Author(s):
Amita G. Dhadphale, Kamini J. Donde
Email(s):
kaminidonde@ruiacollege.edu
DOI:
10.52711/0974-360X.2026.00094 
Address:
Amita G. Dhadphale, Kamini J. Donde
Department of Chemistry, Ramnarain Ruia, Autonomus College, L. N. Road, Matunga (East), Mumbai - 400019, India.
*Corresponding Author
Published In:
Volume - 19,
Issue - 2,
Year - 2026
ABSTRACT:
This study investigates the potential of binary mixtures of gliclazide (GCL) and Vitamin C i.e. ascorbic acid (ASC) in various molar ratios to address the minimal aqueous solubility and dissolution characteristics of GCL. The results reveal that GCL and ASC form a eutectic mixture, at a 1:1 molar ratio exhibiting the eutectic melting temperature (TEut) at 148.60°C, as determined through phase diagram construction employing differential scanning calorimetry (DSC) and thermo-microscopy. The presence of eutectic formation was confirmed by powder X-ray diffraction (PXRD) and furrier transform infrared (FTIR) spectroscopy indicating the absence of molecular interaction within the two components in the solid state. GCL-ASC eutectic mixture significantly enhanced the solubility, wettability, and dissolution rate of GCL, with ASC serving as a water-soluble carrier. Furthermore, in the presence of excipients, the GCL-ASC mixture exhibited a superior dissolution rate compared to pure GCL. These findings underscore the potential of eutectic mixtures as a promising strategy for improving the solubility and dissolution performance of poorly water-soluble drugs like gliclazide, highlighting the importance of this work in advancing pharmaceutical formulation and bioavailability enhancement.
Cite this article:
Amita G. Dhadphale, Kamini J. Donde. Preparation and Characterization of Gliclazide - Vitamin C Eutectic Mixture for Improved Dissolution Rate. Research Journal of Pharmacy and Technology. 2026;19(2):643-0. doi: 10.52711/0974-360X.2026.00094
Cite(Electronic):
Amita G. Dhadphale, Kamini J. Donde. Preparation and Characterization of Gliclazide - Vitamin C Eutectic Mixture for Improved Dissolution Rate. Research Journal of Pharmacy and Technology. 2026;19(2):643-0. doi: 10.52711/0974-360X.2026.00094 Available on: https://rjptonline.org/AbstractView.aspx?PID=2026-19-2-23
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