Author(s):
Mahdi Jufri, Saintica Luthfia Utama, Asri Kartika Ratri, Bunga Atqiya Qutrunnada, Roshamur Cahyan Forestrania, Tommy Julianto Bustami, Adilah Marwa
Email(s):
mahdi.jufri@farmasi.ui.ac.id
DOI:
10.52711/0974-360X.2025.00473 
Address:
Mahdi Jufri1*, Saintica Luthfia Utama1, Asri Kartika Ratri1, Bunga Atqiya Qutrunnada1, Roshamur Cahyan Forestrania1, Tommy Julianto Bustami2, Adilah Marwa1,3,4
1Laboratory of Pharmaceutics and Pharmaceutical Technology Development, Faculty of Pharmacy, Universitas Indonesia, Depok 16424, West Java, Indonesia.
2Laboratory of Pharmacetical Technology, Faculty of Pharmacy University Technology, Mara, Malaysia.
3Departement of Pharmacy, Institute of Tarumanagara, South Jakarta, 12550, Indonesia.
4Research Center for Chemistry, National Research and Innovation Agency (BRIN), Serpong, 15314, Indonesia.
*Corresponding Author
Published In:
Volume - 18,
Issue - 7,
Year - 2025
ABSTRACT:
The oil extracted from Moringa seeds (Moringa oleifera Lam.) Moringa seeds oil (MSO) is known to have antioxidant activity potential. This study aims to obtain the optimum formulation of topical nanoemulsion preparations from Moringa seed oil, including its evaluation in stability and activity antioxidant. Moringa seed oil was characterized and then formulated into cream and serum preparations. The physical stability test of the two preparations to evaluate their shelf life was conducted in 12 weeks of storage at room temperature, and their antioxidant activity was tested using the DPPH method. The oil has a total fatty acid content of 65% w/w with a dominant oleic acid content and the IC50 value of 147.0277 µg/mL. The Moringa seeds oil was prepared as nanoemulsion for cream and serum. The optimum formula of nanoemulsion has an average droplet size of 212 nm, a polydispersity index (PDI) of 0.355, a zeta potential of -40.6 mV, and an entrapment efficiency of 58.59%. The stability studies found the two topical preparations stable during storage, with a slightly increased in viscosity and droplet size. The antioxidant activity of cream and serum were decreased after storage for 12 weeks.
Cite this article:
Mahdi Jufri, Saintica Luthfia Utama, Asri Kartika Ratri, Bunga Atqiya Qutrunnada, Roshamur Cahyan Forestrania, Tommy Julianto Bustami, Adilah Marwa. Antioxidant Activity of Moringa Seed Oil (Moringa oleifera Lam.) Nanoemulsion Cosmetics Cream and Serum. Research Journal of Pharmacy and Technology. 2025;18(7):3278-5. doi: 10.52711/0974-360X.2025.00473
Cite(Electronic):
Mahdi Jufri, Saintica Luthfia Utama, Asri Kartika Ratri, Bunga Atqiya Qutrunnada, Roshamur Cahyan Forestrania, Tommy Julianto Bustami, Adilah Marwa. Antioxidant Activity of Moringa Seed Oil (Moringa oleifera Lam.) Nanoemulsion Cosmetics Cream and Serum. Research Journal of Pharmacy and Technology. 2025;18(7):3278-5. doi: 10.52711/0974-360X.2025.00473 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-7-53
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