Author(s):
Anju Das, Geetha K M
Email(s):
anju1989das@gmail.com
DOI:
10.52711/0974-360X.2026.00121 
Address:
Anju Das1*, Geetha K M2
1Royal School of Pharmacy, The Assam Royal Global University, Guwahati, Assam-781035, India.
2Department of Pharmacology, College of Pharmaceutical Sciences, Dayananda Sagar University, Shavige Malleshwara Hills, Kumaraswamy Layout, Bengaluru, Karnataka, 560078, India.
*Corresponding Author
Published In:
Volume - 19,
Issue - 2,
Year - 2026
ABSTRACT:
Purpose: To evaluate anti-diabetic effects of phytoconstituents isolated from L. ciliata by using STZ-induced invivo diabetic model. Methods: Type 2 diabetes was induced in rats via intraperitoneal streptozotocin and nicotinamide (65–110mg/kg). Group 1(normal control) received 0.2% CMC (5mL/kg), Group 2 (diabetic control), Group 3 (diabetic) received exenatide (4µg/kg), while Groups 4 and 5 (diabetic) were treated with LCF-1(10 and 20mg/kg) respectively for 14 days. Blood glucose, GLP-1, DPP-4 inhibition, beta-cell regeneration, and GLUT-2/GLUT-4 gene expression were assessed. Results: In Group 2, body weight significantly decreased compared to Group 1. On the 14th day, blood glucose levels significantly decreased in the exenatide and LCF-1 treated groups compared to Group 2(p<0.01), indicating their anti-diabetic properties. LCF-1 exhibited a notable increase in GLP-1 secretion (p<0.001) and plasma insulin levels (p<0.05) compared to Group 1 and Group 3, suggesting its antidiabetic effect, partly via GLP-1 secretion promotion. Additionally, LCF-1 treatment led to significant increases in GLP-1 secretion (p<0.001), DPP-4 inhibition (p<0.05), serum insulin levels (p<0.05), and beta-cell regeneration. The LCF-1 treatment notably upregulated glucose transport gene expression compared to both untreated and control groups, indicating a potential enhancement in glucose uptake mechanisms. Conclusion: Our study concludes that LCF 1 act as a potent antidiabetic agent by stimulating pancreatic insulin release, increasing GLP-1 levels, DPP-4 inhibition, promoting beta cell regeneration and glucose transport gene expression in STZ induced diabetic model.
Cite this article:
Anju Das, Geetha K M. Lindernia ciliata Exhibits Anti-Diabetic effects in Streptozotocin-Induced Diabetic Model by Upregulation of GLUT-2 and GLUT-4 Gene Expression. Research Journal of Pharmacy and Technology. 2026;19(2):851-8. doi: 10.52711/0974-360X.2026.00121
Cite(Electronic):
Anju Das, Geetha K M. Lindernia ciliata Exhibits Anti-Diabetic effects in Streptozotocin-Induced Diabetic Model by Upregulation of GLUT-2 and GLUT-4 Gene Expression. Research Journal of Pharmacy and Technology. 2026;19(2):851-8. doi: 10.52711/0974-360X.2026.00121 Available on: https://rjptonline.org/AbstractView.aspx?PID=2026-19-2-50
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