ABSTRACT:
The mucilage from Plantago ovata is being explored as a novel, highly effective disintegrating component in the creation of rapidly dissolving tablets for drugs that are not easily soluble, due to its enhanced compatibility with living systems and its attraction to water. This research aims to evaluate the immediate and delayed toxicity levels of Plantago ovata mucilage in Wistar rats. In the initial phase, the mucilage was given to Wistar rats in a single dose over a period of seven days. For the subsequent phase, both sexual Wistar rats have being subjected to a twenty-eight days study to evaluate the effects of oral dosages ranging from 50 to 600 milligrams per kilogram of body weight daily on various parameters including body mass, aliment consumption, death rates, biochemical tests, and histological examinations. The initial study showed that the highest dose of Plantago ovata mucilage that did not cause death in rats was above 2000 milligrams per kilogram of body mass. The follow-up study on subacute toxicity did not reveal any significant differences in contrast to the group under supervision, and there were no alterations in blood or biochemical levels. The pancreatic, kidneys, and liver weights were also consistent. From these results, it was determined that Plantago ovata mucilage at a dosage of 2000 mg/kg body mass daily was not chimeric or weakening, and did not affect reproduction or development, suggesting it is generally safe for oral consumption.