Author(s):
Krishna N. Mundlod, Ghanshyam B. Jadhav, Shrikant Ghodse, Amol S. Jagdale
Email(s):
knmundlod@mvpcpn.edu.in
DOI:
10.52711/0974-360X.2026.00645 
Address:
Krishna N. Mundlod1*, Ghanshyam B. Jadhav1, Shrikant Ghodse1,2, Amol S. Jagdale1
1Department of Pharmaceutical Chemistry , M.V.P’S College Of Pharmacy, Nashik 422002 Affiliated to Savitribai Phule Pune University India.
2Department of Pharmaceutical Chemistry, Principal K. M. Kundnani College of Pharmacy, Mumbai 400005 India.
*Corresponding Author
Published In:
Volume - 19,
Issue - 10,
Year - 2026
ABSTRACT:
An efficient solvent-free procedure for the preparation of 2-amino-1,3,4-thiadiazoles via the condensation of aldehydes and thiosemicarbazide in the presence of catalytic amount of phosphorus pentoxide/silica gel (P2O5/SiO2) at room temperature is described. The advantages of this method are generality, high yields and short reaction time, ease of product isolation, low cost and ecologically friendly.
Cite this article:
Krishna N. Mundlod, Ghanshyam B. Jadhav, Shrikant Ghodse, Amol S. Jagdale. Amino-1,3,4-thiadiazole Derivatives from Aldehydes Using P₂O₅/SiO₂ as a Heterogeneous Catalyst under Solvent-Free Conditions. Research Journal Pharmacy and Technology. 2026;19(10):4637-3. doi: 10.52711/0974-360X.2026.00645
Cite(Electronic):
Krishna N. Mundlod, Ghanshyam B. Jadhav, Shrikant Ghodse, Amol S. Jagdale. Amino-1,3,4-thiadiazole Derivatives from Aldehydes Using P₂O₅/SiO₂ as a Heterogeneous Catalyst under Solvent-Free Conditions. Research Journal Pharmacy and Technology. 2026;19(10):4637-3. doi: 10.52711/0974-360X.2026.00645 Available on: https://rjptonline.org/AbstractView.aspx?PID=2026-19-10-21
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