Author(s):
Amol A. Shirsath, Aparna V. Bhalerao, Sagar B. Wankhede
Email(s):
aas.sphs@jspmuni.ac.in
DOI:
10.52711/0974-360X.2026.00692 
Address:
Amol A. Shirsath*, Aparna V. Bhalerao, Sagar B. Wankhede
JSPM University, School of Pharmaceutical Sciences, Wagholi, Pune 412207, Maharashtra, India.
*Corresponding Author
Published In:
Volume - 19,
Issue - 10,
Year - 2026
ABSTRACT:
Many therapeutic drugs, especially those that require long-term administration, high doses, or are linked to dose-dependent toxicity and high cost, will continue to have poor oral bioavailability as a significant barrier to their effective treatment. Therapeutic plasma concentrations will continue to be limited by factors such low aqueous solubility, poor dissolution, limited intestinal permeability, significant first-pass metabolism, and gastrointestinal degradation. Bioenhancers—pharmacologically inert compounds that improve the absorption and systemic availability of co-administered medications—will become more crucial in order to address these issues. The safety, affordability, and variety of modes of action of herbal bioenhancers, which are primarily derived from plant sources, will provide substantial benefits. By altering gastrointestinal physiology, blocking drug-metabolizing enzymes and efflux transporters, and enhancing membrane permeability and drug–target interactions, these medicines will increase bioavailability. Bioenhancers such as piperine, ginger, niaziridin, allicin, quercetin, genistein, glycyrrhizin, and lysergol will demonstrate substantial improvement in the pharmacokinetic and therapeutic profiles of several drugs. Integration of herbal bioenhancers into novel drug delivery systems will further enhance efficacy, reduce dosage requirements, and improve patient compliance, supporting their growing role in modern pharmaceutical development.
Cite this article:
Amol A. Shirsath, Aparna V. Bhalerao, Sagar B. Wankhede. Herbal Bioenhancers: Novel Tools for Bioavailability Enhancement. Research Journal Pharmacy and Technology. 2026;19(10):4971-7. doi: 10.52711/0974-360X.2026.00692
Cite(Electronic):
Amol A. Shirsath, Aparna V. Bhalerao, Sagar B. Wankhede. Herbal Bioenhancers: Novel Tools for Bioavailability Enhancement. Research Journal Pharmacy and Technology. 2026;19(10):4971-7. doi: 10.52711/0974-360X.2026.00692 Available on: https://rjptonline.org/AbstractView.aspx?PID=2026-19-10-68
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