Author(s):
Lilit Arshakyan, Vardan Karyan, Andranik Davinyan, Armenuhi Mnatsakanyan, Elmira Avanesova, Anahit Poghosyan, Sona Buloyan, Hrachik Gasparyan
Email(s):
sonabuloyan@gmail.com
DOI:
10.52711/0974-360X.2026.00092 
Address:
Lilit Arshakyan1, Vardan Karyan2, Andranik Davinyan1, Armenuhi Mnatsakanyan1, Elmira Avanesova1, Anahit Poghosyan1, Sona Buloyan1,3*, Hrachik Gasparyan1,3
1Scientific Technological Center of Organic and Pharmaceutical Chemistry, National Academy of Sciences of the Republic of Armenia, Yerevan, Armenia.
2Hydrometeorology and Monitoring Center, SNCO Ministry of Environment of the Republic of Armenia
3Haybusak University of Yerevan, Armenia.
*Corresponding Author
Published In:
Volume - 19,
Issue - 2,
Year - 2026
ABSTRACT:
Flavonoids are the most prevalent and widely distributed phenolic compounds found in plants demonstrating a variety of biological and pharmacological effects. They are the primary constituents of Helichrysi flos, a popular herbal remedy in indigenous medicine used as a hepatoprotective, choleretic, diuretic, spasmolytic and detoxifying agent. Among the least studied is Helichrysum rubicundum, which is widely distributed in the flora of Armenia. This study aims to investigate Helichrysum rubicundum (C. Koch.) to determine its flavonoid content and assess the hepatoprotective properties of its extract (referred to as FLR) by evaluating its impact on the liver cirrhosis. To determine the flavonoid composition of Helichrysum rubicundum (C. Koch.), we used an UHPLC ESI-QToF system. The hepatoprotective properties of the FLR were evaluated by analyzing its effects on the histological structure of the liver in an animal model of toxic cirrhosis. According to our research, the dried extract of Helichrysum rubicundum contains almost all types of flavonoids. FLR demonstrated hepatoprotective properties by counteracting pathological changes induced by CCl4. Treatment with FLR preserved the lobular architecture of the liver, with only mild fibrosis and limited inflammatory foci around the portal tracts. Helichrysum rubicundum (C.Koch.) specie of genus Helichrysum exhibits anti-inflammatory, antifibrotic and strong hepatoprotective properties due to its rich flavonoid composition. These findings suggest its potential as a raw material for developing of new hepatoprotective agents, warranting further in-depth and comprehensive studies.
Cite this article:
Lilit Arshakyan, Vardan Karyan, Andranik Davinyan, Armenuhi Mnatsakanyan, Elmira Avanesova, Anahit Poghosyan, Sona Buloyan, Hrachik Gasparyan. Determination of Flavonoids Extracted from Helichrysum rubicundum and Evaluation of their Hepatoprotective properties in Toxic Liver Cirrhosis. Research Journal of Pharmacy and Technology. 2026;19(2):631-7. doi: 10.52711/0974-360X.2026.00092
Cite(Electronic):
Lilit Arshakyan, Vardan Karyan, Andranik Davinyan, Armenuhi Mnatsakanyan, Elmira Avanesova, Anahit Poghosyan, Sona Buloyan, Hrachik Gasparyan. Determination of Flavonoids Extracted from Helichrysum rubicundum and Evaluation of their Hepatoprotective properties in Toxic Liver Cirrhosis. Research Journal of Pharmacy and Technology. 2026;19(2):631-7. doi: 10.52711/0974-360X.2026.00092 Available on: https://rjptonline.org/AbstractView.aspx?PID=2026-19-2-21
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