Author(s):
Sutopo Hadi, Armidla Nadya Kurniati, Tati Suhartati, M. Rafli Yuwan Alhilabi, Yandri Yandri
Email(s):
sutopo.hadi@fmipa.unila.ac.id
DOI:
10.52711/0974-360X.2026.00648 
Address:
Sutopo Hadi*, Armidla Nadya Kurniati, Tati Suhartati, M. Rafli Yuwan Alhilabi, Yandri Yandri
Department of Chemistry, Universitas Lampung, Bandar Lampung, 35415, Indonesia.
*Corresponding Author
Published In:
Volume - 19,
Issue - 10,
Year - 2026
ABSTRACT:
This study aims to isolate and characterize bioactive compounds from kenangkan plant (Artocarpus rigida Blume) and evaluate their potential bioactivity as natural antidiabetic and antibacterial agents. This study successfully isolated and characterized 4-methyl-piceatannol, a stilbene compound, from the branch wood of kenangkan plant (A. rigida Blume). The isolation process involved maceration with methanol solvent, followed by purification using chromatography techniques (VLC, CC, TLC), and structural characterization through UV-Vis, FT-IR, NMR, and MS spectroscopy. The purified compound was obtained as yellowish-white crystals (203 mg, m.p. 238,9oC) and identified as a new stilbene compound from the Artocarpus genus. The antidiabetic bioactivity assay revealed that this compound acts as an a-amylase enzyme inhibitor with an inhibition rate of 69.1% at a concentration of 1500ppm. Antibacterial evaluation revealed strong activity against Bacillus subtilis (inhibition zone: 12mm) and moderate activity against Pseudomonas aeruginosa (inhibition zone: 10mm) at a concentration of 0.5mg/disc. These research reinforce the potential of kenangkan plant (A. rigida Blume) as a promising natural source of bioactive compounds, supporting further exploration of local biodiversity for the development of therapeutic agents in healthcare.
Cite this article:
Sutopo Hadi, Armidla Nadya Kurniati, Tati Suhartati, M. Rafli Yuwan Alhilabi, Yandri Yandri. 4-Methyl-piceatannol, A New Stilbene Compound from the Branch Wood of Kenangkan Plant (Artocarpus rigida Blume) as a Candidate for Natural Antidiabetic and Antibacterial Agent. Research Journal Pharmacy and Technology. 2026;19(10):4658-4. doi: 10.52711/0974-360X.2026.00648
Cite(Electronic):
Sutopo Hadi, Armidla Nadya Kurniati, Tati Suhartati, M. Rafli Yuwan Alhilabi, Yandri Yandri. 4-Methyl-piceatannol, A New Stilbene Compound from the Branch Wood of Kenangkan Plant (Artocarpus rigida Blume) as a Candidate for Natural Antidiabetic and Antibacterial Agent. Research Journal Pharmacy and Technology. 2026;19(10):4658-4. doi: 10.52711/0974-360X.2026.00648 Available on: https://rjptonline.org/AbstractView.aspx?PID=2026-19-10-24
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