Author(s): Rakam Gopi Krishna, Afshan Nausheen, Bethi Ganga Shivani, Ruthika Kingari, Konale Pallavi

Email(s): gopirakam@gmail.com

DOI: 10.52711/0974-360X.2026.00134   

Address: Rakam Gopi Krishna*, Afshan Nausheen, Bethi Ganga Shivani, Ruthika Kingari, Konale Pallavi
Department of Pharmaceutical Chemistry, Marri Laxman Reddy Institute of Pharmacy, Dundigal (V and M), Medchal (Dist), Hyderabad, Telangana, India – 500043.
*Corresponding Author

Published In:   Volume - 19,      Issue - 2,     Year - 2026


ABSTRACT:
As awareness of health issues has grown, natural antioxidants are becoming more and more popular. These substances are in charge of preventing autoxidation processes in the food chain and lowering oxidative stress in the human body. Free radicals have been linked to a number of illnesses, such as cancer, diabetes, aging, and arthritis. Antioxidant treatment has become increasingly important in the treatment of diseases. The effects of antioxidants can be incalculable; they can boost the protective catalytic capacities of cells or hinder the organization of ROS or remove free radicals. Antioxidants N-acetylcysteine and vitamin C are effective in reducing diabetes entanglements, suggesting that both dietary supplements and the consumption of ordinary cell reinforcements may be beneficial. Numerous plants' antioxidant activity has attracted a lot of interest because of its possible health advantages in minimizing the risk of chronic diseases and avoiding oxidative stress. This study shows antioxidant properties of different plant extracts, focusing on their phenolic and flavonoid content, as well as their ability to scavenge free radicals. The current review indicates that plants like turmeric, neem, mint etc. will exhibit high antioxidant capacity, correlating with their phytochemical profiles. This emphasizes how crucial plant-based antioxidants are for proper nutrition and how they may be used therapeutically to stop oxidative damage. Crystallizing the data on antioxidant activity for different plants, synthetic chemicals, and novel medications is the goal of this review.


Cite this article:
Rakam Gopi Krishna, Afshan Nausheen, Bethi Ganga Shivani, Ruthika Kingari, Konale Pallavi. Advances in Novel Drugs, Plants and Phytoconstituents proved for Antioxidant Activity - A Comprehensive Review. Research Journal of Pharmacy and Technology. 2026;19(2):946-4. doi: 10.52711/0974-360X.2026.00134

Cite(Electronic):
Rakam Gopi Krishna, Afshan Nausheen, Bethi Ganga Shivani, Ruthika Kingari, Konale Pallavi. Advances in Novel Drugs, Plants and Phytoconstituents proved for Antioxidant Activity - A Comprehensive Review. Research Journal of Pharmacy and Technology. 2026;19(2):946-4. doi: 10.52711/0974-360X.2026.00134   Available on: https://rjptonline.org/AbstractView.aspx?PID=2026-19-2-63


