Author(s):
Amrita Nayak, Rama Prasad Padhy, Deepak Kumar Bhatta, Gourhari Pal, Bhuneswari Bareha, Aanchal Gupta
Email(s):
amritanayak0002@gmail.com , rampadhy@gmail.com , deepakkumarbhatta222@gmail.com , gourharipal560@gmail.com , bhuneshwaribariha941@gmail.com , guptaaanchal166@gmail.com
DOI:
10.52711/0974-360X.2025.00573 
Address:
Amrita Nayak1*, Rama Prasad Padhy2, Deepak Kumar Bhatta3, Gourhari Pal4, Bhuneswari Bareha5, Aanchal Gupta6
1Assistant Professor, Danteswari College of Pharmacy, Borpadar, Raipur-Road, Jagdalpur, C.G. 494221.
2Professor, Danteswari College of Pharmacy, Borpadar, Raipur-Road, Jagdalpur, C.G. 494221.
3B.Pharm 7th Semester Student, Danteswari College of Pharmacy, Borpadar, Raipur-Road, Jagdalpur-494221.
4B.Pharm 7th Semester Student, Danteswari College of Pharmacy, Borpadar, Raipur-Road, Jagdalpur – 494221.
5B.Pharm 7th Semester Student, Danteswari College of Pharmacy, Borpadar, Raipur-Road, Jagdalpur – 494221.
6B.Pharm 7th Semester Student, Danteswari College of Pharmacy, Borpadar, Raipur-Road, Jagdalpur – 494221.
*Corresponding Author
Published In:
Volume - 18,
Issue - 8,
Year - 2025
ABSTRACT:
Solubility is the essential ability of any solute to be dissolved in any solution at different parameters. It has been evaluated that, about 30-50% of medicaments have poor solubility and dissolution rate. One of the key factors influencing a drug's bioavailability and pharmacokinetics is its solubility. These poorly soluble drugs can lead to gastro intestinal, mucosal toxicity and reduced pharmacological action. It is among the most significant issues encountered during the planning and creation of NCEs. The Biopharmaceutical Classification System [BCS] is known as the highly advanced methodology to differentiate the drug substances on the basis of their Solubility and Permeability. This methodology is widely used for management in the early development process of medications and in the identification of NCEs along with drug discovery process. Currently, there are several techniques used for enhancing aqueous solubility of drugs for greater bioavailability and increased therapeutics. Throughout the decade, various traditional approaches have been utilised to enhance the solubility of medicinal compounds.
Cite this article:
Amrita Nayak, Rama Prasad Padhy, Deepak Kumar Bhatta, Gourhari Pal, Bhuneswari Bareha, Aanchal Gupta. Advanced Techniques in Solubility Enhancement of Poorly Water-Soluble Drugs. Research Journal Pharmacy and Technology. 2025;18(8):3987-4. doi: 10.52711/0974-360X.2025.00573
Cite(Electronic):
Amrita Nayak, Rama Prasad Padhy, Deepak Kumar Bhatta, Gourhari Pal, Bhuneswari Bareha, Aanchal Gupta. Advanced Techniques in Solubility Enhancement of Poorly Water-Soluble Drugs. Research Journal Pharmacy and Technology. 2025;18(8):3987-4. doi: 10.52711/0974-360X.2025.00573 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-8-76
REFERENCE:
1. Kumari L, Choudhari Y, Patel P, Gupta G Das, Singh D, Rosenholm JM, et al. Advancement in Solubilization Approaches: A Step towards Bioavailability Enhancement of Poorly Soluble Drugs. Life. MDPI. 2023;13.
2. Ainurofiq A, Putro DS, Ramadhani DA, Putra GM, Do Espirito Santo LDC. A review on solubility enhancement methods for poorly water-soluble drugs. Vol. 10, Journal of Reports in Pharmaceutical Sciences. 2021: 137–47.
3. Belsarkar AS, Patil RN, Parekar PB, Sul KT, More A V. International Journal of Current Science Research and Review A Brief Review on Solubility Enhancement Techniques with Drug and Polymer. Available from: www.ijcsrr.org
4. Pawar SR, Barhate SD. Solubility enhancement (Solid Dispersions) novel boon to increase bioavailability. Journal of Drug Delivery and Therapeutics. 2019; 9(2): 583–90.
