ABSTRACT:
Fluconazole is an antifungal medication that exhibits limited solubility and might cause severe adverse effects when used orally. An endeavour was undertaken to enhance solubility by the utilisation of the solid dispersion technique. Six formulations were created utilising the solvent evaporation method, with ß-cyclodextrin and Polyvinyl pyrollidone (PVP) serving as carriers. The water solubility, and in-vitro release characteristics of all solid dispersions were assessed and compared. The optimised formulation (F-2) was subsequently added to aloevera gel. The prepared gel was assessed for several parameters including percentage yield, assay, pH, viscosity, spreadability, extrudability, release, in-vitro kinetics, and stability studies. The gel formulation was determined to have a pH of 6.1. The viscosity was measured to be 5882.82 centipoise (cp) and exhibited favourable spreadability and extrudability. The drug content of the optimal formulation reached 96.31%, accompanied by a drug release rate of 96.5%. Therefore, including a complex into a gel can be a promising approach to enhance the solubility and effectiveness of a poorly water-soluble medication, while also boosting its antifungal action.
Cite this article:
Nidhi Jain, Babita Kumar. Formulation and Development of Aloevera Gel containing Solid Dispersion of Fluconazole. Research Journal of Pharmacy and Technology. 2026;19(2):555-0. doi: 10.52711/0974-360X.2026.00081
Cite(Electronic):
Nidhi Jain, Babita Kumar. Formulation and Development of Aloevera Gel containing Solid Dispersion of Fluconazole. Research Journal of Pharmacy and Technology. 2026;19(2):555-0. doi: 10.52711/0974-360X.2026.00081 Available on: https://rjptonline.org/AbstractView.aspx?PID=2026-19-2-10
REFERENCES:
1. Neeran Obied Jasim, Mohammed Mudhafar Habeeb Alkhuzaie. Fungal Infections (FI) Associated with Covid-19. Research Journal of Pharmacy and Technology. 2023; 16(2): 698-2. doi: 10.52711/0974-360X.2023.00119
2. Rohit Divya, Inderbir Singh, Upendra Nagaich. Characterisation and Evaluation of prepared Fluconazole Nanogel for Treating Seborrheic Dermatitis. Research Journal of Pharmacy and Technology 2023; 16(6): 2880-4. doi: 10.52711/0974-360X.2023.00474
3. Nidhi Sharma, Sudhanshu Sanadhya, Ramesh Nagarajappa, Gayathri Ramesh, Debasruti Naik. Antifungal activity of Propolis, Fluconazole and Chlorhexidine against Oral Candida albicans – A Comparative in-vitro Study. Research Journal of Pharmacy and Technology. 2022; 15(8): 3589-4. doi: 10.52711/0974-360X.2022.00601
4. Reddy MKK, Narasimha Rao B, Ravindra Reddy K. Study on Effect of Excipients in Enhancing the Solubility of Nateglinide by Solid Dispersions . Asian Journal of Pharmaceutical Research. 2012; 2(4): 144-147.
5. Divya B., Sabitha P., Ravindra Reddy, M. Kranthi Kumar Reddy , B.Narasimha Rao. An Approach to Enhance Solubility of Gatifloxacin by Solid Dispersion Technique. Asian Journal of Research in Pharmaceutical Sciences 2012; 2(2): 58-61.
6. Sonam Shukla, Swarnakshi Upadhyay, Rajneesh Kumar Gupta. Formulation and Evaluation of Griseofulvin Solid Dispersion incorporated gel for topical application. Research Journal of Pharmacy and Technology. 2022; 15(10): 4389-4. doi: Solid dispersion, Griseofulvin, Gel, Melting method, Franz diffusion cell, Solubility.
7. Pham DTT, Tran PHL, Tran TTD. Development of solid dispersion lipid nanoparticles for improving skin delivery. Saudi Pharmaceutical Journal. 2019; 27: 1019-1024. DOI: 10.1016/j.jsps.2019.08.004
8. Ashok A. Hajare, Prabhakar R. Jadhav. Improvement of Solubility and Dissolution Rate of Indomethacin by Solid Dispersion in Polyvinyl Pyrrolidone K30 and Poloxomer 188. Asian Journal of Pharmacy and Technology. 2012; 2(3): 116-122.
9. Debnath S, Kumar GV, Satyanarayana SV. Preparation and Evaluation of Solid Dispersion of Terbinafine Hydrochloride. Asian Journal of Pharmacy and Technology. 2013; 3(1): 09-15.
10. Arun Raj R, Jose E, Harindran J, Sreerekha S. Formulation and evaluation of ketoprofen solid dispersion incorporated topical gels. European Journal of Biomedical and Pharmaceutical Sciences. 2016; 3(1): 156-164.
11. Suvidha Suryakant Patil, Shriniwas Krishna Mohite. Development and Evaluation of Solid Dispersion Incorporated Topical Gel of Nabumetone. Research J. Pharm. and Tech. 2014; 7(12): 1413-1419.
12. Ahmad A. E. Alezzy, Eman B. H. Al-Khedairy. Preparation and Evaluation of Aceclofenac Solid Dispersion by Fusion Technique and Effervescent Assisted Fusion Technique: Comparative Study. Research Journal of Pharmacy and Technology. 2023; 16(11): 5358-5. doi: 10.52711/0974-360X.2023.00868
13. Vinod LG, Vishal DY, Rakesh PD. Gaikwad, L. et al. “Effect of Carbopol 934 and 940 on Fluconazole Release from Topical Gel Formulation: A Factorial Approach. Int J Curr Pharm Res. 2012; 2; 487- 93. doi:10.33786/JCPR.2012.V02I02.004.
14. Ranim Alrouhayyah, Tatiana F. Sheshko, Svetlana N. Suslina, Omran Aisha. Solid Dispersions: An Effective Technology for Improving Dissolution Kinetics of Poorly Soluble Drugs. Research Journal of Pharmacy and Technology. 2023; 16(12): 5701-6. doi: 10.52711/0974-360X.2023.00922.
15. Samal HB et al Solubility and dissolution improvement of Aceclofenac using Β-Cyclodextrin. International Journal of Drug Development & Research. 2012; 4(4): 326-333.
16. Vimalson DC et al. Techniques to enhance solubility of hydrophobic drugs: an overview. Asian Journal of Pharmaceutics. 2016; 10(2): 67-75. https://doi.org/10.22377/ajp.v10i2.625
17. Deevan Paul A et al Formulation design for poorly water-soluble drug by using solid dispersion of telmisartan for solubility and dissolution rate enhancement. Global Journal of Pharmacy and Pharmaceutical SCIENCES. 2019; 7(4): 555716. https://dx.doi.org/10.19080/GJPPS.2019.06.555716
18. Paarakh M. P., Jose P. A., Setty C & Peter christoper G. (2023). Release Kinetics – Concepts and Applications. International Journal of Pharmacy Research & Technology (IJPRT), 8(1), 12–20. https://doi.org/10.31838/ijprt/08.01.02.
19. Tekko IA. Polyethylene glycol-based solid dispersions to enhance eprosartanmesylate dissolution and bioavailability. Archives of Pharmacy & Pharmacology Research. 2019; 2(3): 1-11. DOI: 10.33552/APPR.2019.02.000537
20. Patel VP et al. Optimization of amorphous solid dispersion techniques to enhance solubility of febuxostat. Folia Medica (Plovdiv). 2021; 63(4): 557–568. https://doi.org/10.3897/folmed.63.e55838