Author(s):
Shakeel Ahmed Ansari, Fatma El-Sayed Hassan, Asim Muhammed Alshanberi, Mohammed Shaikhomer, Rukhsana Satar
Email(s):
shakeel.ansari@bmc.edu.sa
DOI:
10.52711/0974-360X.2026.00691 
Address:
Shakeel Ahmed Ansari1*, Fatma El-Sayed Hassan2,3, Asim Muhammed Alshanberi2, Mohammed Shaikhomer2,4, Rukhsana Satar5
1Department of Biochemistry, General Medicine Practice Program, Batterjee Medical College, Jeddah 21442, Saudi Arabia.
2General Medicine Practice Program, Batterjee Medical College, Jeddah 21442, Saudi Arabia.
3Medical Physiology Department, Kasr Alainy, Faculty of Medicine, Cairo University, Giza 11562, Egypt.
4Department of Internal Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
5Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, India.
*Corresponding Author
Published In:
Volume - 19,
Issue - 10,
Year - 2026
ABSTRACT:
Since a-amylase is essential for the metabolism of carbohydrates, its inhibition could be a useful treatment approach for controlling hyperglycemia. The aim of this review is to analyze the biological mechanisms of a-amylase inhibitors (a-AIs) and their consequences for managing hyperglycemia. A thorough search of literature was done utilizing several databases, including Google Scholar, PubMed, and Scopus. Peer-reviewed research articles, clinical trials, and reviews written in English were included. The involved studies were discussing the origin, structure, and the impact of both natural and artificial a-AIs, emphasizing those generated by plants and microbes. The a-AIs mitigates the health risks linked to hyperglycemia by slowing down the breakdown of carbohydrates, lowering postprandial glucose surges, and therefore enhancing glycemic control. When compared to their synthetic counterparts, such as acarbose and miglitol, natural inhibitors, such as flavonoids and saponins from plants, typically have less adverse effects. Synthetic and natural a-AIs are an intriguing approach to treat hyperglycemia. Investigating a-AIs further, focusing on discovering novel a-AIs that exhibit much better effectiveness and reduced side effects, refining combination treatments, and tailoring care according to patient characteristics may result in novel approaches to hyperglycemia treatment, which would eventually benefit patients.
Cite this article:
Shakeel Ahmed Ansari, Fatma El-Sayed Hassan, Asim Muhammed Alshanberi, Mohammed Shaikhomer, Rukhsana Satar. Therapeutic Potential of α-amylase Inhibitors in Managing Hyperglycemia. Research Journal Pharmacy and Technology. 2026;19(10):4963-0. doi: 10.52711/0974-360X.2026.00691
Cite(Electronic):
Shakeel Ahmed Ansari, Fatma El-Sayed Hassan, Asim Muhammed Alshanberi, Mohammed Shaikhomer, Rukhsana Satar. Therapeutic Potential of α-amylase Inhibitors in Managing Hyperglycemia. Research Journal Pharmacy and Technology. 2026;19(10):4963-0. doi: 10.52711/0974-360X.2026.00691 Available on: https://rjptonline.org/AbstractView.aspx?PID=2026-19-10-67
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