Author(s):
Annapoorna Shenoy, Laxmish Mallya, Ankita Singh
Email(s):
laxmish.mallya@manipal.edu
DOI:
10.52711/0974-360X.2025.00660
Address:
Annapoorna Shenoy, Laxmish Mallya, Ankita Singh
Department of Conservative Dentistry and Endodontics, Manipal College of Dental Science Mangalore,
Manipal Academy of Higher Education, Karnataka, Manipal,576104, India.
*Corresponding Author
Published In:
Volume - 18,
Issue - 9,
Year - 2025
ABSTRACT:
The most prevalent malignancies in the modern era is head and neck cancer which has a considerate number of mortality and morbidity rate. Various Treatment approaches like surgery, radiation and chemotherapy have been utilized for the betterment of the patients. Even with such methodological protocols, oral cancer has relatively lower success rates. Hence this mandates a plethora of new treatment strategy which is the need of the hour. In order to lessen the burden of oral cancer on global health, ongoing efforts in prevention, early identification, and innovative treatment techniques are necessary. This systematic review addresses the medication side effects, prevention and management of various head and cancers.
Cite this article:
Annapoorna Shenoy, Laxmish Mallya, Ankita Singh. Drug-Induced Side effects in Head and Neck Cancer: A Comprehensive Review and Management Strategies. Research Journal of Pharmacy and Technology. 2025;18(9):4597-2. doi: 10.52711/0974-360X.2025.00660
Cite(Electronic):
Annapoorna Shenoy, Laxmish Mallya, Ankita Singh. Drug-Induced Side effects in Head and Neck Cancer: A Comprehensive Review and Management Strategies. Research Journal of Pharmacy and Technology. 2025;18(9):4597-2. doi: 10.52711/0974-360X.2025.00660 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-9-80
REFERENCES:
1. Bray F et al. Global cancer statistics, GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians. 2018; 68(6): 394–424. https://doi.org/10.3322/caac.21492
2. R Sangeetha, D Rajendiran, R Soniya, S Savithri. Therapeutic Strategies in Oral Cancer - A Review. Research Journal of Pharmacy and Technology. 2024; 17(3): 1398-2. doi: 10.52711/0974-360X.2024.00221
3. K Swapnil, S Vijay, M Chandrakant. Targeted Drug Delivery: A Backbone for Cancer Therapy. Asian Journal of Pharmaceutical Research. 2013; 3(1): 40-6. available on https://www.indianjournals.com/ijor.aspx?target=ijor:ajpr&volume=3&issue=1&article=009
4. UK Ramavat, PM Suneesh. A Study to Assess the Effectiveness of Flavoured Ice Cube on Level of Oral Mucositis among Cancer patients receiving Chemotherapy in selected Hospital, Rajkot. A and V Pub International Journal of Nursing and Medical Research. 2024; 3(2): 61-3. https://doi.org/10.52711/ijnmr.2024.12
5. Kalsi H, McCaul LK, Rodriguez JM. The role of primary dental care practitioners in the long-term management of patients treated for head and neck cancer. British Dental Journal. 2022; 233(9): 765-8. https://doi.org/10.1038/s41415-022-5148-z
6. Siegel RL, Miller KD, Wagle NS, Jemal A. Cancer statistics, 2023. CA: A Cancer Journal for Clinicians. 2023; 73(1): 17-48. (3) https://doi.org/10.3322/caac.21763
7. Marci Lee Nilsen et al. Late and long-term treatment-related effects and survivorship for head and neck cancer patients. Current Treatment Options in Oncology. 2020; 21: 1-4. https://doi.org/10.1007/s11864-020-00797-x
8. Brook I. Early side effects of radiation treatment for head and neck cancer. Cancer/ Radiotherapie. 2021; 25(5): 507-13. https://doi.org/10.1016/j.canrad.2021.02.001
9. Cardoso MD et al. Prevention and control of sequels in the mouth of patients treated with radiation therapy for head and neck tumors. Radiologia Brasileira. 2005; 38: 107-15. https://doi.org/10.1590/S0100-39842005000200006
10. Parra-Rojas S J et al. Oral Complications and Management Strategies for Cancer Patients: Principles of Supportive Oncology in Dentistry. Current Oncology Reports. 2024; 26(4): 391-9. https://doi.org/10.1007/s11912-024-01518-5
11. Rani RU. A Study to Assess the Knowledge regarding the side Effects of Chemotherapy among Cancer patients in selected Hospital, Bangalore. Asian Journal of Nursing Education and Research. 2021; 11(1): 83-5. http://dx.doi.org/10.5958/2349-2996.2021.00021.5
12. Singh M et al. Pharmacokinetic screening to Estimate the drug likeliness characteristics of selected Herbal Anticancer Drugs. Research Journal of Pharmacy and Technology. 2023; 16(7): 3422-6. http://dx.doi.org/10.52711/0974-360X.2023.00566
13. Deeming GM, Collingwood J, Pemberton MN. Methotrexate and oral ulceration. British dental journal. 2005; Jan; 198(2): 83-5. https://doi.org/10.1038/sj.bdj.4811972
14. De Pauli Paglioni M et al. The impact of radiation caries in the quality of life of head and neck cancer patients. Supportive Care in Cancer. 2020; Jun; 28: 2977-84. https://doi.org/10.1007/s00520-019-05171-8
15. Basu T et al. Toxicity with radiotherapy for oral cancers and its management: A practical approach. Journal of Cancer Research and Therapeutics. 2012; 8 (Suppl 2): S72-84. https://doi.org/10.4103/0973-1482.92219
16. Vives-Soler A, Lopez-Lopez J, Jane-Salas E. Radiation-induced xerostomia: update. Radiation-induced xerostomia: update. Revista Colombiana de Cancerología. 2017; 21(1): 26-32 https://doi.org/10.1016/j.rccan.2016.06.001
17. Hancock PJ, Epstein JB, Sadler GR. Before Treatment OA. Oral and dental management related to radiation therapy for head and neck cancer. J Can Dent Assoc. 2003; 69(9): 585-90.
