Author(s):
Candra Irawan, Berna Elya, Muhammad Hanafi, Abdul Mun’im
Email(s):
berna.elya@farmasi.ui.ac.id
DOI:
10.52711/0974-360X.2025.00486 
Address:
Candra Irawan1,2, Berna Elya1*, Muhammad Hanafi3,4, Abdul Mun’im1
1Faculty of Pharmacy Universitas Indonesia, Depok, West Java 16424, Indonesia.
2Department of Food Nanotechnology, Politeknik AKA Bogor, Bogor, West Java 16154, Indonesia.
3Research Center for Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovatioan Agency-BRIN, Kawasan Puspiptek, Tangerang Selatan 15134 Indonesia.
4Faculty of Pharmacy Universitas Pancasila, Jakarta Selatan 12640, Indonesia.
*Corresponding Author
Published In:
Volume - 18,
Issue - 7,
Year - 2025
ABSTRACT:
Background: There are only 10 species that have been identified from the genus Rhinacantus, but only Rhinacanthus nasutus (L.) Kurz (RK) has been found in published studies. This shrub's roots, stems, and leaves have been used in traditional medicine to treat dermatitis, pulmonary tuberculosis, herpes, hepatitis, diabetes, hypertension, obesity, leprosy, scurvy, and a number of skin diseases. Aim: This study summarizes research on the chemical compounds contained in the RK plant and their bioactivity. Method: A total of 80 articles including original research papers, books, downloaded book chapters and 50 articles (most of them relevant to the topic) were selected to write the study articles. The articles are rejected because they are irrelevant. Results: Naphthoquinone analogues are the main bioactive compounds contained in the RK. Apart from that, there are also anthraquinone compounds, lignin, flavonoids, steroids, and terpenoids. Various extracts and compounds have been found to have biological activity. Naphthoquinone: known as rhinacanthin-C and -D, extracted from RK has been reported to have potent anti-inflammatory, antidiabetic activity with a-glycosidase inhibitors, and antivirus. RK showed several other characteristic pharmacological effects such as inhibitor of platelet aggregation, antibacterial, allergy, antifungal, anticancer, and so on. Discussion: In the future, exploration of the Rhinacanthus sp. plant needs to be done because there are still many parts of this plan that have not been studied for its application as modern medicine.
Cite this article:
Candra Irawan, Berna Elya, Muhammad Hanafi, Abdul Mun’im. Study on Chemical Compounds and Plant Bioactivity of Rhinacanthus sp - Review Article. Research Journal of Pharmacy and Technology. 2025;18(7):3358-5. doi: 10.52711/0974-360X.2025.00486
Cite(Electronic):
Candra Irawan, Berna Elya, Muhammad Hanafi, Abdul Mun’im. Study on Chemical Compounds and Plant Bioactivity of Rhinacanthus sp - Review Article. Research Journal of Pharmacy and Technology. 2025;18(7):3358-5. doi: 10.52711/0974-360X.2025.00486 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-7-66
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