Author(s):
Denny Satria, Nazliniwaty, Olivia Avriyanti Hanafiah, Dewi Pertiwi, Syukur Berkat Waruwu, Vera Estefania Kaban
Email(s):
dennysatria@usu.ac.id
DOI:
10.52711/0974-360X.2025.00440 
Address:
Denny Satria1*, Nazliniwaty2, Olivia Avriyanti Hanafiah3, Dewi Pertiwi1, Syukur Berkat Waruwu4, Vera Estefania Kaban5
1Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan 20155, Indonesia.
2Department of Pharmaceutical Technology, Faculty of Pharmacy, Universitas Sumatera Utara, Medan 20155, Indonesia.
3Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Universitas Sumatera Utara, Medan 20155, Indonesia.
4Faculty of Pharmacy and Health Sciences, Universitas Sari Mutiara Indonesia, Medan 20123, Indonesia.
5Department of Clinical Pharmacy, Faculty of Medicine, Dentistry and Health Sciences, Universitas Prima Indonesia, Medan 20118 Indonesia.
*Corresponding Author
Published In:
Volume - 18,
Issue - 7,
Year - 2025
ABSTRACT:
Antioxidants are compounds that have the ability to impede the function of free radicals. The uncontrolled production of free radicals can cause several types of diseases that can result in death, such as diabetes, heart disease, and cancer. Antioxidants are produced internally (endogenous) or obtained outside the body, for example through food consumption (exogenous). Mobe leaves (Artocarpus lakoocha Buch. Ham) contain high levels of flavonoids and phenols, which can potentially be effective against free radicals. This research was conducted to determine the artocarpin content in the ethanol extract of Mobe leaves and test its antioxidant activity using various methods. Predictions of bioactivity, toxicity, and bio-pharmacokinetic profiles (absorption, distribution, metabolism, excretion, toxicity) of artocarpin compounds from this plant were also examined. The data on artocarpin levels in Mobe extract were 37.67±0.85mg/g. The limit of detection value is 0.34 µg/mL, and the limit of quantification value is 1.18µg/mL. The IC50 values of the extracts were 144.26±0.02 (FRAP), 83.39 ± 0.07 (CUPRAC), 161.26±0.09 (Hydroxyl), and 191.46±0.13µg/mL (O-Phenanthroline). The predicted results of bioactivity, toxicity, and bio pharmacokinetic profiles also show great potential to be developed into natural medicines.
Cite this article:
Denny Satria, Nazliniwaty, Olivia Avriyanti Hanafiah, Dewi Pertiwi, Syukur Berkat Waruwu, Vera Estefania Kaban. ADMET properties, antioxidant activity and determination of Artocarpin level in hydroalcohol extract of Artocarpus lakoocha Buch. Ham leaves. Research Journal of Pharmacy and Technology. 2025;18(7):3073-9. doi: 10.52711/0974-360X.2025.00440
Cite(Electronic):
Denny Satria, Nazliniwaty, Olivia Avriyanti Hanafiah, Dewi Pertiwi, Syukur Berkat Waruwu, Vera Estefania Kaban. ADMET properties, antioxidant activity and determination of Artocarpin level in hydroalcohol extract of Artocarpus lakoocha Buch. Ham leaves. Research Journal of Pharmacy and Technology. 2025;18(7):3073-9. doi: 10.52711/0974-360X.2025.00440 Available on: https://rjptonline.org/AbstractView.aspx?PID=2025-18-7-20
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