5. Vimalson DC, Parimalakrishnan S, Jeganathan NS, Anbazhagan S. Techniques to Enhance Solubility of Hydrophobic Drugs: An Overview. Asian Journal of Pharmaceutics. 10,
6. Bhalani D V., Nutan B, Kumar A, Singh Chandel AK. Bioavailability Enhancement Techniques for Poorly Aqueous Soluble Drugs and Therapeutics. Biomedicines. MDPI. 2022; 10.
7. Tan J, Liu J, Ran L. A review of pharmaceutical nano-cocrystals: A novel strategy to improve the chemical and physical properties for poorly soluble drugs. Crystals. MDPI AG. 2021; 11.
8. Solanki SS, Soni LK, Maheshwari RK. Study on Mixed Solvency Concept in Formulation Development of Aqueous Injection of Poorly Water Soluble Drug. J Pharm (Cairo). 2013; 2013: 1–8.
9. Tomal W, Ortyl J. Water-soluble photoinitiators in biomedical applications. Polymers. MDPI AG. 2020;12.
10. Tiwari R, Tiwari G, Srivastava B, Rai AK. Solid Dispersions: An Overview To Modify Bioavailability Of Poorly Water Soluble Drugs. International Journal of PharmTech Research. 1
11. Kumar A, Sahoo SK, Padhee K, Pal P, Kochar S, Satapathy A, et al. Pharmacie Globale International Journal of Comprehensive Pharmacy Review On Solubility Enhancement Techniques For Hydrophobic Drugs. Pharmacie Globale (IJCP). 2011. Available from: www.pharmacie-globale.info
12. Kushare SS, Gattani SG. Microwave-generated bionanocomposites. Journal of Pharmacy and Pharmacology. 2013; 65(1): 79–93.
13. Mahapatra APK, Patil V, Patil R. Solubility Enhancement of Poorly soluble Drugs by using Novel Techniques : A Comprehensive Review. Int J Pharmtech Res. 2020; 13(2): 80–93.
14. Kumar A, Sahoo SK, Padhee K, Pal P, Kochar S, Satapathy A, et al. Pharmacie Globale International Journal of Comprehensive Pharmacy Review On Solubility Enhancement Techniques For Hydrophobic DRUGS. Pharmacie Globale (IJCP). 2011. Available from: www.pharmacie-globale.info
15. Budiman A, Rusdin A, Aulifa DL. Current Techniques of Water Solubility Improvement for Antioxidant Compounds and Their Correlation with Its Activity: Molecular Pharmaceutics. Antioxidants. MDPI. 2023; 12
16. Gupta R, Jain V, Nagar JC, Ansari A, Sharma K, Sarkar A, et al. Bioavailability Enhancement Techniques for Poorly Soluble Drugs: A Review. Asian Journal of Pharmaceutical Research and Development. 2020; 8(2): 75–8.
17. Chouhan M, Rathor S, Garg V, Sharma A, Singh P, Chandra J, et al. Enhancement Of Solubility And Dissolution Characteristics Of Etoricoxib By Solid Dispersion Technique Using Different Grade Of Peg Carrier Using. Journal of Pharmaceutical Negative Results. 14.
18. Yadav K, Sachan AKr, Kumar S, Dubey A. Techniques For Increasing Solubility: A Review Of Conventional And New Strategies. Asian Journal of Pharmaceutical Research and Development. 2022; 10(2): 144–53.
19. Thorat YS, Gonjari ID, Hosmani AH. Solubility Enhancement Techniques: A Review On Conventional and Novel Approaches. IJPSR [Internet]. 2011; 2(10). Available from: www.ijpsr.com
20. Nanotechnology A promising Drug Delivery for Poorly Water Soluble Drugs. 2010
21. Gupta S, Sawarkar S, Ravikumar P. Solubility Enhancement of Poorly Water Soluble Protease Inhibitor. Int J Pharm Sci Res [Internet]. 2016; 7(1): 252–8.
22. van der Merwe J, Steenekamp J, Steyn D, Hamman J. The role of functional excipients in solid oral dosage forms to overcome poor drug dissolution and bioavailability. Pharmaceutics. MDPI AG. 2020; 12
23. Kim DH, Kim YW, Tin YY, Soe MTP, Ko BH, Park SJ, et al. Recent technologies for amorphization of poorly water-soluble drugs. Pharmaceutics. MDPI. 2021; 13
24. Savjani KT, Gajjar AK, Savjani JK. Drug Solubility: Importance and Enhancement Techniques. ISRN Pharm. 2012; 2012: 1–10.