REFERENCES:
1.    Rakam GK, Sundararajan R. In vitro antioxidant activity of Bougainvillea glabra and Mucuna pruriens. International Journal of Research in Pharmaceutical Sciences. 2020;11(1): 806-812.
2.    Lobo V. et al. Free Radicals, Antioxidants and Functional Foods: Impact on Human Health. Pharmacognosy Review. 2010; 4: 118-126. https://doi.org/10.4103/0973-7847.70902.
3.    Flieger J, Flieger W, Baj J, Maciejewski R. Antioxidants: Classification, Natural Sources, Activity/Capacity Measurements and Usefulness for the Synthesis of Nanoparticles. Materials (Basel). 2021; 14(15):4135. doi: 10.3390/ma14154135. 
4.    Venkata Subba Rao K, Laishram S, Tridib KG. A critical review of analytical methods for determination of curcuminoids in turmeric. The Journal of Food Science and Technology. 2019; 56(12):5153- 5166. Doi: 10.1007/s13197-019-03986-1.
5.    Tanvir EM, Sakib Hossen Md, Fuad Hossain Md, Rizwana A, Siew HG et al., Antioxidant Properties of Popular Turmeric (Curcuma longa) Varieties from Bangladesh. Journal of Food Quality. 2017; 1: 1-8. https://doi.org/10.1155/2017/8471.
6.    Showkat Ahmad B, Mohammed Iqbal Z, Shahid Ud DW, Ishfaq Mohiuddin,  Mubashir Hussain M. Invitro evaluation of Indigofera heterantha extracts for antibacterial, antifungal and anthelmintic activities. Journal of Pharmaceutical Health Care and Sciences. 2024;10.1-7. https://doi.org/10.1186/s40780-024-00328-y.
7.    Marja P, Kahkonen, Anu I, Hopia, Heikki J, et al., Antioxidant activity of plant extracts containing phenolic compounds. Journal of Agricultural and Food Chemistry. 1999; 47(10):3954-3962. https://doi.org/10.1021/jf9901461.
8.    Margalit B, Lucy V, Hugo E, Gottlieb, Shlomo G. The antioxidant activity of aqueous spinach extract: chemical identification of active fractions. 2001; 58(1): 143-152.
9.    Manjeera K, Sundararajan R. Toxicity Studies of Abutilon crispum and Indigofera prostrata Whole Plants on Wistar Rats. Tropical Journal of Natural Product Research. 2024; 8(11): 9073-8.
10.    Feng Lin S, Ren You G, Yuan Z, Qin Xiao, Lei Kuang et al., Total phenolic contents and antioxidant capacities of selected Chinese medicinal plants.  International Journal of Molecular Sciences. 2010; 11(6): 2362-2372. doi: 10.3390/ijms11062362.
11.    Sunday Joseph M, Jilmari Shadrack S, Helga Bedan I, Martha Orendu, Oche Attah. et al., Phytochemical screening and in vitro antioxidant activities of aqueous and methanol extracts of Aloe vera. 2023; 8: 100291. https://doi.org/10.1016/j.prmcm.2023.100291.
12.    Hua-Bin Li, Ka-Wing Cheng, Chi-Chun Wong, King-Wai Fan, Feng Chenab Yue Jiang. Evaluation of antioxidant capacity and total phenolic content of different fractions of selected microalgae. Food chemistry. 2007; 102:(3): 771-776.
13.    Jose Francisco I, Ezeiza Acosta b, Zuca GB, Juan Luis DG, María G, et al., An overview of Neem (Azadirachta indica) and its potential impact on health. Journal of Functional Foods. 2020; 74: 104171.
14.    Veerasamy R, Sethu Vasanthi b, Sivadasan S, Syed Adnan A, Rajak Harish. Green synthesis of silver nanoparticles using Atrocarpus altilis leaf extract and the study of their antimicrobial and antioxidant activity. Materials Letters.  2011; 180: doi:10.1016/j.matlet.2016.05.172.
15.    Manjeera K, Sundararajan R. Standardization and Phytochemical screening of Abutilon crispum. Research Journal of Pharmacy and Technology. 2024;17(4): 1621-0. doi: 10.52711/0974-360X.2024.00256
16.    Rashed Hasan Md, Mohammad Majedul H, Amirul Hoque Md, Shahin Sultana, Mohammad Mahbubur Rahman, Md. Aftab Ali Shaikh Md. Khabir Uddin S. Antioxidant activity study and GC-MS profiling of Camellia sinensis Linn. 2023; 10(1): e23514.  doi: 10.1016/j.heliyon.2023.e23514.
