Author(s):
Sakshi H. Puttawar, Avinash S. Bhosale, Gayatri B. Patil, Omkar B. Bade, Suraj K. Kalebag
Email(s):
sakshiputtawar222@gmail.com
DOI:
10.52711/0974-360X.2025.00441 
Address:
Sakshi H. Puttawar*, Avinash S. Bhosale, Gayatri B. Patil, Omkar B. Bade, Suraj K. Kalebag
Department of Pharmaceutical Quality Assurance, Satara College of Pharmacy, Satara, Dr. Babasaheb Ambedkar Technological University, Lonere, 415004, Maharashtra, India.
*Corresponding Author
Published In:
Volume - 18,
Issue - 7,
Year - 2025
ABSTRACT:
Aim: The objective of the present investigation was to design arjuna bark suppositories for the effective treatment of asherman’s syndrome to eliminate side effects that are caused by existing synthetic drugs. Materials and Methods: Arjuna Bark has promising anti-inflammatory activity in comparison with the existing nonsteroidal anti-inflammatory drugs. Arjuna Bark suppositories were prepared by fusion method with the combination of polyethylene glycol 6000 and polyethylene glycol 4000 in different ratios. The suppositories were evaluated for their visual, physicochemical, weight variation, meting point and melting range, hardness, disintegration, drug content, and in-vitro drug release characteristics. Result and Discussion: Results of all the parameters were said to be in standard limits. Formulation F5 showed all the results within the pharmacopeial and in-house specification. Conclusion: The study indicates the possible and effective use of arjuna bark suppositories for asherman’s syndrome as a promising approach for natural anti-inflammatory treatment.
Cite this article:
Sakshi H. Puttawar, Avinash S. Bhosale, Gayatri B. Patil, Omkar B. Bade, Suraj K. Kalebag. Arjuna Bark-Infused Herbal Suppositories: A Novel Approach for Treating Asherman Syndrome. Research Journal of Pharmacy and Technology. 2025;18(7):3080-4. doi: 10.52711/0974-360X.2025.00441
Cite(Electronic):
Sakshi H. Puttawar, Avinash S. Bhosale, Gayatri B. Patil, Omkar B. Bade, Suraj K. Kalebag. Arjuna Bark-Infused Herbal Suppositories: A Novel Approach for Treating Asherman Syndrome. Research Journal of Pharmacy and Technology. 2025;18(7):3080-4. doi: 10.52711/0974-360X.2025.00441 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-7-21
REFERENCES:
1. Yadav S, Kaushik S, Chhikara SK, Singh S, Yadav JP, Kaushik S. Terminalia arjuna (Arjun Tree): A Sacred plant with high medicinal and therapeutic potential. Research Journal of Pharmacy and Technology. 2022; 15(12): 5859-67. doi: http://dx.doi.org/10.52711/0974-360X.2022.00989
2. Jain S, Yadav PP, Gill V, Vasudeva N, Singla N. Terminalia arjuna a sacred medicinal plant: phytochemical and pharmacological profile. Phytochemistry Reviews. 2009 Jun; 8: 491-502. doi: https://doi.org/10.1007/s11101-009-9134-8
3. Sai RA, Godwin CJ, Thankamani V. Comparative Study on Antioxidant Property of Terminalia arjuna Bark and Corewood. Research Journal of Pharmacy and Technology. 2013; 6(9): 996-1000.