25. Jain P, Goel A, Sharma S, Parmar M. International Journal Of Pharma Professional’s Research Solubility Enhancement Techniques With Special Emphasis On Hydrotrophy [Internet]. 2010; 1. Available from: www.ijppronline.com
26. Lee MK. Liposomes for enhanced bioavailability of water-insoluble drugs: In vivo evidence and recent approaches. Pharmaceutics. MDPI AG. 2020; 12
27. Rupvate SR, Gangurde SA, Adavadkar PR, Ukhade SS, Lale SS. Solid self-emulsifying pellets: Solubility enhancement for oral delivery of poorly soluble BCS Class II drug. Journal of Drug Delivery and Therapeutics. 2022; 12(4-S): 171–6.
28. 2022-Solubility Enhancement Techniques of Anti-Microbial Agents of BCS Class II and IV Drugs.
29. Jagtap S, Magdum C, Jadge D, Jagtap R. Solubility Enhancement Technique: A Review.
30. Samineni R, Chimakurthy J, Konidala S. Emerging Role of Biopharmaceutical Classification and Biopharmaceutical Drug Disposition System in Dosage form Development: A Systematic Review. Vol. 19, Turkish Journal of Pharmaceutical Sciences. Turkish Pharmacists Association. 2022. 706–13.
31. Khatri H, Hussain S, Tyagi S, Sadique Hussain M. Solubility Enhancement Techniques: An Overview. Certified Journal│ Hussain et al World Journal of Pharmaceutical Research [Internet]. 2022;11. Available from: www.wjpr.net
32. Rupvate SR, Gangurde SA, Adavadkar PR, Ukhade SS, Lale SS. Solid self-emulsifying pellets: Solubility enhancement for oral delivery of poorly soluble BCS Class II drug. Journal of Drug Delivery and Therapeutics. 2022; 12(4-S): 171–6.
33. Mahapatra APK, Patil V, Patil R. Solubility Enhancement of Poorly soluble Drugs by using Novel Techniques : A Comprehensive Review. Int J Pharmtech Res. 2020; 13(2): 80–93.
34. S. Belsarkar A, N. Patil R, B. Parekar P, T. Sul K, V. More A. A Brief Review on Solubility Enhancement Techniques with Drug and Polymer. International Journal of Current Science Research and Review [Internet]. 2022; 5(12). Available from: https://ijcsrr.org/single-view/?id=8271&pid=8124
35. Arun Kumar MS, Rajesh M, Subramanian L. Solubility enhancement techniques: A comprehensive review. World Journal of Biology Pharmacy and Health Sciences. 2023; 13(3): 414–149.
36. Kumari L, Choudhari Y, Patel P, Gupta G Das, Singh D, Rosenholm JM, et al. Advancement in Solubilization Approaches: A Step towards Bioavailability Enhancement of Poorly Soluble Drugs. Life. MDPI. 2023; 13.
37. Cb G, Al B, Ab G. A Concise Review on Methods of Solubility Enhancement. Review Article Int J Pharm Sci [Internet]. 2020 Available from: https://ipharmsciencia.edwiserinternational.com/home.php
38. Alik Kumar L, Pattnaik G, Satapathy BS, Patro CS, Naik S, Dash AK, et al. Solubility Enhancement Techniques: Updates and Prospectives. Journal of Pharmaceutical Negative Results. 2022; 13
39. Ainurofiq A, Putro DS, Ramadhani DA, Putra GM, Do Espirito Santo LDC. A review on solubility enhancement methods for poorly water-soluble drugs. Vol. 10, Journal of Reports in Pharmaceutical Sciences. Wolters Kluwer Medknow Publications. 2021: 137–47.
