ABSTRACT:
Peptic ulcer disease, which includes gastric and duodenal ulcers, is one of the most widespread gastrointestinal conditions, affecting 10% of the global population. The main cause of this disease was continuous imbalance between aggressive and defensive factors as elevation of aggressive factors increases levels of pepsin gastric acid secretion and decreases bicarbonate ions. NSAIDS (non-steroidal anti-inflammatory drugs), Alcohol, Smoking, H. pylori infections are the factors which are responsible for disrupting Gastric acid secretion and leads to formation of ulcers. Conventional drugs like PPIs, H2 receptor blockers, Prostaglandin analogues has shown various side effects. Hence, the phytochemicals found in medicinal plants, such as flavonoids and polyphenols, are a rich supply of polyphenolic substances that may be used to treat a variety of ailments. In this review, we summarized available literature with the help of ‘PubMed’, ‘Google Scholar’, and ‘Scopus’, etc. Here, Probiotics, isolated phytochemical substances, common medicinal plants, and green synthesis of plant extracts have all been utilized to treat peptic ulcers.
Cite this article:
Susmita Yadav, Anima Pandey. Recent Advancements in Principle Secondary Metabolites and Their Antiulcer Inhibitory effects. Research Journal of Pharmacy and Technology. 2025;18(9):4555-3. doi: 10.52711/0974-360X.2025.00654
Cite(Electronic):
Susmita Yadav, Anima Pandey. Recent Advancements in Principle Secondary Metabolites and Their Antiulcer Inhibitory effects. Research Journal of Pharmacy and Technology. 2025;18(9):4555-3. doi: 10.52711/0974-360X.2025.00654 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-9-74
REFERENCES:
1. El-Demerdash AA. Menze ET. Esmat A. Tadros M.G. Elsherbiny D.A. Protective and therapeutic effects of the flavonoid “pinocembrin” in indomethacin-induced acute gastric ulcer in rats: Impact of anti-oxidant, anti-inflammatory, and anti-apoptotic mechanisms. Naunyn-Schmiedeberg's Archives of Pharmacology 2021; 394: 1411-1424. https://doi.org/10.1007/s00210-021-02067-5
2. Lee JH. Lee SH. Kim YS. Jeong CS. Protective effects of neohesperidin and poncirin isolated from the fruits of Poncirus trifoliata on potential gastric disease. Phytotherapy Research 2009; 23: 1748-1753.
3. Miranda MA. Lemos M. Cowart KA. Rodenburg D. McChesney J.D. Radwan M.M. Furtado N.A.J.C. Bastos J.K. Gastroprotective activity of the hydroethanolic extract and isolated compounds from the leaves of Solanum cernuum Vell. Journal of Ethnopharmacology. 2015; 172: 421-429. https://doi.org/10.1016/j.jep.2015.06.047
4. Belagihally SM. Rajashekhar S. Jayaram VB. Dharmesh SM. Thirumakudalu SKC. Gastroprotective properties of karanjin from Karanja (Pongamia pinnata) seeds; Role as antioxidant and H+, K+-ATPase inhibitor. Evidence-Based Complementary and Alternative Medicine. 2011: 1-9. https://doi.org/10.1093/ecam/neq027
5. Tuerk E. Doss S. Polsley K. Peptic Ulcer Disease. Primary Care: Clinics in Office Practice 2023.
6. Xie X. Ren K. Zhou Z. Dang C. Zhang H. The global, regional and national burden of peptic ulcer disease from 1990 to 2019: a population-based study. BMC Gastroenterology 2022; 22: 58-62.
7. Levenstein S. The very model of a modern etiology: a biopsychosocial view of peptic ulcer. Psychosomatic Medicine 2009; 62:176-185.
8. Wang AY. Peura DA. The prevalence and incidence of Helicobacter pylori–associated peptic ulcer disease and upper gastrointestinal bleeding throughout the world. Gastrointestinal Endoscopy Clinics 2011; 21: 613-635.
9. Van der Hulst. RWM. Tytgat GNJ. Helicobacter pylori and peptic ulcer disease. Scandinavian Journal of Gastroenterology. 1996; 31: 10-18.
