ABSTRACT:
Gentamicin (Aminoglycoside antibiotic) is notorious for causing kidney problems in both humans and animals. Tabernaemontana divaricata, a plant containing flavonoids, tannins, terpenoids and other compounds known to benefit kidneys health, is under investigation for its potential to mitigate gentamicin-induced kidney damage in Wistar rats. Adult Rats (Strain -Wistar and Sex-Female) has been divided into 4 separate groups to assess the nephroprotective and nephrocurative effects of T.divaricata in gentamicin- induced nephrotoxicity. The experimental setup was as follows: Group I received water for 28 days (control); Group II received gentamicin for 8 days (Nephrotoxic control); Group III received ethanolic extract of T. divaricata for 8 days (Nephroprotective) and Group IV received gentamicin for 8 days followed by ethanaolic extract of T. divaricata from day 9 to 28 (Nephrocurative). This improvement was marked by significant reductions in serum uric acid concentrations along with a decrease in urinary total protein levels, despite an increase in serum total protein levels. Notably, T.divaricata treated nephrocurative animals exhibited superior recovery compared to those receiving nephroprotective treatment alone. In the foreseeable future, the bioactive compounds present in T.divaricata could emerge as promising therapeutic agents for renal disorders. This suggests that T.divaricata might shield against kidney dysfunctions triggered by oxidative stress. However, further exploration through clinical trials and detailed research involving metabolomics and new biomarkers is recommended to better understand the potential health benefits of T.divaricata compounds for renal health.