Author(s):
Simran Gangotri, Dharmendra Jain, Ishwari Choudhary
Email(s):
drishwari1204@gmail.com
DOI:
10.52711/0974-360X.2026.00166 
Address:
Simran Gangotri1, Dharmendra Jain2, Ishwari Choudhary1,2*
1Raigarh College of Pharmacy, Raigarh, C.G. India.
2Department of Pharmaceutical Sciences, Dr. H.S. Gour Central University, Sagar, (M.P.) India.
*Corresponding Author
Published In:
Volume - 19,
Issue - 3,
Year - 2026
ABSTRACT:
Vitiligo is a common skin disorder affecting approximately 4% of the global population, with limited effective treatment options. Advances in novel delivery systems have opened new avenues for improving drug penetration and therapeutic outcomes in such dermatological conditions. This study aimed to develop and evaluate a dual drug delivery system combining piperine-loaded transferosomes (TS) and psoralen-based ointment for the management of vitiligo. Transferosomes were prepared using a factorial design approach and optimized based on vesicle characteristics, entrapment efficiency, and in vitro release. The optimized piperine-loaded TS were incorporated into a psoralen-containing ointment to enhance topical delivery. The combined formulation was characterized for physicochemical parameters, diffusion behavior, antibacterial activity, and stability. Results indicated sustained drug release and good formulation stability, suggesting efficient skin permeation and therapeutic potential. The developed dual delivery system may serve as a promising approach for the effective topical management of vitiligo and associated skin infections.
Cite this article:
Simran Gangotri, Dharmendra Jain, Ishwari Choudhary. Development and Characterization of Herbal Constituents-Loaded Ointment as Dual Drug Delivery System for Vitiligo Management. Research Journal Pharmacy and Technology. 2026;19(3):1163-8. doi: 10.52711/0974-360X.2026.00166
Cite(Electronic):
Simran Gangotri, Dharmendra Jain, Ishwari Choudhary. Development and Characterization of Herbal Constituents-Loaded Ointment as Dual Drug Delivery System for Vitiligo Management. Research Journal Pharmacy and Technology. 2026;19(3):1163-8. doi: 10.52711/0974-360X.2026.00166 Available on: https://rjptonline.org/AbstractView.aspx?PID=2026-19-3-27
5. REFERENCES:
1. Zalfa A. Malek A. Jordan C. Ho T. Upadhyay PR. Fleischer A. Malek A. Jordan C. The enigma and challenges of vitiligo pathophysiology and treatment. Pigment Cell Melanoma Res. 2020; 00: 1–10.
2. Frisoli ML. Essien K. Harris JE. Vitiligo: Mechanisms of Pathogenesis and Treatment.Annu Rev Immunol. 2020; 26; 38: 621-648.
3. Castillo E. Eugenia M. Rosende G. Solis IM. The Use of Herbal Medicine in the Treatment of Vitiligo: An Updated Review Planta Med 2023; 89(5): 468-483. doi: 10.1055/a-1855-1839. Epub 2022 Nov 15.
4. Buhimschil AD. Gooden DM. ing H. Fels DR. Hansen KS. Beyer WF. Dewhirst MW. Walder H. Gasparro FP. Psoralen Derivatives with Enhanced Potency. Photochemistry and Photobiology. 2020; 1-18.
5. Muthukumar S, Noori Irfana Parvin MK, Shobana S, Vimala N, Vinesha R, Sundaraganapathy R. Formulation and Evaluation of Novel Herbal Ointment for the Treatment of Fungal Infection. Research Journal of Pharmacy and Technology. 2021; 14(3): 1459-1464. doi:10.5958/0974-360X.2021.00325.5.
6. Sahu D, Bora M, Dixit AK, Jamadagni S, Das M, Cheemalapati N, Sinha B, Alam Q, Pawar S, Vara Prasad PV. Evaluation of Safety and Efficacy of an Ayurvedic Ointment against Acute Burn Injury in Wistar Rats. Research Journal of Pharmacy and Technology. 2022; 15(3): 1201-1206. doi:10.52711/0974-360X.2022.00201.
7. Ravi Kumar, Sachin Tyagi. A Review on Natural Treatment’s of Vitiligo. Asian J. Pharm. Res. 2020; 10(4): 263-267.
8. P. Prapulla. A Review on: Vitiligo- A Non Contagious Chronic Disease different Types and Treatments. Asian J. Research Chem. 2019; 12(2): 120-125.
9. Shaikh Habeeba, Shaikh Siddiqua. Babchi unani marketed formulation effective in treatment of vitiligo: A case study. Research Journal of Pharmacognosy and Phytochemistry. 2022; 14(1): 1-4.
10. R. Vinodini, A. M. Amala Hazel, M. Meenakshi Sundaram, N. J. Muthukumar. Clinical Evaluation of Parangipattai chooranam (internal) and Annabedhi chenduram (external) for Venpulli (Vitiligo) in children. Research J. Pharm. and Tech. 2019; 12(12): 5932-5936.
11. Alokananda Chakraborty, Priyanka Pallapolu, Seelamneni Thulasamma, Lahari Kuna, Shravan Kumar Ghali, Kaiser Jamil, Ghazala Javed, Munawwar Husain Kazmi. Genetic variations in NLRP1 and Glutathione S-Transferase are associated with Generalized Vitiligo of Phlegmatic Clinical Phenotypes in Unani Medicine Philosophy of South Indian Population. Research Journal of Pharmacy and Technology. 2022; 15(5): 2221-7.
12. Bharathy K, Bhagyalakshmi B, Punitha D. Anti-vitiligo effect of Thespesia populnea L. bark against Tyrosinase enzyme using In-silico model. Research Journal of Pharmacy and Technology. 2024; 17(5): 1968-2.
13. Samir Shah, Kintu Patel, Mohsin Pathan. Evaluation of the Effect of Piperine on Bioavailability and Pharmacokinetics of Macrolides in Rats. Asian J. Res. Pharm. Sci. 2018; 8(2): 61-67.
14. Sakshi Bhardwaj, Sonal Dubey. Qsar and Docking Studies of Some Novel Piperine Analogues as Monoamine Oxidase Inhibitors. Asian Journal of Research in Pharmaceutical Sciences. 2022; 12(2): 115-2.
15. Ujjwal S. Yeotkar, Mahendra Nimbhorkar, Tushar A. Deshmukh, Vijay R. Patil. Quantitative Estimation of Piperine in Ayurvedic Formulations by HPTLC. Asian J. Research Chem. 2010; 3(4): 898-902.