10. Khan MSA. Khundmiri SUK. Khundmiri SR. Al-Sanea MM. Mok PL. Fruit-derived polysaccharides and terpenoids: Recent update on the gastroprotective effects and mechanisms. Frontiers in Pharmacology. 2018; 9, 569.
11. Júnior GMV. da Rocha CQ. de Souza Rodrigues T. Hiruma-Lima CA. Vilegas W. New steroidal saponins and antiulcer activity from Solanum paniculatum L. Food Chemistry. 2015; 186: 160-167. https://doi.org/10.1016/j.foodchem.2014.08.005
12. Patel JM. A review of potential health benefits of flavonoids. 2008; 3: 1-5.
13. Zhang W. Lian Y. Li Q. Sun L. Chen R., Lai X. Lai Z. Yuan E. Sun S. Preventative and therapeutic potential of flavonoids in peptic ulcers. Molecules 2020; 25: 4626.
14. Serafim C. Araruna ME. Júnior EA. Diniz M. Hiruma-Lima C. Batista L. A review of the role of flavonoids in peptic ulcer (2010–2020). Molecules. 2020; 25: 5431-5436.
15. Bigoniya P. Singh K. Ulcer protective potential of standardized hesperidin, a citrus flavonoid isolated from Citrus sinensis. Revista Brasileira de Farmacognosia. 2014; 24: 330-340. https://doi.org/10.1016/j.bjp.2014.07.011
16. Ustün O. Ozçelik B. Akyön Y. Abbasoglu U. Yesilada E. Flavonoids with anti-Helicobacter pylori activity from Cistus laurifolius leaves. Journal of Ethnopharmacology. 2006; 108: 457-461. https://doi.org/10.1016/j.jep.2006.06.001
17. Lewis DA. Fields WN. Shaw GP. A natural flavonoid present in unripe plantain banana pulp (Musa sapientum L. var. paradisiaca) protects the gastric mucosa from aspirin-induced erosions. Journal of Ethnopharmacology. 1999; 65: 283-288. https://doi.org/10.1016/S0378-8741(99)00005-7
18. Díaz-Gómez R. López-Solís R. Obreque-Slier E. Toledo-Aray H. Comparative antibacterial effect of gallic acid and catechin against Helicobacter pylori. LWT-Food Science and Technology. 2013; 54: 331-335. https://doi.org/10.1016/j.lwt.2013.07.012
19. De Barros M. Mota da Silva L. Boeing T. Somensi L.B. Cury B.J. de Moura Burci L. Santin JR. de Andrade. S.F. Monache FD. Cechinel-Filho V. Pharmacological reports about gastroprotective effects of methanolic extract from leaves of Solidago chilensis (Brazilian arnica) and its components quercitrin and afzelin in rodents. Naunyn-Schmiedeberg's archives of Pharmacology 2016; 389: 403-417. DOI https://doi.org/ 10.1007/s00210-015-1208-0
20. Yesilada E. Gürbüz İ. Toker G. Anti-ulcerogenic activity and isolation of the active principles from Sambucus ebulus L. leaves. Journal of Ethnopharmacology. 2014; 153: 478-483. https://doi.org/10.1016/j.jep.2014.03.004
21. Gilani SJ. Bin-Jumah MN. Al-Abbasi FA. Nadeem MS. Imam SS. Alshehri S. Ahmed M.M. Ghoneim MM. Afzal M. Alzarea SI. Sayyed N. Protective effect of fustin against ethanol-activated gastric ulcer via downregulation of biochemical parameters in rats. ACS Omega. 2022; 7: 23245-23254.
22. Awaad AS. Mohamed NH. Maitland DJ. Soliman GA. Anti-ulcerogenic Activity of Extract and Some Isolated Flavonoids from Desmostachia bipinnata (L.) Stapf. Records of Natural Products. 2008; 2.
