Author(s):
Saskia L Nasroen, Dharli Syafriza, Azhari Gani, Abdillah Imron Nasution, Fitri Yunita Batubara, Nur Asmah, Viona Diansari, Basri A. Gani
Email(s):
saskiyaunjani@gmail.com
DOI:
10.52711/0974-360X.2026.00666 
Address:
Saskia L Nasroen1*, Dharli Syafriza2, Azhari Gani3, Abdillah Imron Nasution4, Fitri Yunita Batubara5, Nur Asmah6, Viona Diansari7, Basri A. Gani4
1Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Universitas Jenderal Achmad Yani Cimahi, Bandung, Indonesia.
2Department of Pediatric Dentistry, Dentistry Faculty, Universitas Syiah Kuala, Darussalam, Banda Aceh, Aceh, Indonesia.
3Department of Internal Medicine, Faculty of Medicine, Universitas Syiah Kuala and Dr. Zainal Abidin Hospital, Banda Aceh, Indonesia.
4Department of Oral Biology, Dentistry Faculty, Universitas Syiah Kuala, Darussalam, Banda Aceh, Indonesia.
5Department of Conservative Dentistry, Dentistry Faculty, Universitas Sumatera Utara, Medan, Sumatera Utara, Indonesia.
6Department of Conservative Dentistry, Dentistry Faculty, Universitas Muslim Indonesia, Makasar, Sulawesi Selatan, Indonesia.
7Department of Denta Material, Dentistry Faculty, Universitas Syiah Kuala, Darussalam, Banda Aceh, Ind
Published In:
Volume - 19,
Issue - 10,
Year - 2026
ABSTRACT:
The cleft palate is a congenital craniofacial anomaly that causes both functional and aesthetic impairments. While surgical repair remains the primary treatment, it is often complicated by delayed healing, infections, and suboptimal tissue regeneration. Recent advances in biomaterials and localized drug delivery systems have emerged as potential solutions to improve these outcomes. This scoping review aims to map recent innovations in biomaterial-based strategies and drug delivery technologies applied to cleft palate reconstruction, with a focus on regenerative and pharmacological approaches. The review followed PRISMA-ScR guidelines. Literature searches were conducted in PubMed, Scopus, and Web of Science for articles published between 2013 and 2024. Studies included the use of biomaterials, nanotechnology, and pharmacological agents in cleft palate repair. Multiple biomaterials, including collagen scaffolds, chitosan-based hydrogels, and nanocomposites, have been identified for their regenerative potential. Drug delivery systems, such as hydrogel platforms and nanoparticle carriers, enable the localized and sustained release of growth factors, antibiotics, and anti-inflammatory agents. These innovations showed promising outcomes in accelerating wound healing, reducing postoperative complications, and enhancing functional tissue integration in preclinical models. Combining advanced biomaterials with targeted drug delivery represents a promising direction for improving cleft palate reconstruction. Further research is needed to validate these approaches through well-designed preclinical and clinical studies, with a focus on translational feasibility and long-term outcomes.
Cite this article:
Saskia L Nasroen, Dharli Syafriza, Azhari Gani, Abdillah Imron Nasution, Fitri Yunita Batubara, Nur Asmah, Viona Diansari, Basri A. Gani. Biomaterial and Drug Delivery Innovations in Cleft Palate Reconstruction: A Scoping Review of Regenerative and Pharmacological Strategies. Research Journal Pharmacy and Technology. 2026;19(10):4773-1. doi: 10.52711/0974-360X.2026.00666
Cite(Electronic):
Saskia L Nasroen, Dharli Syafriza, Azhari Gani, Abdillah Imron Nasution, Fitri Yunita Batubara, Nur Asmah, Viona Diansari, Basri A. Gani. Biomaterial and Drug Delivery Innovations in Cleft Palate Reconstruction: A Scoping Review of Regenerative and Pharmacological Strategies. Research Journal Pharmacy and Technology. 2026;19(10):4773-1. doi: 10.52711/0974-360X.2026.00666 Available on: https://rjptonline.org/AbstractView.aspx?PID=2026-19-10-42
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