.
16. Tanushree Chatterjee, Pradeep Kumar Sahu, Shilpi Chatterjee, Jai Godheja. Current and Future Biotechnological Approaches for Diabetes Mellitus. Asian J. Pharm. Tech. 2011; 1(4): 94-98.
17. Gowthami M. Antidote action of Abraka Parpam in various vehicles mentioned in Siddha literatures. International Journal of Development Research. 2021; 11(04): 46197–9.
18. Siddha Maruthuvanool Veliyitu Pirivu. Sarakku Suthi Muraigal. Department of Indian Medicine and Homeopathy; 2008. 99 p.
19. Kuppusamy KN, Uthamarayan KS. Siddha Vaithiyathirattu. Department of Indian Medicine and Homeopathy; 2009. 130–131 p.
20. The Siddha Formulary of India. Vol. Part-I. 36 p.
21. Murugesa Mudhaliyar K. Nanju Moorivu Nool. Chennai: Department of Indian Medicine and Homeopathy; 2012. 35–36 p.
22. WM Association. Declaration of Helsinki. Recommendations guiding physicians in biomedical research involving human subjects. JAMA. 1997; 35: 2–3.
23. Sathiyabama G., Chandru. Effects of Spirulina in Type 2 Diabetes mellitus among adult patients in selected community area. A and V Pub Journal of Nursing and Medical Research. 2024; 3(4): 170-6.
24. Jaya Preethi. Herbal Medicine for Diabetes Mellitus: A Review. Asian J. Pharm. Res. 2013; 3(2): 57-70.
25. Ng TB, Wong CM, Li WW, Yeung HW. Insulin-like molecules in Momordica charantia seeds. Journal of Ethnopharmacology. 15(1): 107–17.
26. Anbu N, Musthafa M, Kumar PM, Velpandian V. Clinical Evaluation of Palingu Abraga Parpam in the Management of Diabetes Mellitus (Niddm). Bulletin of Environment, Pharmacology and Life Sciences. 2012; 1(12): 37–42.
27. Ann V Chacko. Thiamine Deficiency and its Implications on Microvascular Complications of Diabetes Mellitus. Asian Journal of Research in Pharmaceutical Sciences. 2024; 14(3):256-2.
28. Devi S, Kannan M, Rajeswaran SP, Natarajan S, Vasudevan R, Muralidass SD. Instrumental standardization of the herbo mineral drug-abraga Parpam. Research Journal of Pharmaceutical Biological and Chemical Sciences. 2015; 1; 6(6): 844-50.(6(6)): 844–50.
29. Pattabiraman K., Muthukumaran P. Antidiabetic and Antioxidant Activity of Morinda tinctoria roxb Fruits Extract in Streptozotocin-Induced Diabetic Rats. Asian J. Pharm. Tech. 2011; 1(2): 34-39
30. A Choudhury, RJ Mandade, SH Patil, A Khan, PD Warke, KS Patil. Effect of Ficus glomerata Fruit Extract on Various Biochemical Parameters in Alloxan Induced Diabetic Rats. Research J. Pharmacognosy and Phytochemistry 2010; 2(1): 82-84.
31. E. Anthony, Monago, C. Comfort,Belonwu, D. Chuka. Phytochemical Screening and Acute- and Organ- Toxicity Evaluation of Telfairia occidentalis Root Aqueous Extract on Normal Wister Rats. Research J. Pharmacognosy and Phytochemistry. 2010; 2(5): 417-420.
32. J. Beula, R. Suthakaran, M. Viswaja, CH. Shankar, G. Sree Lakshmi. Anti-diabetic effect of Gymnema sylvestre an Alloxan-Induced Diabetic in Male Albino Wistar Rats. Asian Journal of Pharmacy and Technology. 2023; 13(1): 34-0.
33. Sachin R Patil, MB Patil, Ravi Kumar, Mahesh S. Paschapur. Effect of Ethanolic Extract of Borassus flabellifer L. Male Flowers (Inflorescences) on Chemically Induced Inflammation in Wistar Rats. Research J. Pharmacognosy and Phytochemistry. 2009; 1(1): 59-63.
34. Arunachalam K, Thiruthani M, Abdul Kader Jeylani MP, Rajarajeshwari A. Antidiabetic activity of Ayakaandha abraga chendhuram on streptozotocin induced diabetes in rats. Int J Curr Res Med Sci. 2017; 3(11): 1–4.
35. Sathyaseelan Thennarasan, Subbiah Murugesan, Vajiravelu Sivamurugan. Antidiabetic efficacy of Methanol extract Brown Alga Lobophora variegata on Alloxan stimulated Hyperglycemic Wistar Albino Rats. Asian J. Pharm. Tech. 2017; 7 (3): 157-165.
36. Shankar R, Singhal RK. Clinical studies of the effect of abraga (mica) chendooram in the treatment of diabetes mellitus (neerazhivu). Journal of Research in Ayurveda and Siddha. 1995; 16 (3-4): 108–17.
37. Priyan B, Prasad VM, Duraichi A. Assessment of Functional Group in Herbo-mineral Siddha Formulation Abraga Parpam through Fourier Transform Infrared Spectroscopy.