4. Thakur S, Kaurav H, Chaudhary G. Terminalia arjuna: a potential ayurvedic cardio tonic. International Journal for Research in Applied Sciences and Biotechnology. 2021; Mar 31; 8(2): 227-36.doi: https://doi.org/10.31033/ijrasb.8.2.30
5. Cock IE. The medicinal properties and phytochemistry of plants of the genus Terminalia (Combretaceae). Inflammopharmacology. 2015; Oct; 2: 203-29. doi: https://doi.org/10.1007/s10787-015-0246-z
6. Abbaspour M, Hoseini H, Sobhani Z, Emami SA, Bazzaz BS, Javadi B. Development and evaluation of vaginal suppository containing Althaea officinalis L. polysaccharide extract. Brazilian Journal of Pharmaceutical Sciences. 2022; 58: e20868. doi: http://dx.doi.org/10.1590/s2175-97902022e20868
7. Havaldar VD, Yadav AV, Dias RJ, Mali KK, Ghorpade VS, Salunkhe NH. Rectal suppository as an effective alternative for oral administration. Research Journal of Pharmacy and Technology. 2015; 8(6):759-66. doi:http://dx.doi.org/10.5958/0974-360X.2015.00122.5
8. Osmani RA, Kulkarni PK, Shanmuganathan S, Hani U, Srivastava A, Prerana M, Shinde CG, Bhosale RR. A 3 2 full factorial design for development and characterization of a nanosponge-based intravaginal in situ gelling system for vulvovaginal candidiasis. RSC Advances. 2016; 6(23): 18737-50. doi: https://doi.org/10.1039/C5RA26218F
9. Norman JE, Marlow N, Messow CM, Shennan A, Bennett PR, Thornton S, Robson SC, McConnachie A, Petrou S, Sebire NJ, Lavender T. Vaginal progesterone prophylaxis for preterm birth (the OPPTIMUM study): a multicentre, randomised, double-blind trial. The Lancet. 2016; May 21; 387(10033): 2106-16. doi: http://dx.doi.org/10.1016/S0140-6736(16)00350-0.
10. Daga AS, Ingole BD, Kulkarni SS, Biyani KR. Self emulsifying drug delivery system: Hitherto and Novel approach. Research Journal of Pharmacy and Technology. 2012; 5(6): 736-45.
11. Samanta A, Roy A, Majumdar M. Study of various formulations for enhancement of systemic bioavailability of curcumin. Research Journal of Pharmacy and Technology. 2018; 11(2): 661-6. doi: http://dx.doi.org/10.5958/0974-360X.2018.00124.5
12. Firoz S, Rajasekaran S. A survey on mucoadhesive thermoreversible drug delivery system with special emphasis on recto-anal region for the treatment of internal hemorrhoids. Research Journal of Pharmacy and Technology. 2021; 14(5): 2878-86. doi: http://dx.doi.org/10.52711/0974-360X.2021.00506
13. Patil CC, Pawar VV, Karajgi SR, Kalyane NV. Formulation and Evaluation of Mucoadhesive Buccal Tablets of Ondansetron Hydrochloride. Research Journal of Pharmacy and Technology. 2018; 11(2): 581-6. doi: http://dx.doi.org/10.5958/0974-360X.2018.00107.5
14. Havaldar VD, Yadav AV, Dias RJ, Mali KK, Ghorpade VS, Salunkhe NH. Rectal suppository as an effective alternative for oral administration. Research Journal of Pharmacy and Technology. 2015; 8(6): 759-66. doi: http://dx.doi.org/10.5958/0974-360X.2015.00122.5
15. Dakhil IA, Mohamed MB, Abbas AK, Mansour SM. Formulation and Evaluation of Trifluoperazine HCl as rectal suppositories by using different types of surfactants in Cocoa butter. Research Journal of Pharmacy and Technology. 2019; 12(10): 4934-40. doi: http://dx.doi.org/10.5958/0974-360X.2019.00856.4
16. Chushenko VM, Yarnykh TG, Yuryeva GB, Herasymova IV. Creation of Cocoa butter bases for preparation of suppositories in pharmacy condition by the casting method. Research Journal of Pharmacy and Technology. 2020; 13(7): 3343-6. doi: http://dx.doi.org/10.5958/0974-360X.2020.00593.4
17. Dewangan K, Nagori K, Sharma M, Singh A, Chandrakar S, Sahu VD, Sharma G, Gupta S, Solanki H, Majumdar M, Tripathi DK. Formulation, evaluation and release studies of Indomethacin Suppositories. Research Journal of Pharmacy and Technology. 2016; 9(7): 942-4. doi: http://dx.doi.org/10.5958/0974-360X.2016.00181.5
18. Sudke SG. Design of curcumin suppositories for effective treatment of vaginal candidiasis using cow ghee as a suppository base. Asian Journal of Pharmaceutics (AJP). 2017; 11(04). doi: https://doi.org/10.22377/ajp.v11i04.1765