17.    Mohsen Soleimani, Ahmad Arzani, Vida Arzani, Thomas H, Roberts. Phenolic compounds and antimicrobial properties of mint and thyme. Journal of Herbal Medicine. 2022; 36: 100604.
18.    Snehal Praful S, Rajendra Baliram K. Qualitative and Quantitative Phytochemical Evaluation, Antioxidant and Antimicrobial activity of Hardwickia binata Roxbs. leaf extract in various solvent. Research Journal of Pharmacy and Technology. 2024; 17(11): 5267-3. doi: 10.52711/0974-360X.2024.00806 
19.    Liza G. Riachi A, Carlos AB. De Maria A. Peppermint antioxidants revisited. Food Chemistry. 2015; 176(1): 72-81.
20.    Ehiobu JM, Idamokorob ME, Afolayana AJ. Phytochemical content and antioxidant potential of leaf extracts of Citrus Limon (L.) Osbeck collected in the Eastern Cape Province, South Africa. South African Journal of Botany. 2021; 141: 480-6.
21.    Sonia R, Savithri S, Sangeetha R, Shridevi G. Invitro antimicrobial activity of Mtad Photoactivated Disinfection along with Chlorohexidine on Enterococcus feacalis, Staphylococcus aureus and candida albicans. Research Journal of Pharmacy and Technology. 2024; 17(8): 3752-6. doi: 10.52711/0974-360X.2024.00583 
22.    Chevidaev VV, Bokov DO, Malinkin AD, Makarenko MA, Bessonov VV, et al., Volatile compounds and fatty acids of mixture herbal product Pectorales Species No 2. Research Journal of Pharmacy and Technology. 2024; 17(11): 5412-6. doi: 10.52711/0974-360X.2024.00827 
23.    Jun Yu, Limin W, Rosemary LW, Edward GM, Leonard MP. Antioxidant activity of citrus limonoids, flavonoids, and coumarins. Journal of Agricultural and Food Chemistry. 2005; 53(6): 2009-14. doi: 10.1021/jf0484632.
24.    Helle W, Anne BS, Karl EM. Antioxidant activity in extracts from coriander. Food Chemistry. 2004; 88(2): 293-297.
25.    Rakam Gopi Krishna, M. Srinivasa Murthy, V. Kavya. Method development and validation of RP-HPLC method for the determination of sumatriptan in bulk and pharmaceutical dosage form. Research Journal of Pharmacy and Technology. 2021; 14(11): 5856-2. doi: 10.52711/0974-360X.2021.01019
26.    Rakam Gopi Krishna and Raja Sundararajan. Myocardial Protective Impact of Mucuna pruriens on Isoproterenol Prompted Myocardial Necrosis.  Scholars Research Library, Der Pharmacia Lettre, 2018; 10(3): 37-56.
27.    Kamel M, Mariem BJ, Nidhal S, Olfa B, Jazio S, et al., Antioxidant activity of methanolic extracts from three coriander (Coriandrum sativum L.) fruit. Arabian Journal of Chemistry. 2017; 10(2): 784-6.
28.    Safie Z, Aoumeur B. Essential oil composition of Coriandrum sativum seed cultivated in Algeria as food grains protectant. Food Chemistry. 2010; 122(4): 1726-8.
29.    Krishna RG, Sundararajan R. Screening of antioxidant activity of Mucuna pruriens by in vivo model. International Journal of Research in Pharmaceutical Sciences. 2019; 10(1): 523-530.
30.    Klancnik A, Guzej B, Kolar MH, Abramovic H, Mozina SS. In vitro antimicrobial and antioxidant activity of commercial rosemary extract formulations. Food Protection. 2009; 72(8): 1744-1752. doi: 10.4315/0362-028x-72.8.1744.
31.    Beretta G, Artali R, Facino RM, Gelmini F. An analytical and theoretical approach for the profiling of the antioxidant activity of essential oils: the case of Rosmarinus officinalis L. Journal of Pharmaceutical and Biomedical Analysis. 2011; 55(5): 1255-1264. doi: 10.1016/j.jpba.2011.03.026. 
32.    Bozin B, Mimica DN, Samojlik I, Jovin E. Antimicrobial and Antioxidant properties of Rosemary at rosemary essen and Sage (Rosmarinus officinalis L. and Salvia officinalis L., Laminaceae) essential oils. Journal of Agricultural and Food Chemistry. 2007; 55: 7879-7885. doi: 10.1021/jf0715323. 
