ABSTRACT:
Ovarian clear cell carcinoma (OCCC) is a distinct and relatively uncommon subtype of epithelial ovarian cancer, characterised by unique histopathological features, molecular alterations, and clinical behaviour. It is often associated with endometriosis and demonstrates relative resistance to conventional platinum-based chemotherapy. We report the case of a 60-year-old nulliparous postmenopausal woman who presented with a rapidly enlarging abdominal mass, weight loss, and pressure symptoms over three months. Imaging revealed a large right adnexal solid-cystic mass suggestive of ovarian malignancy with concomitant uterine fibroids. Tumour markers were elevated, particularly CA 125 and CA 19-9. She underwent definitive surgical management, including total abdominal hysterectomy, bilateral salpingo-oophorectomy, omentectomy, and appendicectomy. Histopathological examination confirmed ovarian clear cell carcinoma, FIGO stage IC. She subsequently commenced adjuvant chemotherapy. This case highlights the aggressive clinical presentation of OCCC in a postmenopausal woman and underscores the importance of early recognition, comprehensive surgical staging, and histopathological diagnosis. OCCC remains a therapeutic challenge due to its chemoresistant nature, necessitating ongoing research into targeted therapies.