Author(s):
Sonali Sahoo, Smriti Dewangan, Debasmita Dubey, Pratap Kumar Sahu, Durga Madhab Kar, Jyotirmaya Sahoo, Rakesh Tiwle, Shakti Ketan Prusty
Email(s):
shaktiketanprusty@soa.ac.in
DOI:
10.52711/0974-360X.2026.00122 
Address:
Sonali Sahoo1, Smriti Dewangan2, Debasmita Dubey3, Pratap Kumar Sahu1, Durga Madhab Kar1, Jyotirmaya Sahoo4, Rakesh Tiwle5, Shakti Ketan Prusty1*
1School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India, 751003.
2Amity Institute of Pharmacy, Amity University Chhattisgarh Chhattisgarh, Raipur, Chhattisgarh.
3Medical Research Laboratory, IMS and Sum Hospital, Bhubaneswar, Odisha, India, 751003.
4School of Pharmacy, ARKA JAIN University, Jamshedpur, Jharkhand, India, 832108.
5Gondia college of Pharmacy, Chlood, Road, Gondia 441601, Maharashtra.
*Corresponding Author
Published In:
Volume - 19,
Issue - 2,
Year - 2026
ABSTRACT:
A growing body of research links diabetes to cognitive decline and Alzheimer’s disease (AD), possibly through mutual pathological mechanisms. This study explores the role of gut microbiota, specifically the probiotic Lacticaseibacillus casei (L. casei), in diabetes-induced AD (DI-AD). Using a rat model injected with streptozotocin (STZ), we assessed the effects of L. casei, donepezil (DNP), and their combination over a 21-day period. L. casei significantly improved cognitive function in behavioural tests, increased antioxidant enzyme (SOD) levels, and reduced oxidative stress marker (MDA) levels. RT-PCR analysis showed enhanced beneficial gut bacteria and reduced E. coli, indicating improved gut health. Additionally, L. casei treatment lowered amyloid-ß levels and reduced neurodegeneration in both gut and hippocampal tissues. These results suggest that L. casei, especially when combined with DNP, may protect against DI-AD by modulating gut microbiota and reducing neuroinflammation and amyloid pathology, offering a promising therapeutic approach.
Cite this article:
Sonali Sahoo, Smriti Dewangan, Debasmita Dubey, Pratap Kumar Sahu, Durga Madhab Kar, Jyotirmaya Sahoo, Rakesh Tiwle, Shakti Ketan Prusty. The Modulation of Gut Microbiota via Lacticaseibacillus casei Mitigates the Alzheimer's Disease Induced by Streptozotocin: An Animal Model. Research Journal of Pharmacy and Technology. 2026;19(2):859-6. doi: 10.52711/0974-360X.2026.00122
Cite(Electronic):
Sonali Sahoo, Smriti Dewangan, Debasmita Dubey, Pratap Kumar Sahu, Durga Madhab Kar, Jyotirmaya Sahoo, Rakesh Tiwle, Shakti Ketan Prusty. The Modulation of Gut Microbiota via Lacticaseibacillus casei Mitigates the Alzheimer's Disease Induced by Streptozotocin: An Animal Model. Research Journal of Pharmacy and Technology. 2026;19(2):859-6. doi: 10.52711/0974-360X.2026.00122 Available on: https://rjptonline.org/AbstractView.aspx?PID=2026-19-2-51
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