18. Ribeiro IL et al Oral mucositis in pediatric patients in treatment for acute lymphoblastic leukemia. International Journal of Environmental Research and Public Health. 2017; 14(12): 1468. https://doi.org/10.3390/ijerph14121468
19. R Tayyar D Ho. Herpes simplex virus and varicella zoster virus infections in cancer patients. Viruses. 2023; 15(2): 439. https://doi.org/10.3390/v15020439
20. K Anjali et al. Oral microbial profile in oral cancer patients before and after radiation therapy in a cancer care center - A prospective study. Journal of Oral and Maxillofacial Pathology. 2020; 24(1): 117-24. https://doi.org/10.4103/jomfp.jomfp_213_19
21. Jawad H, Hodson NA, Nixon PJ. A review of dental treatment of head and neck cancer patients, before, during and after radiotherapy: part 1. British Dental Journal. 2015; 218(2): 65-8. https://doi.org/10.1038/sj.bdj.2015.28
22. Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature. 2008; 454(7203): 436-44. https://doi.org/10.1038/nature07205
23. Epstein JB et al. Oral complications of cancer and cancer therapy: from cancer treatment to survivorship. CA: A Cancer Journal for Clinicians. 2012; 62(6): 400-22. https://doi.org/10.3322/caac.21157
24. da Cruz Campos MI, Neiva Campos C, Monteiro Aarestrup F, Vieira Aarestrup BJ. Oral mucositis in cancer treatment: Natural history, prevention and treatment. Molecular and Clinical Oncology. 2014; 2(3): 337-40. https://doi.org/10.3892/mco.2014.253
25. Dijkstra PU, Kalk WW, Roodenburg JL. Trismus in head and neck oncology: a systematic review. Oral oncology. 2004; Oct 1; 40(9): 879-89. https://doi.org/10.1016/j.oraloncology.2004.04.003
26. Vaughan E D. An analysis of morbidity following major head and neck surgery with particular reference to mouth function. J Maxillofac Surg 1982; 10: 129–134. (21) https://doi.org/10.1016/s0301-0503(82)80027-1
27. Teguh DN et al. Trismus in patients with oropharyngeal cancer: relationship with dose in structures of mastication apparatus. Head and Neck: Journal for the Sciences and Specialties of the Head and Neck. 2008; 30(5): 622-30. https://doi.org/10.1002/hed.20760
28. Dijkstra PU, Huisman PM, Roodenburg JL. Criteria for trismus in head and neck oncology. International Journal of Oral and Maxillofacial Surgery. 2006; 35(4): 337-42. https://doi.org/10.1016/j.ijom.2005.08.001
29. Lopes MA et al. Reconhecendo e controlando os efeitos colaterais da radioterapia. Rev. Assoc. Paul. Cir. Dent. 1998:241-4.
