Author(s):
Ahmad Najib, Muhammad Sulaiman Zubair, Muhammad Arba, Firzan Nainu, Hasnaeni, Virsa Handayani, Rezki Amriati Syarif
Email(s):
ahmad.najib@umi.ac.id
DOI:
10.52711/0974-360X.2026.00009 
Address:
Ahmad Najib1*, Muhammad Sulaiman Zubair2, Muhammad Arba3, Firzan Nainu4, Hasnaeni5, Virsa Handayani5, Rezki Amriati Syarif5
1Magister of Pharmacy, Faculty of Pharmacy, Universitas Muslim Indonesia, Makassar, Indonesia.
2Departement Medicinal Chemistry, Faculty of Pharmacy, Universitas Taddulako, Palu, Indonesia.
3Magister of Pharmacy, Faculty of Pharmacy, Universitas Halu Oleo, Kendari, Indonesia.
4Magister of Pharmacy, Faculty of Pharmacy, Universitas Hasanuddin, Makassar, Indonesia.
5Departement of Pharmacognosy-Phytochemistry, Faculty of Pharmacy, Universitas Muslim Indonesia, Makassar, Indonesia.
*Corresponding Author
Published In:
Volume - 19,
Issue - 1,
Year - 2026
ABSTRACT:
The research involved the extraction and in vitro screening of bioactive compounds from several plant samples. The extraction process yielded the following extract percentages: Antidesma bunius (2.28%), Cordia myxa (1.93%), Syzygium cumini (1.87%), and Syzygium malacense (2.97%). Subsequently, each sample was fractionated using n-hexane, ethyl acetate, and methanol. The extracts and fractions were then tested in vitro for their inhibitory activity against a-glucosidase enzyme using a microplate reader. The findings revealed that all extracts demonstrated notable inhibitory activity, with IC50 values of 5.66 ppm, 6.03 ppm, 6.17 ppm, and 6.13 ppm respectively. Importantly, these values are lower than the IC50 of the standard drug, Acarbose (6.85 ppm), highlighting the superior a-glucosidase inhibitory potential of the plant extracts. This indicates their promise as natural antidiabetic agents.
Cite this article:
Ahmad Najib, Muhammad Sulaiman Zubair, Muhammad Arba, Firzan Nainu, Hasnaeni, Virsa Handayani, Rezki Amriati Syarif. Antidiabetic Potential and Mechanism of Action Exploration of Sulawesi Ethnopharmacological Agents: In vitro Screening. Research Journal of Pharmacy and Technology. 2026;19(1):56-0. doi: 10.52711/0974-360X.2026.00009
Cite(Electronic):
Ahmad Najib, Muhammad Sulaiman Zubair, Muhammad Arba, Firzan Nainu, Hasnaeni, Virsa Handayani, Rezki Amriati Syarif. Antidiabetic Potential and Mechanism of Action Exploration of Sulawesi Ethnopharmacological Agents: In vitro Screening. Research Journal of Pharmacy and Technology. 2026;19(1):56-0. doi: 10.52711/0974-360X.2026.00009 Available on: https://rjptonline.org/AbstractView.aspx?PID=2026-19-1-9
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