Author(s):
Isdoni, Amaq Fadholly, Siti Sa'diah, Aulia A. Mustika, Trifena Angelina, Alifia M. Nanginda
Email(s):
amaqfadholly@apps.ipb.ac.id
DOI:
10.52711/0974-360X.2025.00425 
Address:
Isdoni1, Amaq Fadholly2,4*, Siti Sa'diah2,5, Aulia A. Mustika2, Trifena Angelina3, Alifia M. Nanginda3
1Division of Physiology, School of Veterinary Medicine and Biomedical Sciences, IPB University, Indonesia.
2Division of Pharmacology and Toxicology, School of Veterinary Medicine and Biomedical Sciences, IPB University, Indonesia.
3Bachelor Program in Veterinary Medicine, School of Veterinary Medicine and Biomedical Sciences, IPB University, Indonesia.
4Laboratory Animal Management Unit, School of Veterinary Medicine and Biomedical Sciences, IPB University, Indonesia.
5Tropical Biopharmaca Research Center, School of Veterinary Medicine and Biomedical Sciences, IPB University, Indonesia.
*Corresponding Author
Published In:
Volume - 18,
Issue - 7,
Year - 2025
ABSTRACT:
Cassia alata is widely used as a medicinal plant including constipation, mostly in Asia. This study was conducted to evaluate the laxative effect of Cassia alata leaves extract. The laxative activity was performed in three doses (50, 100, 200mg/kg BW) and included three control groups (normal, negative and positive control which used bisacodyl) in rats. Fecal parameters and gastrointestinal transit ratio methods are prepared for laxative analysis. This study reported that all doses of treatment increase the number of fecal and repair the consistency of the fecal output, while the gastrointestinal transit showed that the treatment made the stained intestinal tract shorter.In conclusion that Cassia alata leaves extract was found to produce significant in fecal output and resulting in a short gastrointestinal transit ratio showing laxative activity, and the dose 50mg/kgBB being more potent. It is a potential compound to be developed as a laxative agent for constipation treatment.
Cite this article:
Isdoni, Amaq Fadholly, Siti Sa'diah, Aulia A. Mustika, Trifena Angelina, Alifia M. Nanginda. Laxative Potential of Cassia alata Leaves Extract: In Vivo Study. Research Journal of Pharmacy and Technology. 2025;18(7): 2967-0. doi: 10.52711/0974-360X.2025.00425
Cite(Electronic):
Isdoni, Amaq Fadholly, Siti Sa'diah, Aulia A. Mustika, Trifena Angelina, Alifia M. Nanginda. Laxative Potential of Cassia alata Leaves Extract: In Vivo Study. Research Journal of Pharmacy and Technology. 2025;18(7): 2967-0. doi: 10.52711/0974-360X.2025.00425 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-7-5
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