30. De Almeida Silva LA et al. The incidence of osteoradionecrosis of the jaws in oral cavity cancer patients treated with intensity-modulated radiotherapy: A systematic review and meta-analysis. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2024; 18. https://doi.org/10.1016/j.oooo.2024.04.008
31. Taichman LS, Gomez G, Inglehart MR. Oral health-related complications of breast cancer treatment: assessing dental hygienists' knowledge and professional practice. American Dental Hygienists' Association. 2015; 89(2): 22-37. (1)
32. Baum BJ. et al. Therapy‐induced dysfunction of salivary glands: implications for oral health. Special Care in dentistry. 1985; 5(6): 274-7. https://doi.org/10.1111/j.1754-4505.1985.tb00593.x
33. Epstein JB, Lunn R, Le N, Stevenson Moore P. Periodontal attachment loss in patients after head and neck radiation therapy. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 1998; 86(6): 673-7. https://doi.org/10.1016/s1079-2104(98)90202-5
34. Barclay SC, Turani D. Current practice in dental oncology in the UK. Dental update. 2010; 37(8): 555-61. https://doi.org/10.12968/denu.2010.37.8.555
35. Chamberlain MC. Neurotoxicity of cancer treatment. Current oncology reports. 2010; 12(1): 60-7. https://doi.org/10.1007/s11912-009-0072-9
36. Dietrich J. Neurotoxicity of cancer therapies. Continuum: Lifelong Learning in Neurology. 2020; 26(6): 1646-72. https://doi.org/10.1212/con.0000000000000943
37. Sen A et al. Current Therapy in Cancer: Advances, Challenges, and Future Directions. Asian Journal of Nursing Education and Research. 2024; 14(1): 77-84. http://dx.doi.org/10.52711/2349-2996.2024.00016
38. Kaur S, Mayanglambam P, Bajwan D, Thakur N. Chemotherapy and its adverse effects-A systematic review. International Journal of Nursing Education and Research. 2022; 10(4): 399-402. http://dx.doi.org/10.52711/2454-2660.2022.00090
39. B Arya, K Krishnaveni, R Sambathkumar. Review on Antioxidant Supplements use in Cancer Chemotherapy. Research Journal of Pharmacology and Pharmacodynamics. 2020; 12(1): 21-4. https://doi.org/10.5958/2321-5836.2020.00005.1
40. Umeda M et al. Lack of survival advantage in patients with advanced, resectable squamous cell carcinoma of the oral cavity receiving induction chemotherapy with cisplatin (CDDP), docetaxel (TXT) and 5-fluorouracil (5FU). Kobe Journal of Medical Sciences. 2004; 50(5/6): 189. (11) available on https://pubmed.ncbi.nlm.nih.gov/16107776/
41. Pasricha JS et al. Dexamethasone‐cyclophosphamide pulse therapy for pemphigus. International Journal of Dermatology. 1995; 34(12): 875-82. (12) https://doi.org/10.1111/j.1365-4362.1995.tb04430.x
42. Fuwa N et al. A combination therapy of continuous super selective intraarterial carboplatin infusion and radiation therapy for locally advanced head and neck carcinoma: a phase I study. Cancer: Interdisciplinary International Journal of the American Cancer Society. 2000; Nov 15; 89(10): 2099-105 available on https://pubmed.ncbi.nlm.nih.gov/11066051/
43. Dahllof G, Barr M, Bolme P. Disturbances in dental development after total body irradiation in bone marrow transplant recipients. Oral Surg Oral Med Oral Pathol. 1988; 65(1): 41-4. doi: 10.1016/0030-4220(88)90189-2. PMID: 2963247
44. Jensen SB, Mouridsen HT, Reibel J, Brunner N, Nauntofte B. Adjuvant chemotherapy in breast cancer patients induces temporary salivary gland hypofunction. Oral Oncol. 2008; 44(2): 162-73. doi: 10.1016/j.oraloncology.2007.01.015. Epub 2007; Jun 27. PMID: 17588802.
45. Çetiner D et al. Oral and dental alterations and growth disruption following chemotherapy in long-term survivors of childhood malignancies. Supportive Care in Cancer. 2019; 27: 1891-9 https://doi.org/10.1007/s00520-018-4454-0
46. Poulopoulos A, Papadopoulos P, Andreadis D. Chemotherapy: oral side effects and dental interventions-a review of the literature. Stomatological Disease and Science. 2017; 29; 1: 35-49. https://doi.org/10.20517/2573-0002.2017.03
47. Debnath S et al. Impurity Linked Genotoxicity assessment of the Antineoplastic Chemotherapy agent using Ames model. Research Journal of Pharmacy and Technology. 2023; 16(7): 3339-42 http://dx.doi.org/10.52711/0974-360X.2023.00551
48. Lopez BC, Esteve CG, Perez MS. Dental treatment considerations in the chemotherapy patient. J Clin Exp Dent. 2011; 3(1): 31-42.
49. Hong CH et al. Dental Disease Section, Oral Care Study Group, Multi-national Association of Supportive Care in Cancer (MASCC) /International Society of Oral Oncology (ISOO). A systematic review of dental disease in patients undergoing cancer therapy. Supportive care in cancer. 2010; 18: 1007-21. https://doi.org/10.1007/s00520-010-0873-2
50. Caribe Gomes F et al. Dental management of the complications of radio and chemotherapy in oral cancer. Medicina Oral. 2003; 8(3): 178-87.
51. S A Fayle . M S Duggal. S A Williams. Oral problems and the dentist's role in the management of paediatric oncology patients. Dental Update. 1992; 19(4): 152-6.
52. Kumar N et al. The oral management of oncology patients requiring radiotherapy, chemotherapy and or bone marrow transplantation. Faculty Dental Journal. 2013; 4(4): 200-3. https://doi.org/10.1308/204268513x13776914744952
53. McCaul LK. Oral and dental management for head and neck cancer patients treated by chemotherapy and radiotherapy. Dental update. 2012; 39(2): 135-40. https://doi.org/10.12968/denu.2012.39.2.135
54. Jisha K et al. The Influence of Pharmacogenetics in Cancer Chemotherapy. Research Journal of Pharmacology and Pharmacodynamics. 2020; 12(1): 29-33 http://dx.doi.org/10.5958/2321-5836.2020.00007.5