40. Bhalani D V., Nutan B, Kumar A, Singh Chandel AK. Bioavailability Enhancement Techniques for Poorly Aqueous Soluble Drugs and Therapeutics. Biomedicines. MDPI; 2022;10
41. Jain P, Goel A, Sharma S, Parmar M. International Journal Of Pharma Professional’s Research Solubility Enhancement Techniques With Special Emphasis On Hydrotrophy [Internet]. 2010; 1. Available from: www.ijppronline.com
42. Kumar A, Sahoo SK, Padhee K, Pal P, Kochar S, Satapathy A, et al. Pharmacie Globale International Journal Of Comprehensive Pharmacy Review On Solubility Enhancement Techniques For Hydrophobic DRUGS [Internet]. Pharmacie Globale (IJCP). 2011. Available from: www.pharmacie-globale.info
43. Solubility Enhancement Techniques of Anti-Microbial Agents of BCS Class II and IV Drugs. 2022
44. Aishwarya M, Karande A, Amol M, Deshmukh S. Ms. Aishwarya Audumbar Karande et al, Review on Inclusion Complexation: A Technique to Enhance the Solubility of Poorly Water Soluble Drug Review on Inclusion Complexation: A Technique to Enhance the Solubility of Poorly Water Soluble Drug [Internet]. Vol. 2, IJRPAS. Available from: https://idealpublication.in/ijrpas/
45. Hussein M, An /, Ahmed IK. An Overview of Technique for Solubility of Poorly Water Soluble Drugs. 2022; 20: 8027–38. Available from: www.neuroquantology.com
46. Tran P, Pyo YC, Kim DH, Lee SE, Kim JK, Park JS. Overview of the manufacturing methods of solid dispersion technology for improving the solubility of poorly water-soluble drugs and application to anticancer drugs. Pharmaceutics. MDPI AG; 2019; 11.
47. R GN, M SM, R VS, M GN. Review: Solubility Enhancement by Advance Techniques-Lyophilization, Spray Drying And Rotary Evaporator Method. Gade et al World Journal of Pharmaceutical Research [Internet]. 2020; 9: 1127. Available from: www.wjpr.net
48. Vimalson DC, Parimalakrishnan S, Jeganathan NS, Anbazhagan S. Techniques to Enhance Solubility of Hydrophobic Drugs: An Overview. Asian Journal of Pharmaceutics.
49. Jadhav SP, Singh SK, Chawra HS. Review on Nanosuspension as a Novel Method for Solubility and Bioavailability Enhancement of Poorly Soluble Drugs. Advances in Pharmacology and Pharmacy. 2023; 11(2): 117–30.
50. Pawar SR, Barhate SD. Solubility enhancement (Solid Dispersions) novel boon to increase bioavailability. Journal of Drug Delivery and Therapeutics. 2019; 9(2): 583–90.
51. Jagtap S, Magdum C, Jadge D, Jagtap R. Solubility Enhancement Technique: A Review. Journal of Pharmaceutical Sciences and Research. 2018; 10(9): 2205-2211.
52. Devhare LD, Kore PK. A Recent Review on Bioavailability and Solubility Enhancement of Poorly Soluble Drugs by Physical and Chemical Modifications [Internet]. Available from: https://ssrn.com/abstract=4455504
53. Kumar P, Singh C. A Study on Solubility Enhancement Methods for Poorly Water Soluble Drugs. Am J Pharmacol Sci. 2013; 1(4): 67–73.
54. Gupta S, Sawarkar S, Ravikumar P. Solubility Enhancement Of Poorly Water Soluble Protease Inhibitor. Int J Pharm Sci Res [Internet]. 2016; 7(1): 252–8. Available from: http://dx.doi.org/10.13040/IJPSR.0975-8232.7
55. Budiman A, Rusdin A, Aulifa DL. Current Techniques of Water Solubility Improvement for Antioxidant Compounds and Their Correlation with Its Activity: Molecular Pharmaceutics. Antioxidants. MDPI; 2023; 12.
56. Kesarwani P, Rastogi S, Bhalla V, Arora V. Solubility Enhancement Of Poorly Water Soluble Drugs: A Review. Int J Pharm Sci Res [Internet]. 2014; 5(8): 3123. Available from: http://dx.doi.org/10.13040/IJPSR.0975-8232.5
57. Kesharwani SS, Jain V, Dey S, Sharma S, Mallya P, Kumar VA. An overview of advanced formulation and nanotechnology-based approaches for solubility and bioavailability enhancement of silymarin. Vol. 60, Journal of Drug Delivery Science and Technology. Editions de Sante. 2020.