Author(s):
Vedanshu Malviya, Ekant Taywade, Gaurav Ingle, Gunjan Malode, Mayuri Jadhav
Email(s):
vedanshumlv56@gmail.com
DOI:
10.52711/0974-360X.2025.00641 
Address:
Vedanshu Malviya1*, Ekant Taywade2, Gaurav Ingle1, Gunjan Malode1, Mayuri Jadhav3
1Department of Pharmaceutics, School of Pharmacy, GH Raisoni University, Amravati – 444701.
2Department of Pharmaceutical Chemistry, Dr. Rajendra Gode Institute of Pharmacy, Amravati – 444602.
3Department of Pharmaceutical Chemistry, MVP Samaj's College of Pharmacy, Nashik, Maharashtra – 422002.
*Corresponding Author
Published In:
Volume - 18,
Issue - 9,
Year - 2025
ABSTRACT:
Rheumatoid arthritis, a major joint pain problem in the elderly, has led to increased research on its causes and treatment. This study aims to develop an implant formulation of Ibuprofen using plain drug, cross-linked chitosan, and chitosan as release retardant matrix. The implants were evaluated for optimal formulation to achieve maximum sustained effect over specific days. The drug and polymer were found to be compatible, with drug content ranging from 91.67-99.62%, diameter ranging from 7.15-7.40mm, hardness ranging from 2.6-3.4kg/cm3, thickness ranging from 2.22-2.59mm, and weight ranging from 93.2-101.2mg resp. The formulation A4 and A5 showed sustained action compared to other formulations of both cross-linked and non-cross-linked batches. The study concludes that chitosan inclusion changes the drug's release profile, resulting in sustained action on the prepared implants.
Cite this article:
Vedanshu Malviya, Ekant Taywade, Gaurav Ingle, Gunjan Malode, Mayuri Jadhav. Effect of Cross-Linking on the Pattern on Drug Release in Chitosan Based Ibuprofen Implants. Research Journal of Pharmacy and Technology. 2025;18(9):4469-6. doi: 10.52711/0974-360X.2025.00641
Cite(Electronic):
Vedanshu Malviya, Ekant Taywade, Gaurav Ingle, Gunjan Malode, Mayuri Jadhav. Effect of Cross-Linking on the Pattern on Drug Release in Chitosan Based Ibuprofen Implants. Research Journal of Pharmacy and Technology. 2025;18(9):4469-6. doi: 10.52711/0974-360X.2025.00641 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-9-61
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