23. Garro MF. Ibáñez AGS. Vega AE. Sosa ACA. Pelzer L. Saad JR. Maria AO. Gastroprotective effects and antimicrobial activity of Lithraea molleoides and isolated compounds against Helicobacter pylori. Journal of Ethnopharmacology. 2015; 176: 469-474. https://doi.org/10.1016/j.jep.2015.11.009
24. Baggio CH. Freitas CS. de Martini Otofuji G. Cipriani TR. de Souza LM. Sassaki GL. Iacomini M. Marques MCA. Mesia-Vela S. Flavonoid-rich fraction of Maytenus ilicifolia Mart. ex. Reiss protects the gastric mucosa of rodents through inhibition of both H+, K+-ATPase activity and formation of nitric oxide. Journal of Ethnopharmacology. 2007; 113: 433-440. https://doi.org/10.1016/j.jep.2007.06.015
25. Kataoka M. Hirata K. Kunikata T. Ushio S. Iwaki K. Ohashi K. Ikeda M. Kurimoto M. Antibacterial action of tryptanthrin and kaempferol, isolated from the indigo plant (Polygonum tinctorium Lour.), against Helicobacter pylori-infected Mongolian gerbils. Journal of Gastroenterology. 2001; 36: 5-9.
26. Anand SJT. Sara B. A study to assess the effectiveness of Video Teaching Programme on Diet and Stress Management among patients with Peptic Ulcer Disease in RMMCH, Annamalai University, Chidambaram. Asian Journal of Nursing Education and Research. 2015; 5: 389-391.
27. Mahurkar N. Sayeed Ul Hasan SM. Synergistic Antiulcer Effect of Melatonin and Esomeprazole Combination in Pylorus Ligation, Ethanol, Aspirin induced Peptic Ulcers. Asian Journal of Pharmaceutical Research. 2015; 5: 10-14.
28. Meshram N. Ojha M. Singh A. Alexander A. Sharma M. Significance of medicinal plant used for the treatment of peptic ulcer. Asian Journal of Pharmacy and Technology. 2015; 5: 32-37.
29. Ramesh KD. Navnath KA. Babasaheb PJ. Formulation and in-vitro Evaluation of floating tablets of Antibiotics used in the treatment of Peptic ulcer. Asian Journal of Pharmacy and Technology. 2021; 11: 18-26.
30. Abhipsa V. Manasa M. Poornima G. Rekha C. Kekuda TR. In vitro antibacterial efficacy of selected plant extracts, streptomycin and their combination. Asian Journal of Research In Chemistry. 2012; 5: 791-793.
31. Sara MO. Elhadi NM. Abdelkhalig MM. Anti-Inflammatory Activity of Some Indigenous Sudanese Plants. Research Journal of Pharmacognosy and Phytochemistry. 2014; 6: 30-32.
32. Madan NV. Sahu MS. Jambhulkar YT. Mamidwar AS. Hingawe NT. Maliye AN. A Review on Euphorbiaceae plants for peptic ulcer. Research Journal of Pharmacognosy and Phytochemistry. 2018; 10: 336-339.
33. Laware R. Bharskar G. Chavan S. Borude G. A Review on Polyherbal Antiulcer Formulations. Research Journal of Pharmacognosy and Phytochemistry. 2022; 14: 89-97.
34. Prasad K. Nitin M. Chetan M. Girish M. Kumar K. Antiulcer Effect of Vitamin E with Lansoprazole in Treating Peptic Ulcer in Rats. Research Journal of Pharmacology and Pharmacodynamics. 2011; 3: 202-206.
35. Pandey A. Saraswat N. Wal P. Pal RS. Wal A. Maurya D. A detailed review on: recent advances, pathophysiological studies and mechanism of peptic ulcer. Research Journal of Pharmacology and Pharmacodynamics. 2019; 11: 165-170.
36. Venkatesan H. Retrospective analytical case series study on the acid peptic disorders treated with homoeopathic medications. Research Journal of Pharmacology and Pharmacodynamics. 2020; 12: 97-100.
37. Yadav S. Pandey A. Mali SN. From Lab to Nature: Recent Advancements in the Journey of Gastroprotective Agents from Medicinal Chemistry to Phytotherapy. European Journal of Medicinal Chemistry. 2024; 116-436.