33.    Tai J, Cheung S, Wu M, Hasman D. Antiproliferation effect of Rosemary (Rosmarinus officinalis) on (24) reported that rosemary human ovarian cancer cells in vitro. Phytomedicine. 2012:19:436-443. doi: 10.1016/j.phymed.2011.12.012.
34.    Adrian L. Lopresti, Stephen, Smith SA, Alexandra P. Effects of a Bacopa monnieri extract (Bacognize) on stress, fatigue, quality of life and sleep in adults with self-reported poor sleep: A randomised, double-blind, placebo-controlled study. Journal of Functional Foods. 2021; 85: 104671.
35.    Massinissa Yahia, Mouloud Yahia, Afaf Benhouda. Antitumor Activity of Methanolic Fractions Extracted from the Aerial Part of Algerian Hyoscyamus albus and apoptotic cell Aspect Visualization. Research Journal of Pharmacy and Technology. 2017; 10(11): 3676-3680. doi: 10.5958/0974-360X.2017.00666.7 
36.    Fiona CR,  Anil Kumar NV, Goutam Thakur . The potency of heterocyclic curcumin analogues: An evidence-based review. Pharmacological Research.  2021; 166(3):105489. doi: 10.1016/j.phrs.
37.    Rakam Gopi Krishna and Raja Sundararajan. Cardioprotective and antioxidant effects of Bougainvillea glabra against isoproterenol induced myocardial necrosis in albino rats. International Journal of Phytomedicine. 2018; 10 (1): 45-57. 
38.    Rakam Gopi Krishna, Raja Sundararajan. Invivo Antioxidant Activity of Bougainvillea glabra. IOSR Journal of Pharmacy. 2018; 8(6): 11-18.
39.    Mathew J, Arora KM, Mazumdar A, Kumar G, Karthik L, Bhaskara Rao KV. Evaluation of phytochemical composition and antioxidant activity of aqueous extract of Barleria mysorensis and Furcraea foetida leaves, Research Journal of Pharmacy and Technology. 2012; 5(12): 1503-1508. 
40.    Pierachille S, Juan CS, Fiammetta D, Giada L, Marina S, et al., Anti-Inflammatory and Anti-Oxidant Properties of N-Acetylcysteine: A Fresh Perspective. Journal of Clinical Medicine. 2024, 13(14), 4127; https://doi.org/10.3390/jcm13144127.
41.    Anatoly Z. N-Acetylcysteine: Antioxidant, Aldehyde Scavenger. Chemical Research in Toxicology. 2019; 32(7): 1318-1319. doi: 10.1021/acs.chemrestox.9b00152.
42.    Sara Chadi, Sabah Boumerfeg, Abderrahmane Baghiani, Thoraya Guemmez, Amel Boudechicha. Polyphenol content, Antioxidant and Antimicrobial activities of Hyoscyamus albus L. Aerial extracts. Research Journal of Pharmacy and Technology. 2024; 17(11): 5515-4. doi: 10.52711/0974-360X.2024.00843 
43.    Farhath FA, Shariq S, Mohammed Irfhan N, Zaheer Ahmed N, Jaculin R, Mageswari S, Noman Anwar. Pharmacognostical Standardization, Phytochemical Evaluation and Contaminants Determination of Ustukhuddūs (Lavandula stoechas Linn)- A Potent Unani Drug. Research Journal of Pharmacy and Technology. 2024; 17(11): 5499-8. doi: 10.52711/0974-360X.2024.00841 
44.    Marina V, Hector GC, Erica L, Maria R. Mitochondria-targeted antioxidant mitoquinone deactivates human and rat hepatic stellate cells and reduces portal hypertension in cirrhotic rats. Liver International. 2017; 37(7): 1002-1012. doi: 10.1111/liv.13436. 
45.    Rakam Gopi Krishna, N. Vinuthna, T. Sushmitha, V. Mounika, T. Manikanta. Extraction, Preliminary Phytochemical Screening and Antibacterial Activity of Terminalia chebula Fruit. International Journal of Allied Medical Sciences and Clinical Research. 2024; 12(3): 285-292.
46.    Keller JN, Kindy MS, Holtsberg FW, St Clair, Germeyer A, et al., Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction. Journal of Neuroscience. 1998; 18(2): 687-97. doi: 10.1523/JNEUROSCI.18-02-00687.1998.
47.    Rakam Gopi Krishna and Raja S. Molecular Docking Study of Isolated Phytoconstituents from Bougainvillea glabra and Mucuna pruriens. European Journal of Biomedical and Pharmaceutical sciences. 2018; 5(11): 386-394.
