Author(s):
Jessica Komala, Nevi Yanti, Widi Prasetia, Trimurni Abidin, Wandania Farahanny, Syarifuddin Ilyas, Atika Resti Fitri, Darwin Yunus Nasution
Email(s):
nevi.yanti@usu.ac.id
DOI:
10.52711/0974-360X.2026.00238 
Address:
Jessica Komala1, Nevi Yanti1, Widi Prasetia1, Trimurni Abidin1, Wandania Farahanny1, Syarifuddin Ilyas2, Atika Resti Fitri3, Darwin Yunus Nasution4
1Department of Dentistry Conservative, Dentistry Faculty, Universitas Sumatera Utara, Medan, Sumatera, Utara, Indonesia.
2Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Medan, Sumatera Utara, Indonesia.
3Departemen of Oral Biology, Dentistry Faculty, Universitas Sumatera Utara, Medan, Sumatera, Utara, Indonesia.
4Department of Chemical, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Medan, Sumatera Utara, Indonesia.
*Corresponding Author
Published In:
Volume - 19,
Issue - 4,
Year - 2026
ABSTRACT:
Regenerative endodontic treatment has emerged as a biological alternative for managing necrotic mature permanent teeth with closed apexes. The appropriate irrigation solution plays a critical role in releasing TGF-ß1 stored in dentin, contributing to the success of such treatments. This study evaluated the effectiveness of Carbon Quantum Dots (CQDs) derived from Sapindus rarak DC in promoting TGF-ß1 release. Irrigation solutions included NaOCl 1.5% combined with Sapindus rarak DC CQDs 4%, Sapindus rarak DC extract 12.5%, and EDTA 17%. Characterization tests, including density, viscosity, flow rate, UV analysis, and HR-TEM, confirmed the successful synthesis of Sapindus rarak DC CQDs 4%. CQDs 4% and Sapindus rarak DC extract 12.5% showed acidic pH, supporting TGF-ß1 release. Twenty-seven single-rooted premolars underwent root canal preparation using the V-Taper Gold rotary system up to size #25.08. Irrigation with NaOCl 1.5% + Sapindus rarak DC CQDs 4%, NaOCl 1.5% + Sapindus rarak DC extract 12.5%, and NaOCl 1.5% + EDTA 17% was performed, followed by ultrasonic agitation for 1 minute. The TGF-ß1 release was quantified using ELISA kits. Kruskal-Wallis analysis showed significant differences among groups (p<0.05). However, Mann-Whitney analysis revealed no significant difference between Sapindus rarak DC CQDs 4% and EDTA 17%. In conclusion, NaOCl 1.5% + Sapindus rarak DC CQDs 4% demonstrated comparable effectiveness to NaOCl 1.5% + EDTA 17% in promoting TGF-ß1 release, highlighting its potential as a biocompatible alternative in regenerative endodontic treatments.
Cite this article:
Jessica Komala, Nevi Yanti, Widi Prasetia, Trimurni Abidin, Wandania Farahanny, Syarifuddin Ilyas, Atika Resti Fitri, Darwin Yunus Nasution. Role of Carbon Quantum Dots of Sapindus Rarak DC on The Released of TGF-β1 of Matrix Dentine. Research Journal of Pharmacy and Technology. 2026;19(4):1660-6. doi: 10.52711/0974-360X.2026.00238
Cite(Electronic):
Jessica Komala, Nevi Yanti, Widi Prasetia, Trimurni Abidin, Wandania Farahanny, Syarifuddin Ilyas, Atika Resti Fitri, Darwin Yunus Nasution. Role of Carbon Quantum Dots of Sapindus Rarak DC on The Released of TGF-β1 of Matrix Dentine. Research Journal of Pharmacy and Technology. 2026;19(4):1660-6. doi: 10.52711/0974-360X.2026.00238 Available on: https://rjptonline.org/AbstractView.aspx?PID=2026-19-4-27
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