ABSTRACT:
In recent years, the transdermal route has emerged as the preferred method for medication delivery. The transdermal drug delivery system addresses several drawbacks associated with the oral route, particularly first-pass metabolism. However, the efficacy of transdermal delivery is limited, as only a select few drug particles can effectively penetrate the stratum corneum. To address this difficulty, our scientists and researchers have created a novel system called the ultra-deformable vesicle system (UDV). This technique incorporates medication molecules, whether synthetic or herbal, into vesicles that facilitate deeper skin penetration for targeted drug delivery. Between Transferosomes and Ethosomes Transethosomes represent a promising advancement for improved transdermal medication administration via the skin. The successful permeation of nanotransethosomes is attributed to ethanol, edge activators, and phospholipids. Various methods exist for the creation of nanotransethosomes, including the hot method, cold method, transmembrane pH gradient method, ethanol injection method, and thin film hydration method. The UDV can be employed for the transdermal administration of various medication classes, including anti-arthritic, antibacterial, anticancer, antiviral, and analgesic agents.