48.    Rakam Gopi Krishna and Raja Sundararajan. A complete evaluation on Bougainvillea glabra: Ethnomedical information, Active constituents and Pharmacological actions. American Journal of Pharm Tech Research. 2017; 7(1): 299-307.
49.    Marco T, Alessandra C, Monika S, Cristiana B, Paola F, et al., Silybin, a component of sylimarin, exerts anti-inflammatory and anti-fibrogenic effects on human hepatic stellate cells. Journal of Hepatology. 2009; 50(6): 1102-11. doi: 10.1016/j.jhep.2009.02.023. 
50.    Estevao MS, Carvalho LC, Ferreira LM, Fernandes E, Marques MMB.  2011.  Analysis of the antioxidant activity of an indole library: cyclic voltammetry versus ROS scavenging activity. Tetrahedron Letters. 52:101-106.
51.    Yogesh S. Medicinal Plants as Source of Antiemetic Agents: A Review. Asian Journal of Pharmacy and Technology. 2011; 1(2): 25-27.
52.    Meena AK, Rao MM, Meena RP, Panda P, Renu. Pharmacological and Phytochemical Evidences for the Plants of Wedelia Genus- A Review. Asian Journal of Pharmaceutical Research. 2011;1(1): 07-12.
53.    Mohanty PK, Neha Chourasia, Neraj Kumar B, Jaliwala YA. Preliminary Phytochemical Screening of Cajanus cajan Linn. Asian Journal of Pharmacy and Technology. 2011; 1(2): 49-52.
54.    Ram Kumar S, Harideep Singh, Amit Roy. Antioxidative characteristics of ethanol and aqueous extracts of Curcuma amada rhizomes. Research Journal of Pharmacognosy and Phytochemistry 2009; 1(1): 41-43.
55.    Swati R, Akhilesh G. Development and Study of Wound Healing Activity of an Ayurvedic Formulation. Asian Journal of Research in Pharmaceutical Sciences. 2011; 1(1): 26-28.
56.    S.G. Killedar, K.I. Kope, S.B. Sangle , M.S. Tamboli. Standardization and Antimicrobial Activity of Watery Fluid at Floral Base of Spathodea campanulata (Pal). Asian Journal of Pharmaceutical Analysis. 2011; 1(1): 19-21.
57.    Nikhat F, Satynarayanaa D, Arun B Joshia. Phytochemical and Pharmacological Investigation of Roots of Syzygium Cuminii (L) Skeel. Asian Journal of Research in Chemistry. 2008; 1(1): 22-25.
58.    Kashnia AR, KL Senthilkumar, T Karthiyayini, K Senthilkumar. Anti-Hyperlipidemic Activity of Ethanolic and Aqueous Extracts of Flowers of Nymphaea nouchali (Burm.) F. Research Journal of Pharmacology and Pharmacodynamics. 2009; 1(1):13-15.
59.    Maru A, Pattamatta U, Patravale VB. Sunflower wax as a New Natural Cosmetic Raw Material: Purification and Application in Lipsticks. Research Journal of Pharmaceutical Dosage Forms and Technology. 2009; 1(1):45-48.
60.    Takao, T, Kitatani F, Watanabe N, Yagi A, Sakata K. A simple screening method for antioxidants and isolation of several antioxidants produced by marine bacteria from fish and shellfish. Bioscience, Biotechnology and Biochemistry, 1994; 58: 1780-1783. https://doi.org/10.1271/bbb.58.1780.
61.    Rakam Gopi Krishna and Raja Sundararajan. Toxicity studies of Bougainvillea glabra and Mucuna pruriens. International Journal of Pharmaceutical Sciences and Research. 2020; 11(10): 1000-1008. 
62.    Itzhanova KhI, Remetova NS, Zakareyeva AK, Abdrakhmanova GM, Murzaliyeva GT. Technology of Application Dosage Form with Extract of Xanthium strumarium L. for use in Dental Practice. Research Journal of Pharmacy and Technology. 2024; 17(11):5561-6. doi: 10.52711/0974-360X.2024.00849 
63.    Shalini Y, Sunil S, Bir Singh Y, Rohtash I. The Impact of Medication Compliance on mild Cognitive Impairment in Hypertensive Individuals: A Cohort Study. Research Journal of Pharmacy and Technology. 2024; 17(11): 5201-6. doi: 10.52711/0974-360X.2024.00796

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.52711/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank

Journal Policies & Information


Recent Articles




Tags


Not Available